2.5.1.101: N,N'-diacetyllegionaminate synthase
This is an abbreviated version!
For detailed information about N,N'-diacetyllegionaminate synthase, go to the full flat file.
Word Map on EC 2.5.1.101
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2.5.1.101
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ubiquitin-conjugating
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polyubiquitination
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ligases
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ubiquitin-mediated
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scfcdc4
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multiubiquitination
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ck2-mediated
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scf-mediated
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autoubiquitination
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ub-conjugating
- 2.5.1.101
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ubiquitin-conjugating
-
polyubiquitination
-
ligases
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ubiquitin-mediated
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scfcdc4
-
multiubiquitination
-
ck2-mediated
-
scf-mediated
-
autoubiquitination
-
ub-conjugating
Reaction
Synonyms
legI, N,N'-diacetyllegionaminic acid synthase, NeuB, NeuB homologue, nonulosonic acid synthase
ECTree
2.5.1.101 N,N'-diacetyllegionaminate synthaseAdvanced search results
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General Information on EC 2.5.1.101 - N,N'-diacetyllegionaminate synthase
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GENERAL INFORMATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
evolution
metabolism
additional information
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NeuB can be substituted by NanA from Escherichia coli, a sialic acid aldolase that catalyzes the condensation of 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose with pyruvate resulting in N,N'-diacetyllegionaminate formation, ability of sialyltransferases to utilize the CMP-N,N'-diacetyllegionaminate donor, overview
evolution
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the gene encoding the enzyme shows homology to known sialic acid biosynthetic gene neuB
evolution
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the gene encoding the enzyme shows homology to known sialic acid biosynthetic gene neuB
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metabolism
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the enzyme is involved in the the Leg pathway, which is essential for the biosynthesis of CMP-N,N'-diacetyllegionaminate, that acts as a donor substrate with a selection of bacterial and mammalian sialyltransferases
metabolism
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the enzyme is part of the biosynthesis of legionaminic acid and its CMP-activated form, metabolite determination and identification by NMR spectroscoopy for pathway construction and analysis, overview
metabolism
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the three enzymes, UDP-N,N'-diacetylbacillosamine 2-epimerase, N,N'-diacetyllegionaminic acid synthase, and CMP-N,N'-diacetyllegionaminic acid synthetase, constitute a pathway that converts a UDP-linked bacillosamine derivative into a CMP-linked legionaminic acid derivative, the activated form of legionaminic acid used in lipopolysaccharide biosynthesis, overview
metabolism
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the three enzymes, UDP-N,N'-diacetylbacillosamine 2-epimerase, N,N'-diacetyllegionaminic acid synthase, and CMP-N,N'-diacetyllegionaminic acid synthetase, constitute a pathway that converts a UDP-linked bacillosamine derivative into a CMP-linked legionaminic acid derivative, the activated form of legionaminic acid used in lipopolysaccharide biosynthesis, overview
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metabolism
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the enzyme is part of the biosynthesis of legionaminic acid and its CMP-activated form, metabolite determination and identification by NMR spectroscoopy for pathway construction and analysis, overview
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