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2.5.1.10: (2E,6E)-farnesyl diphosphate synthase

This is an abbreviated version!
For detailed information about (2E,6E)-farnesyl diphosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.10

Reaction

geranyl diphosphate
+
isopentenyl diphosphate
=
diphosphate
 +
(2E,6E)-farnesyl diphosphate

Synonyms

At4g36810, bifunctional farnesyl/geranylgeranyl diphosphate synthase, E-farnesyl diphosphate synthase, E-FPP synthase, ERG20, farnesyl diphosphate synthase, farnesyl diphosphate synthase 1, farnesyl diphosphate synthase 2, farnesyl pyrophosphate synthase, farnesyl pyrophosphate synthetase, farnesyl-diphosphate synthase, farnesylpyrophosphate synthetase, FDPSase, FDS, FPP synthase, FPP-synthase, FPPase, FPPS, FPPS/GGPPS, FPPS1, FPPS2, FPPS3, FPS, Fps1, FPS2, geranyl transferase I, geranyltranstransferase, GGPPS11, hFPPS, HpGGPPS, IspA, LS1, MpFPPS1, MpFPPS2, omega,E,E-farnesyl diphosphate synthase, omega,E,E-FPP, PA4043, PcIDS1, prenyltransferase, type I farnesyl diphosphate synthase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.10 (2E,6E)-farnesyl diphosphate synthase

Molecular Weight

Molecular Weight on EC 2.5.1.10 - (2E,6E)-farnesyl diphosphate synthase

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100000
x * 100000, SDS-PAGE
103000
-
SDS-PAGE after cross-linking with dimethyl suberimidate
110000
-
gel filtration
39000
-
x * 39000, SDS-PAGE
39400
x * 39400, calculated from amino acid sequence
39800
calculated from sequence
39900
x * 39900, calculated from amino acid sequence
40700
-
-
40730
calculated from sequence
40800
-
-
45500
2 * 45500, isoform FPPS1, calculated from amino acid sequence
45800
-
2 * 45800, the enzyme is always present as a dimer regardless of the added cofactor, in the case of Mg2+, the dimeric protein possesses the largest volume (93800 Da), most likely due to a more relaxed conformation. With Co2+, the enzyme seems to have a more compact conformation (87600 Da), which may be responsible for the change in product spectrum calculated from sequence
45900
2 * 45900, isoform FPPS2, calculated from amino acid sequence
47000
-
2 * 50000, calculated, 2 * 47000, SDS-PAGE
50000
-
2 * 50000, calculated, 2 * 47000, SDS-PAGE
56000
58000
60000
-
gel filtration, enzyme II, protein concentration 0.02 mg/ml
67000
-
gel filtration
69600
x * 69600, calculated from amino acid sequence
72500
-
gel filtration, protein concentration 25 mg/ml
74000
-
gel filtration
75000
x * 75000, recombinant enzyme, SDS-PAGE
87600
-
enzyme-Co2+ complex, gel filtration
93800
-
enzyme-Mg2+ complex, gel filtration