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2.5.1.10: (2E,6E)-farnesyl diphosphate synthase

This is an abbreviated version!
For detailed information about (2E,6E)-farnesyl diphosphate synthase, go to the full flat file.

Word Map on EC 2.5.1.10

Reaction

geranyl diphosphate
+
isopentenyl diphosphate
=
diphosphate
 +
(2E,6E)-farnesyl diphosphate

Synonyms

At4g36810, bifunctional farnesyl/geranylgeranyl diphosphate synthase, E-farnesyl diphosphate synthase, E-FPP synthase, ERG20, farnesyl diphosphate synthase, farnesyl diphosphate synthase 1, farnesyl diphosphate synthase 2, farnesyl pyrophosphate synthase, farnesyl pyrophosphate synthetase, farnesyl-diphosphate synthase, farnesylpyrophosphate synthetase, FDPSase, FDS, FPP synthase, FPP-synthase, FPPase, FPPS, FPPS/GGPPS, FPPS1, FPPS2, FPPS3, FPS, Fps1, FPS2, geranyl transferase I, geranyltranstransferase, GGPPS11, hFPPS, HpGGPPS, IspA, LS1, MpFPPS1, MpFPPS2, omega,E,E-farnesyl diphosphate synthase, omega,E,E-FPP, PA4043, PcIDS1, prenyltransferase, type I farnesyl diphosphate synthase

ECTree

     2 Transferases
         2.5 Transferring alkyl or aryl groups, other than methyl groups
             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
                2.5.1.10 (2E,6E)-farnesyl diphosphate synthase

KI Value

KI Value on EC 2.5.1.10 - (2E,6E)-farnesyl diphosphate synthase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00054
(R)-(1-((6-(3-chloro-4-methylphenyl)thieno[2,3-d]-pyrimidin-4-yl)amino)-2-(3-fluorophenyl)ethyl)phosphonic acid
pH 7.7, 37°C
0.003
(R)-(1-((6-(3-chloro-4-methylphenyl)thieno[2,3-d]-pyrimidin-4-yl)amino)-2-cyclohexylethyl)phosphonic acid
pH 7.7, 37°C
0.0015
(R)-(1-((6-(3-chloro-4-methylphenyl)thieno[2,3-d]-pyrimidin-4-yl)amino)-2-phenylethyl)phosphonic acid
pH 7.7, 37°C
0.0028
(R)-(2-(3-fluorophenyl)-1-((6-(p-tolyl)thieno[2,3-d]-pyrimidin-4-yl)amino)ethyl)phosphonic acid
pH 7.7, 37°C
0.0077
(R)-(2-phenyl-1-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)-amino)ethyl)phosphonic acid
pH 7.7, 37°C
0.001
(R)-2-((6-(3-chloro-4-methylphenyl)thieno[2,3-d]-pyrimidin-4-yl)amino)-3-(3-fluorophenyl)propanoic acid
pH 7.7, 37°C
0.0011
(S)-(1-((6-(3-chloro-4-methylphenyl)thieno[2,3-d]-pyrimidin-4-yl)amino)-2-(3-fluorophenyl)ethyl)phosphonic acid
pH 7.7, 37°C
0.0081
(S)-(1-((6-(3-chloro-4-methylphenyl)thieno[2,3-d]-pyrimidin-4-yl)amino)-2-cyclohexylethyl)phosphonic acid
pH 7.7, 37°C
0.0037
(S)-(1-((6-(3-chloro-4-methylphenyl)thieno[2,3-d]-pyrimidin-4-yl)amino)-2-phenylethyl)phosphonic acid
pH 7.7, 37°C
0.0012
(S)-(2-(3-fluorophenyl)-1-((6-(p-tolyl)thieno[2,3-d]-pyrimidin-4-yl)amino)ethyl)phosphonic acid
pH 7.7, 37°C
0.0028
(S)-(2-phenyl-1-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)-amino)ethyl)phosphonic acid
pH 7.7, 37°C
0.000001
1-(2-hydroxy-2,2-diphosphonoethyl)-3-phenylpyridinium
-
pH and temperature not specified in the publication
0.00005
3-fluoro-1-(2-hydroxy-2,2-diphosphonoethyl)-pyridinium
-
pH and temperature not specified in the publication
0.00026
alendronate
pH and temperature not specified in the publication
0.00298
APHBP
pH and temperature not specified in the publication
0.322
geranyl diphosphate
-
fixed substrate isopentenyl diphosphate (0.05 mM), pH and temperature not specified in the publication, metal cofactor: Mg2+
0.0007 - 1.05
isopentenyl diphosphate
0.000388
neridronate
pH and temperature not specified in the publication
0.000352
pamidronate
pH and temperature not specified in the publication
0.000011
zoledronate
-
pH and temperature not specified in the publication