2.5.1.10: (2E,6E)-farnesyl diphosphate synthase

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For detailed information about (2E,6E)-farnesyl diphosphate synthase, go to the full flat file.

Reaction

Synonyms

At4g36810, bifunctional farnesyl/geranylgeranyl diphosphate synthase, E-farnesyl diphosphate synthase, E-FPP synthase, ERG20, farnesyl diphosphate synthase, farnesyl diphosphate synthase 1, farnesyl diphosphate synthase 2, farnesyl pyrophosphate synthase, farnesyl pyrophosphate synthetase, farnesyl-diphosphate synthase, farnesylpyrophosphate synthetase, FDPSase, FDS, FPP synthase, FPP-synthase, FPPase, FPPS, FPPS/GGPPS, FPPS1, FPPS2, FPPS3, FPS, Fps1, FPS2, geranyl transferase I, geranyltranstransferase, GGPPS11, hFPPS, HpGGPPS, IspA, LS1, MpFPPS1, MpFPPS2, omega,E,E-farnesyl diphosphate synthase, omega,E,E-FPP, PA4043, PcIDS1, prenyltransferase, type I farnesyl diphosphate synthase

ECTree

     2 Transferases

         2.5 Transferring alkyl or aryl groups, other than methyl groups

             2.5.1 Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

                2.5.1.10 (2E,6E)-farnesyl diphosphate synthase

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Results	in table
10	Activating Compound
7438	AA Sequence
5	Application
1	CAS Registry Number
28	Cloned(Commentary)
16	Crystallization (Commentary)
366	Disease/ Diagnostics
6	Expression
54	General Information
1	General Stability
142	IC50 Value
275	Inhibitors
21	Ki Value [mM]
47	KM Value [mM]
6	Localization
31	Metals/Ions
32	Molecular Weight [Da]
60	Natural Substrates/ Products (Substrates)
295	Organism
1	Oxidation Stability
10	Pathway
255	PDB ID
9	pH Optimum
3	pH Range
1	pH Stability
9	pI Value
66	Protein Variants
27	Purification (Commentary)
2	Reaction
1	Reaction Type
103	Reference
32	Source Tissue
14	Specific Activity [micromol/min/mg]
4	Storage Stability
145	Substrates and Products (Substrate)
32	Subunits
147	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
6	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 2.5.1.10 - (2E,6E)-farnesyl diphosphate synthase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1,4-dithiothreitol

Bacillus subtilis

-

2 mM, 1.6fold stimulation

638683

2-mercaptoethanol

Bacillus subtilis

-

10 mM, 1.2fold stimulation

638683

dithioerythritol

Homo sapiens

-

-

638695

dithiothreitol

Mycobacterium tuberculosis

-

2.5 mM, increases activity 2fold

659667

NH4+

2 entries

Triton X-100

2 entries

Tween 80

Bacillus subtilis

-

0.5%, 2.3fold activation

638683

additional information

Abies grandis

-

not activated by Tween 20, Triton X-100, Chaps or Nonidet P-40

638706

-

NH4+

Bacillus subtilis

-

3fold stimulation with geranyl diphosphate as substrate

638683

NH4+

Bacillus subtilis

-

5fold stimulation with dimethylallyl diphosphate as substrate

638683

Triton X-100

Bacillus subtilis

-

0.5%, 3fold activation

638683

Triton X-100

Mycobacterium tuberculosis

-

0.2%, 1.5fold increase in activity

659667