2.4.99.20: 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

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For detailed information about 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase, go to the full flat file.

Reaction

nicotinate-adenine dinucleotide phosphate

Synonyms

2'-phospho-cyclic-ADP-ribose transferase, ADP-ribosyl cyclase 1, ADPRC 1, BST1, CD38, diphosphopyridine nucleosidase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.99 Transferring other glycosyl groups

2.4.99.20 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

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Results	in table
639	AA Sequence
1	Cloned(Commentary)
2	Crystallization (Commentary)
1	Expression
7	General Information
5	IC50 Value
6	Inhibitors
3	KM Value [mM]
7	Localization
2	Natural Substrates/ Products (Substrates)
15	Organism
1	Pathway
12	PDB ID
1	pH Optimum
6	Protein Variants
6	Reaction
15	Reference
8	Source Tissue
4	Specific Activity [micromol/min/mg]
33	Substrates and Products (Substrate)
14	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Systematic Name

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Systematic Name on EC 2.4.99.20 - 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase

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NADP+:nicotinate ADP-ribosyltransferase

This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2'-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.