2.4.2.B4: (KDO)2-lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase

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For detailed information about (KDO)2-lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase, go to the full flat file.

Reaction

(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->4)-(3-deoxy-alpha-D-manno-oct-2-ulopyranosylonate)-(2->6)-2-deoxy-2-{[(3R)-3-hydroxytetradecanoyl]amino}-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose

4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate

Synonyms

L-Ara4N transferase, yfbI

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.B4 (KDO)2-lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase

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1	Cloned(Commentary)
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1	Natural Substrates/ Products (Substrates)
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1	pH Optimum
1	Purification (Commentary)
1	Reaction
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2	Substrates and Products (Substrate)
19	Synonyms
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Natural Substrates Products

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Natural Substrates Products on EC 2.4.2.B4 - (KDO)2-lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase

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3-deoxy-alpha-D-manno-oct-2-ulopyranosyl-(2->4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate

3-deoxy-alpha-D-manno-oct-2-ulopyranosyl-(2->4)-3-deoxy-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-(4-amino-4-deoxy-alpha-L-arabinopyranosyl)phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-(4-amino-4-deoxy-alpha-L-arabinopyranosyl)phosphono-alpha-D-glucopyranose + undecaprenyl phosphate

Salmonella enterica subsp. enterica serovar Typhimurium

attachment of the cationic sugar 4-amino-4-deoxy-L-arabinose to lipid A is required for the maintenance of polymyxin resistance in Salmonella typhimurium. Lipid A molecules containing a Kdo disaccharide are modified with two 4-amino-4-deoxy-alpha-L-arabinose units (at the 1-phosphate moiety and at the 4'-phosphate moiety), indicating that the addition of L-Ara4N to the 4'-position is KDO-dependent. ArnT is a bifunctional glycosyltransferase in that it can incorporate two 4-amino-4-deoxy-alpha-L-arabinose units. Transfer to lipid A occurs on the periplasmic side of the inner membrane

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