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2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine nucleoside-5'-monophosphate + diphosphate
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine ribotide + diphosphate
2,6-diaminopurine 5-phosphoribosyl nucleotide + diphosphate
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminpurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminpurine 5'-phosphoribosyl nucleotide + diphosphate
2-aminobenzimidazole 5'-phosphoribosyl nucleotide + diphosphate
2-aminobenzimidazole + 5-phospho-alpha-D-ribose 1-diphosphate
very low activity
-
-
r
2-chloro-AMP + diphosphate
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
best substrate
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
2-fluoro-AMP + diphosphate
2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-fluoro-AMP + diphosphate
2-methoxyadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-methoxyadenosine 5'-monophosphate + diphosphate
-
-
-
r
2-methoxyadenosine 5'-phosphate + diphosphate
2-methoxyadenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
4-amino-5-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
4-amino-5-imidazolecarboxamide ribotide + diphosphate
-
-
-
-
?
4-aminopyrazolo-(3,4-d)-pyrimidine + 5-phospho-alpha-D-ribose 1-diphosphate
4-aminopyrazolo-(3,4-d)-pyrimidine ribotide + diphosphate
-
-
-
-
?
4-carbamoylimidazolium 5-olate + 5-phospho-alpha-D-ribose 1-diphosphate
4-carbamoylimidazolium 5-olate 5'-phosphate + diphosphate
-
low activity
-
-
?
5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
5-amino-4-imidazolecarboxamide ribotide + diphosphate
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
6-amino-2-hydroxypurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-amino-2-hydroxypurine ribotide + diphosphate
-
-
-
-
?
6-mercaptopurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-mercaptopurine ribotide + diphosphate
-
-
-
-
?
6-methoxyguanine + 5-phospho-alpha-D-ribose 1-diphosphate
6-methoxyguanosine 5'-monophosphate + diphosphate
-
-
-
r
6-methylpurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-methylpurine ribonucleoside-5'-monophosphate + diphosphate
-
-
-
r
6-methylpurine + 5-phospho-alpha-D-ribose 1-diphosphate
6-methylpurine ribotide + diphosphate
-
-
-
-
?
8-azaadenine + 5-phospho-alpha-D-ribose 1-diphosphate
8-azaadenosine 5'-phosphate + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
allopurinol + 5-phospho-alpha-D-ribose 1-diphosphate
?
-
-
-
r
AMP + diphosphate
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
benzyladenine + 5-phospho-alpha-D-ribose 1-diphosphate
benzyladenosine 5'-phosphate + diphosphate
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
IMP + diphosphate
-
at about 5.7% of the conversion rate for adenine
-
-
?
isopentenyladenine + 5-phospho-alpha-D-ribose 1-diphosphate
isopentenyladenosine 5'-phosphate + diphosphate
N1-methoxyadenine + 5-phospho-alpha-D-ribose 1-diphosphate
N1-methoxyadenosine 5'-monophosphate + diphosphate
-
-
-
r
N1-methyladenosine 5'-phosphate + diphosphate
N1-methyladenosine + 5-phospho-alpha-D-ribose 1-diphosphate
high activity
-
-
r
N6-benzyladenosine 5'-phosphate + diphosphate
N6-benzyladenine + 5-phospho-alpha-D-ribose 1-diphosphate
very low activity
-
-
r
N6-furfuryladenine + 5-phospho-alpha-D-ribose 1-diphosphate
N6-furfuryladenosine 5'-phosphate + diphosphate
-
-
-
-
?
xanthine + 5-phospho-alpha-D-ribose 1-diphosphate
xanthosine 5'-phosphate + diphosphate
-
-
-
-
?
zeatin + 5-phospho-alpha-D-ribose 1-diphosphate
zeatin riboside 5'-phosphate + diphosphate
additional information
?
-
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine nucleoside-5'-monophosphate + diphosphate
-
-
-
r
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine nucleoside-5'-monophosphate + diphosphate
-
-
-
r
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine nucleoside-5'-monophosphate + diphosphate
-
-
-
r
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine ribotide + diphosphate
-
specific for adenine or 2,6-diaminopurine
-
-
?
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine ribotide + diphosphate
-
-
-
-
?
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminopurine ribotide + diphosphate
-
-
-
-
?
2,6-diaminopurine 5-phosphoribosyl nucleotide + diphosphate
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
2,6-diaminopurine 5-phosphoribosyl nucleotide + diphosphate
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
2,6-diaminopurine 5-phosphoribosyl nucleotide + diphosphate
2,6-diaminopurine + 5-phospho-alpha-D-ribose 1-diphosphate
low activity
-
-
r
2,6-diaminpurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminpurine 5'-phosphoribosyl nucleotide + diphosphate
-
-
-
r
2,6-diaminpurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminpurine 5'-phosphoribosyl nucleotide + diphosphate
-
-
-
r
2,6-diaminpurine + 5-phospho-alpha-D-ribose 1-diphosphate
2,6-diaminpurine 5'-phosphoribosyl nucleotide + diphosphate
-
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
-
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
-
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
-
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
-
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
-
-
-
r
2-chloroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-chloro-AMP + diphosphate
-
-
-
r
2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-fluoro-AMP + diphosphate
-
-
-
r
2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-fluoro-AMP + diphosphate
-
-
-
r
2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-fluoro-AMP + diphosphate
-
-
-
r
2-fluoroadenine + 5-phospho-alpha-D-ribose 1-diphosphate
2-fluoro-AMP + diphosphate
-
-
-
r
5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
5-amino-4-imidazolecarboxamide ribotide + diphosphate
-
-
-
-
?
5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
5-amino-4-imidazolecarboxamide ribotide + diphosphate
-
-
-
?
5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
5-amino-4-imidazolecarboxamide ribotide + diphosphate
-
no activity
-
-
?
5-amino-4-imidazolecarboxamide + 5-phospho-alpha-D-ribose 1-diphosphate
5-amino-4-imidazolecarboxamide ribotide + diphosphate
-
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
enzyme deficiency leads to severe renal failure, overview
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
the enzyme is involved in the salvage of adenosine, overview
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
the enzyme is involved in the salvage of adenosine, overview
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
-
-
-
?
5-phospho-alpha-D-ribosyl-1-diphosphate + adenine
AMP + diphosphate
-
the enzyme is involved in the salvage of adenosine, overview
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
best acceptor substrate
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
isoform APT1 shows 100% activity with adenine
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
equilibrium lies far in the direction of nucleotide synthesis
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
adenine salvage enzyme
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
specific for adenine or 2,6-diamino-purine
5'-AMP
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
enzyme mediates the translocation of adenine into the cell as AMP
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
necessary for appropriate regulation of purine de novo biosynthesis
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
ordered substrate binding in the reverse reaction with AMP bound first followed by diphosphate
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
substrate binding structure
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
best acceptor substrate
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
highly specific for the donor substrate
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
human APRT deficiency results in serious kidney illness such as nephrolithiasis, interstitial nephritis, and chronic renal failure as a result of 2,8-dihydroxyadenine precipitation in the renal interstitium
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
binding to hAPRT is substrate shape-specific in the forward reaction, whereas it is base-specific in the reverse reaction
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
human APRT catalyzes the transformation of adenine into AMP and vice versa
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
substrate binding structure
AMP is bound in the low energy anti conformation with the ribose in the 2' endo conformation
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
strong preference for adenine as substrate over the 6-oxopurine bases, hypoxanthine and guanine
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
strong preference for adenine as substrate over the 6-oxopurine bases, hypoxanthine and guanine
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
diphosphate does not bind at the active site, but near the N-terminal side at Arg69
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
transfer to N9 of adenine
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?, r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
transfer to N9 of adenine
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?, r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
transfer to N9 of adenine
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
may play a role in maintaining the supply of adequate levels of active cytokinin
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
key enzyme that converts AMP in the purine salvage pathway. TaAPT2 gene may be related to the fertility alteration and abortion of pollen development
-
-
?
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
-
r
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
AMP + diphosphate
-
-
-
?
AMP + diphosphate
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
AMP + diphosphate
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
AMP + diphosphate
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
AMP + diphosphate
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
adenine binds to only one of the two subunits, leaving the adjacent adenine-free binding pockets occupied by a symmetry-related Tyr107 side chain, suggesting subunit-sequential catalytic site activity
-
-
?
AMP + diphosphate
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
?
AMP + diphosphate
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
adenine binds to only one of the two subunits, leaving the adjacent adenine-free binding pockets occupied by a symmetry-related Tyr107 side chain, suggesting subunit-sequential catalytic site activity
-
-
?
AMP + diphosphate
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
AMP + diphosphate
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
AMP + diphosphate
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
AMP + diphosphate
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
benzyladenine + 5-phospho-alpha-D-ribose 1-diphosphate
benzyladenosine 5'-phosphate + diphosphate
-
-
-
-
?
benzyladenine + 5-phospho-alpha-D-ribose 1-diphosphate
benzyladenosine 5'-phosphate + diphosphate
-
-
-
?
benzyladenine + 5-phospho-alpha-D-ribose 1-diphosphate
benzyladenosine 5'-phosphate + diphosphate
-
N6-benzyladenine
-
-
?
isopentenyladenine + 5-phospho-alpha-D-ribose 1-diphosphate
isopentenyladenosine 5'-phosphate + diphosphate
-
-
-
-
?
isopentenyladenine + 5-phospho-alpha-D-ribose 1-diphosphate
isopentenyladenosine 5'-phosphate + diphosphate
-
-
-
?
isopentenyladenine + 5-phospho-alpha-D-ribose 1-diphosphate
isopentenyladenosine 5'-phosphate + diphosphate
-
N6-(delta-isopentenyl)adenine
-
-
?
zeatin + 5-phospho-alpha-D-ribose 1-diphosphate
zeatin riboside 5'-phosphate + diphosphate
-
-
-
?
zeatin + 5-phospho-alpha-D-ribose 1-diphosphate
zeatin riboside 5'-phosphate + diphosphate
isoform APT4 shows about 38% activity with zeatin
-
-
?
zeatin + 5-phospho-alpha-D-ribose 1-diphosphate
zeatin riboside 5'-phosphate + diphosphate
isoform APT5 shows 100% activity with zeatin
-
-
?
zeatin + 5-phospho-alpha-D-ribose 1-diphosphate
zeatin riboside 5'-phosphate + diphosphate
isoforms APT1 shows 100% activity with zeatin
-
-
?
additional information
?
-
isoform APT2 is nearly inactive with adenine and zeatin
-
-
?
additional information
?
-
isoform APT2 is nearly inactive with adenine and zeatin
-
-
?
additional information
?
-
isoform APT2 is nearly inactive with adenine and zeatin
-
-
?
additional information
?
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isoform APT2 is nearly inactive with adenine and zeatin
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-
?
additional information
?
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isoform APT4 is nearly inactive with adenine
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-
?
additional information
?
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isoform APT4 is nearly inactive with adenine
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-
?
additional information
?
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isoform APT4 is nearly inactive with adenine
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-
?
additional information
?
-
isoform APT4 is nearly inactive with adenine
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-
?
additional information
?
-
isoform APT5 is nearly inactive with adenine
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-
?
additional information
?
-
isoform APT5 is nearly inactive with adenine
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-
?
additional information
?
-
isoform APT5 is nearly inactive with adenine
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-
?
additional information
?
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isoform APT5 is nearly inactive with adenine
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-
?
additional information
?
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APRT differentiates adenine from other purines
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-
-
additional information
?
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APRT differentiates adenine from other purines
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-
-
additional information
?
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no activity with hypoxanthine, guanine, cytosine
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-
?
additional information
?
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no substrate: adenosine
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-
?
additional information
?
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-
no donor substrates: D-ribose 5-phosphate, ribose 1-phosphate
-
-
?
additional information
?
-
-
no substrate: hypoxanthine,guanine
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-
?
additional information
?
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-
at 0°C in the absence of Mg2+ but in presence of substrates the enzyme catalyzes a rapid and limited synthesis of AMP
-
-
?
additional information
?
-
although hypoxanthine and adenine have the same chemical skeleton, which differs only by a hydroxyl instead of an amine at the C6 position away from the reactive N9 nitrogen, adenine seems to be the only purine metabolized by hAPRT
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-
-
additional information
?
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although hypoxanthine and adenine have the same chemical skeleton, which differs only by a hydroxyl instead of an amine at the C6 position away from the reactive N9 nitrogen, adenine seems to be the only purine metabolized by hAPRT
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-
-
additional information
?
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both the PRPP and ADE substrates are well ordered in all four subunits of the enzyme's crystal asymmetric unit, substrates' binding structures, overview. Residue Tyr105 favors the forward reaction. Tyr105 is in contact with both adenine and PRPP substrates in the closed conformation of the flexible loop. It might therefore play a role in the enzyme catalytic processes
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-
-
additional information
?
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-
both the PRPP and ADE substrates are well ordered in all four subunits of the enzyme's crystal asymmetric unit, substrates' binding structures, overview. Residue Tyr105 favors the forward reaction. Tyr105 is in contact with both adenine and PRPP substrates in the closed conformation of the flexible loop. It might therefore play a role in the enzyme catalytic processes
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-
-
additional information
?
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induced change in the APT2 expression pattern in young panicles may mediate, at least in part, thermosensitive genic male sterility in the cultivar Annong S-1
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?
additional information
?
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induced change in the APT2 expression pattern in young panicles may mediate, at least in part, thermosensitive genic male sterility in the cultivar Annong S-1
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-
?
additional information
?
-
APRT from Thermus thermophilus is known to have broad specificity in relation to adenine analogues, while it shows no significant catalytic activity if stereoisomers of PRPP are used as a substrate, narrow PRPP analogue specificity. One of the key factors determining the substrate specificity of an enzyme is its structure and the conformation of its active site in particular. Enzyme ligand interaction analysis
-
-
-
additional information
?
-
-
APRT from Thermus thermophilus is known to have broad specificity in relation to adenine analogues, while it shows no significant catalytic activity if stereoisomers of PRPP are used as a substrate, narrow PRPP analogue specificity. One of the key factors determining the substrate specificity of an enzyme is its structure and the conformation of its active site in particular. Enzyme ligand interaction analysis
-
-
-
additional information
?
-
no activity with 6-oxopurines (7-deazaxanthine and 7-deaza-6-hydroxypurine), 6-thiopurines (6-mercaptopurine), and 6-halopurines (6-chloropurine)
-
-
-
additional information
?
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not only adenine but also a number of its derivatives, including 2-chloro- and 2-fluoroadenine, 2-methoxyadenine, N1-methoxyadenine, and 2,6-diaminpurine, are substrates of the enzyme
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-
-
additional information
?
-
purine nucleotide synthesis using TthAPRT and TthHPRT (EC 2.4.2.8). No or poor activity with 8-azaguanine, thymine, 1,2,4-triazole-3-carboxamide, and 1,2,4-triazole-3-carboxy-N-methylamide
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-
-
additional information
?
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substrate specificity, overview. TtAPRT2 can use adenine as acceptor for NMP synthesis. But neither guanine nor hypoxanthine or xanthine are recognized as substrates by TtAPRT2
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-
-
additional information
?
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the enzyme APRT is specific for adenine, very poor activity with guanine, hypoxanthine, and xanthine
-
-
-
additional information
?
-
the enzyme APRT is specific for adenine, very poor activity with guanine, hypoxanthine, and xanthine
-
-
-
additional information
?
-
-
the enzyme APRT is specific for adenine, very poor activity with guanine, hypoxanthine, and xanthine
-
-
-
additional information
?
-
the enzyme encoded by gene TT_C1249 exhibits no detectable activity toward adenine, guanine, hypoxanthine, or xanthine. TTC1249 is a homologue of APRT (APRTh). Lack of activity of APRTh may be due to the replacement of the residues involved in binding the monophosphate of nucleotide
-
-
-
additional information
?
-
the enzyme encoded by gene TT_C1249 exhibits no detectable activity toward adenine, guanine, hypoxanthine, or xanthine. TTC1249 is a homologue of APRT (APRTh). Lack of activity of APRTh may be due to the replacement of the residues involved in binding the monophosphate of nucleotide
-
-
-
additional information
?
-
-
the enzyme encoded by gene TT_C1249 exhibits no detectable activity toward adenine, guanine, hypoxanthine, or xanthine. TTC1249 is a homologue of APRT (APRTh). Lack of activity of APRTh may be due to the replacement of the residues involved in binding the monophosphate of nucleotide
-
-
-
additional information
?
-
substrate specificity, overview. TtAPRT2 can use adenine as acceptor for NMP synthesis. But neither guanine nor hypoxanthine or xanthine are recognized as substrates by TtAPRT2
-
-
-
additional information
?
-
no activity with 6-oxopurines (7-deazaxanthine and 7-deaza-6-hydroxypurine), 6-thiopurines (6-mercaptopurine), and 6-halopurines (6-chloropurine)
-
-
-
additional information
?
-
not only adenine but also a number of its derivatives, including 2-chloro- and 2-fluoroadenine, 2-methoxyadenine, N1-methoxyadenine, and 2,6-diaminpurine, are substrates of the enzyme
-
-
-
additional information
?
-
the enzyme APRT is specific for adenine, very poor activity with guanine, hypoxanthine, and xanthine
-
-
-
additional information
?
-
the enzyme APRT is specific for adenine, very poor activity with guanine, hypoxanthine, and xanthine
-
-
-
additional information
?
-
APRT from Thermus thermophilus is known to have broad specificity in relation to adenine analogues, while it shows no significant catalytic activity if stereoisomers of PRPP are used as a substrate, narrow PRPP analogue specificity. One of the key factors determining the substrate specificity of an enzyme is its structure and the conformation of its active site in particular. Enzyme ligand interaction analysis
-
-
-
additional information
?
-
the enzyme encoded by gene TT_C1249 exhibits no detectable activity toward adenine, guanine, hypoxanthine, or xanthine. TTC1249 is a homologue of APRT (APRTh). Lack of activity of APRTh may be due to the replacement of the residues involved in binding the monophosphate of nucleotide
-
-
-
additional information
?
-
the enzyme encoded by gene TT_C1249 exhibits no detectable activity toward adenine, guanine, hypoxanthine, or xanthine. TTC1249 is a homologue of APRT (APRTh). Lack of activity of APRTh may be due to the replacement of the residues involved in binding the monophosphate of nucleotide
-
-
-
additional information
?
-
substrate specificity, overview. TtAPRT2 can use adenine as acceptor for NMP synthesis. But neither guanine nor hypoxanthine or xanthine are recognized as substrates by TtAPRT2
-
-
-
additional information
?
-
no activity with 6-oxopurines (7-deazaxanthine and 7-deaza-6-hydroxypurine), 6-thiopurines (6-mercaptopurine), and 6-halopurines (6-chloropurine)
-
-
-
additional information
?
-
not only adenine but also a number of its derivatives, including 2-chloro- and 2-fluoroadenine, 2-methoxyadenine, N1-methoxyadenine, and 2,6-diaminpurine, are substrates of the enzyme
-
-
-
additional information
?
-
the enzyme APRT is specific for adenine, very poor activity with guanine, hypoxanthine, and xanthine
-
-
-
additional information
?
-
the enzyme APRT is specific for adenine, very poor activity with guanine, hypoxanthine, and xanthine
-
-
-
additional information
?
-
APRT from Thermus thermophilus is known to have broad specificity in relation to adenine analogues, while it shows no significant catalytic activity if stereoisomers of PRPP are used as a substrate, narrow PRPP analogue specificity. One of the key factors determining the substrate specificity of an enzyme is its structure and the conformation of its active site in particular. Enzyme ligand interaction analysis
-
-
-
additional information
?
-
the enzyme encoded by gene TT_C1249 exhibits no detectable activity toward adenine, guanine, hypoxanthine, or xanthine. TTC1249 is a homologue of APRT (APRTh). Lack of activity of APRTh may be due to the replacement of the residues involved in binding the monophosphate of nucleotide
-
-
-
additional information
?
-
the enzyme encoded by gene TT_C1249 exhibits no detectable activity toward adenine, guanine, hypoxanthine, or xanthine. TTC1249 is a homologue of APRT (APRTh). Lack of activity of APRTh may be due to the replacement of the residues involved in binding the monophosphate of nucleotide
-
-
-
additional information
?
-
-
no substrate: hypoxanthine,guanine
-
-
?