2.4.2.7: adenine phosphoribosyltransferase

This is an abbreviated version!
For detailed information about adenine phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.7

2.4.2.7

purine

hamster

hypoxanthine

salvage

2,8-dihydroxyadenine

ovary

erythrocyte

hypoxanthine-guanine

nucleoside

stone

guanine

urolithiasis

allopurinol

deaminase

xanthine

hgprt

heterozygosity

inosine

uric

lesch-nyhan

nephrolithiasis

hemizygous

2,6-diaminopurine

phosphoribosyltransferases

imp

5-phosphoribosyl-1-pyrophosphate

gout

radiolucent

calculi

transversions

crystalluria

hprt-deficient

repair-deficient

lithiasis

hgprtase

synthesis

drug development

hemolysates

3.5.4.4

repair-proficient

2.7.1.20

medicine

Reaction

Synonyms

adenine phosphoribosyl transferase, adenine phosphoribosylpyrophosphate transferase, adenine phosphoribosyltransferase, adenine phosphoribosyltransferase 2, adenione PRTase, adenosine phosphoribosyltransferase, adenylate pyrophosphorylase, adenylic pyrophosphorylase, AMP pyrophosphorylase, AMP-pyrophosphate phosphoribosyltransferase, AMP:pyrophosphate phospho-D-ribosyltransferase, APRT, APRT1, APRT2, APRTase, APRTh, apT, APT1, APT2, APT4, APT5, ApTR, FtAPRT, gpT-1, hAPRT, More, phosphoribosyltransferase, adenine, ScAPRT, SmAPRT1, Smp_054360, SSO2342, transphosphoribosidase, TtAPRT2, TTC1249, TTC1250, TTH1250, TTHA1614, TthAPRT, TthHB27APRT, TT_C1249, TT_C1250, type I PRT

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.7 adenine phosphoribosyltransferase

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Results	in table
5	Activating Compound
33808	AA Sequence
3	Application
1	CAS Registry Number
27	Cloned(Commentary)
15	Crystallization (Commentary)
1379	Disease/ Diagnostics
9	Expression
67	General Information
11	General Stability
1	IC50 Value
121	Inhibitors
10	kcat/KM [mM/s]
36	Ki Value [mM]
94	KM Value [mM]
9	Localization
77	Metals/Ions
36	Molecular Weight [Da]
46	Natural Substrates/ Products (Substrates)
257	Organism
9	Pathway
79	PDB ID
41	pH Optimum
7	pH Range
3	pI Value
45	Protein Variants
40	Purification (Commentary)
12	Reaction
1	Reaction Type
92	Reference
55	Source Tissue
36	Specific Activity [micromol/min/mg]
13	Storage Stability
202	Substrates and Products (Substrate)
46	Subunits
146	Synonyms
1	Systematic Name
34	Temperature Optimum [°C]
1	Temperature Range [°C]
28	Temperature Stability [°C]
30	Turnover Number [1/s]

KI Value

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KI Value on EC 2.4.2.7 - adenine phosphoribosyltransferase

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2,6-diaminopurine

Plasmodium falciparum

638158

0.53

4-aminopteridine

Leishmania donovani

638004

0.017

4-aminopyrido(2,3-d)pyrimidine

Leishmania donovani

638004

0.95

4-aminopyrolo(2,3-d)pyrimidine

Leishmania donovani

638004

1.96

5-phosphoribose 1-diphosphate

Arabidopsis thaliana

at 37°C

638146

0.011

adenine

Saccharolobus solfataricus

Q97W95

pH 7.5, 60°C

729271

0.019 - 3.2

ADP

2 entries

0.0021 - 23.5

AMP

11 entries

0.344 - 0.574

ATP

2 entries

0.002

Cu2+

Hevea brasiliensis

638165

0.0087

D-2,5-dideoxy-2,5-imino-altritol 1,6-bisphosphate

Saccharomyces cerevisiae

P49435

pH 7.5, 25°C, recombinant enzyme

758562

0.51 - 1.79

diphosphate

3 entries

0.059 - 0.062

formycin AMP

2 entries

0.2

guanine

Leishmania donovani

above

638004

0.8

hypoxanthine

Leishmania donovani

above

638004

0.0002

immucillin AB

Saccharomyces cerevisiae

638171

0.0149

L-2,5-dideoxy-2,5-imino-altritol 1,6-bisphosphate

Saccharomyces cerevisiae

P49435

pH 7.5, 25°C, recombinant enzyme

758562

0.7

Mercaptopurine

Plasmodium falciparum

638158

5.4

Mg2+

Saccharolobus solfataricus

Q97W95

pH and temperature not specified in the publication

729271

0.8

xanthine

Leishmania donovani

above

638004

0.005

Zn2+

Hevea brasiliensis

638165