2.4.2.7: adenine phosphoribosyltransferase

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For detailed information about adenine phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.7

2.4.2.7

purine

hamster

hypoxanthine

salvage

2,8-dihydroxyadenine

ovary

erythrocyte

hypoxanthine-guanine

nucleoside

stone

guanine

urolithiasis

allopurinol

deaminase

xanthine

hgprt

heterozygosity

inosine

uric

lesch-nyhan

nephrolithiasis

hemizygous

2,6-diaminopurine

phosphoribosyltransferases

imp

5-phosphoribosyl-1-pyrophosphate

gout

radiolucent

calculi

transversions

crystalluria

hprt-deficient

repair-deficient

lithiasis

hgprtase

synthesis

drug development

hemolysates

3.5.4.4

repair-proficient

2.7.1.20

medicine

Reaction

Synonyms

adenine phosphoribosyl transferase, adenine phosphoribosylpyrophosphate transferase, adenine phosphoribosyltransferase, adenine phosphoribosyltransferase 2, adenione PRTase, adenosine phosphoribosyltransferase, adenylate pyrophosphorylase, adenylic pyrophosphorylase, AMP pyrophosphorylase, AMP-pyrophosphate phosphoribosyltransferase, AMP:pyrophosphate phospho-D-ribosyltransferase, APRT, APRT1, APRT2, APRTase, APRTh, apT, APT1, APT2, APT4, APT5, ApTR, FtAPRT, gpT-1, hAPRT, More, phosphoribosyltransferase, adenine, ScAPRT, SmAPRT1, Smp_054360, SSO2342, transphosphoribosidase, TtAPRT2, TTC1249, TTC1250, TTH1250, TTHA1614, TthAPRT, TthHB27APRT, TT_C1249, TT_C1250, type I PRT

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.7 adenine phosphoribosyltransferase

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Results	in table
5	Activating Compound
33808	AA Sequence
3	Application
1	CAS Registry Number
27	Cloned(Commentary)
15	Crystallization (Commentary)
1379	Disease/ Diagnostics
9	Expression
67	General Information
11	General Stability
1	IC50 Value
121	Inhibitors
10	kcat/KM [mM/s]
36	Ki Value [mM]
94	KM Value [mM]
9	Localization
77	Metals/Ions
36	Molecular Weight [Da]
46	Natural Substrates/ Products (Substrates)
257	Organism
9	Pathway
79	PDB ID
41	pH Optimum
7	pH Range
3	pI Value
45	Protein Variants
40	Purification (Commentary)
12	Reaction
1	Reaction Type
92	Reference
55	Source Tissue
36	Specific Activity [micromol/min/mg]
13	Storage Stability
202	Substrates and Products (Substrate)
46	Subunits
146	Synonyms
1	Systematic Name
34	Temperature Optimum [°C]
1	Temperature Range [°C]
28	Temperature Stability [°C]
30	Turnover Number [1/s]

Expression

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Expression on EC 2.4.2.7 - adenine phosphoribosyltransferase

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mutational HPRT deficiency leads to increased APRT expression and activity in MN9D cells, microarray analysis of HPRT-deficient MN9D cells, phenotype with increases in APRT and mRNAs for engrailed 1 and 2, En1 and En2, transcription factors, overview

Homo sapiens

703955

overexpression of APRT (pTREX-APRT) in benznidazole sensitive parasites, relative to the control parasites transfected with GFP (pTREX-GFP), confirmed by quantitative RT-PCR and northern blot analysis. 15.6fold and 4.6fold overexpressions are detected for the two different techniques, respectively

4 entries

the gene encoding adenine phosphoribosyltransferase (APRT) is downregulated by 5.2fold in the parasites resistant against benznidazole (Bz) and nifurtimox (Nfx), and its expression profile is confirmed by 2D electrophoresis analysis

4 entries