2.4.2.49: neamine phosphoribosyltransferase
This is an abbreviated version!
For detailed information about neamine phosphoribosyltransferase, go to the full flat file.
Reaction
Synonyms
btrL, neoM
ECTree
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General Information
General Information on EC 2.4.2.49 - neamine phosphoribosyltransferase
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metabolism
additional information
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BtrA, BtrL, BtrP, and BtrV proteins encoded in the butirosin biosynthetic gene cluster (btr) from Bacillus circulans SANK72073 are responsible for the O-ribosylation process leading to the formation of ribostamycin, a key intermediate in this, and related antibiotic biosynthetic pathways. Both BtrL and BtrP are responsible for the ribosylation of neamine, using 5-phosphoribosyl 1-diphosphate as the ribosyl donor via two discrete steps: with BtrL first catalyzes the phosphoribosylaion of neamine to form 5''-phosphoribostamycin, followed by a BtrP catalyzing the dephosphorylation to generate ribostamycin
metabolism
Niallia circulans SANK72073
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BtrA, BtrL, BtrP, and BtrV proteins encoded in the butirosin biosynthetic gene cluster (btr) from Bacillus circulans SANK72073 are responsible for the O-ribosylation process leading to the formation of ribostamycin, a key intermediate in this, and related antibiotic biosynthetic pathways. Both BtrL and BtrP are responsible for the ribosylation of neamine, using 5-phosphoribosyl 1-diphosphate as the ribosyl donor via two discrete steps: with BtrL first catalyzes the phosphoribosylaion of neamine to form 5''-phosphoribostamycin, followed by a BtrP catalyzing the dephosphorylation to generate ribostamycin
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