2.4.2.48: tRNA-guanine15 transglycosylase

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For detailed information about tRNA-guanine15 transglycosylase, go to the full flat file.

Reaction

Synonyms

archaeosine tRNA-guanine transglycosylase, archaeosine tRNAguanine transglycosylase, ArcTGT, multisite-specific archaeosine tRNA-guanine transglycosylase, Ta1493, TGT, transfer ribonucleic acid guanine15 transglycosylase, tRNA guanine15 transglycosidase, tRNA-guanine transglycosylase

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.48 tRNA-guanine15 transglycosylase

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Results	in table
1970	AA Sequence
6	Cloned(Commentary)
2	Crystallization (Commentary)
3	General Information
2	kcat/KM [mM/s]
3	KM Value [mM]
4	Metals/Ions
5	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
17	Organism
2	Pathway
4	pH Optimum
1	Protein Variants
5	Purification (Commentary)
1	Reaction
14	Reference
3	Specific Activity [micromol/min/mg]
17	Substrates and Products (Substrate)
5	Subunits
23	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
2	Turnover Number [1/s]

General Information

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General Information on EC 2.4.2.48 - tRNA-guanine15 transglycosylase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Methanocaldococcus jannaschii

Q57878

biogenetic relationship of queuosine and archaeosine, overview. The elements necessary for tRNA recognition by the enzyme are not unique to archaeal tRNA

719802

metabolism

Methanocaldococcus jannaschii

Q57878

GTP is apparently the primary precursor in the biosynthesis of queuosine, which in a series of steps is converted to 7-(cyano)-7-deazaguanine, i.e. preQ0. PreQ0 is then reduced to PreQ1, and preQ1 is subsequently inserted into the tRNA by the enzyme TGT in a transglycosylation reaction in which the genetically encoded base guanine is eliminated

719802

additional information

Methanocaldococcus jannaschii

Q57878

the nature of the temperature dependence is consistent with a requirement for some degree of tRNA tertiary structure in order for recognition by the enzyme to occur

719802