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2.4.2.45: decaprenyl-phosphate phosphoribosyltransferase

This is an abbreviated version!
For detailed information about decaprenyl-phosphate phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.45

Reaction

trans,octacis-decaprenyl phosphate
+
5-phospho-alpha-D-ribose 1-diphosphate
=
trans,octacis-decaprenylphospho-beta-D-ribofuranose 5-phosphate
+
diphosphate

Synonyms

-phospho-alpha-D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase, 5-phospho-alpha-D-ribose 1-pyrophosphate:decaprenyl phosphate 5-phosphoribosyltransferase, 5-phospho-alpha-D-ribose-1-diphosphate: decaprenyl-phosphate, 5-phospho-alpha-D-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, 5-phospho-alpha-FS18 D-ribose-1-diphosphate:decaprenyl-phosphate 5-phosphoribosyltransferase, 5-phosphoribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase, 5-phosphoribosyltransferase, cg3189, DPPR synthase, MSMEG 6401, Rv3806, Rv3806c, ubiA

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.45 decaprenyl-phosphate phosphoribosyltransferase

Engineering

Engineering on EC 2.4.2.45 - decaprenyl-phosphate phosphoribosyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A35E
the mutant is associated with high-level ethambutol resistance and increases decaprenylphosphoryl-beta-D-arabinose levels
D77E
15% activity compared to the wild type enzyme
E195A
17% activity compared to the wild type enzyme
F176L
the mutation is associated with ethambutol resistance
F59A
94% activity compared to the wild type enzyme
F62A
72% activity compared to the wild type enzyme
G165C
the mutant is associated with high-level ethambutol resistance and increases decaprenylphosphoryl-beta-D-arabinose levels
H84L
15% activity compared to the wild type enzyme
K174T
the mutation is associated with ethambutol resistance
N29A
18% activity compared to the wild type enzyme
N73Q
15% activity compared to the wild type enzyme
R201A
1% activity compared to the wild type enzyme
R22L
10% activity compared to the wild type enzyme
W175C
the mutation is associated with ethambutol resistance
F176L
-
the mutation is associated with ethambutol resistance
-
K174T
-
the mutation is associated with ethambutol resistance
-
W175C
-
the mutation is associated with ethambutol resistance
-