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2.4.2.44: S-methyl-5'-thioinosine phosphorylase

This is an abbreviated version!
For detailed information about S-methyl-5'-thioinosine phosphorylase, go to the full flat file.

Reaction

S-methyl-5'-thioinosine
+
phosphate
=
hypoxanthine
+
S-methyl-5-thio-alpha-D-ribose 1-phosphate

Synonyms

methylthioinosine phosphorylase, MTI phosphorylase, MTIP, PA3004

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.44 S-methyl-5'-thioinosine phosphorylase

Crystallization

Crystallization on EC 2.4.2.44 - S-methyl-5'-thioinosine phosphorylase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystallization of recombinant enzyme (9 mg/ml) in 50 mM HEPES, pH 7.4, 30% polyethylene glycol monomethyl ether 2000, 0.1 M potassium thiocyanate in the presence of 5 mM S-methyl-5'-thioinosine and 5 mM sulfate by sitting-drop vapor diffusion. Crystal structure of the enzyme in complex with hypoxanthine is determined to 2.8 A resolution
the crystal structure of P. aeruginosa MTIP (PaMTIP) in complex with hypoxanthine is determined to 2.8 A resolution and reveals a three-fold symmetric homotrimer