2.4.2.43: lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase
This is an abbreviated version!
For detailed information about lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase, go to the full flat file.
Word Map on EC 2.4.2.43
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2.4.2.43
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photosystem
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synechocystis
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cyanobacterium
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polymyxin
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time-resolved
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photoautotrophically
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elongatus
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epr
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aeruginosa
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thermosynechococcus
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typhimurium
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polymyxin-resistance
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light-regulated
- 2.4.2.43
-
photosystem
-
synechocystis
-
cyanobacterium
-
polymyxin
-
time-resolved
-
photoautotrophically
-
elongatus
- epr
- aeruginosa
-
thermosynechococcus
- typhimurium
-
polymyxin-resistance
-
light-regulated
Reaction
Synonyms
4-amino-4-deoxy-L-arabinose transferase, aminoarabinose transferase, arnT, L-Ara4N transferase, undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase
ECTree
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General Information
General Information on EC 2.4.2.43 - lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase
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malfunction
LpxT-dependent lipid A modification is not restored in arnT or eptA mutants
physiological function
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ArnT confers resistance to the antibiotic polymyxin in Salmonella typhimurium and Escherichia coli through the modification of lipid A, a major component of the outer surface of Gram-negative bacteria. ArnT transfers a neutral aminoarabinose moiety onto the negative phosphate groups of lipid A, reducing the surface charge of the bacteria and preventing cationic peptides such as polymyxin from electrostatically recognizing and killing the bacteria. Only small amounts of ArnT are necessary to provide resistance against polymyxin to the bacterial cell