2.4.2.38: glycoprotein 2-beta-D-xylosyltransferase

This is an abbreviated version!
For detailed information about glycoprotein 2-beta-D-xylosyltransferase, go to the full flat file.

Reaction

Synonyms

beta 1,2-xylosyltransferase, beta-1,2-xylosyltransferase, beta-1,2-XylT, beta-1,4-mannosylglycoprotein beta-1,2-xylosyltransferase, beta1,2-xylosyltransferase, CAP3, Cryptococcal xylosyltransferase, cryptococcus xylosyltransferase 1, CXT1, Cxt1p, CXT1p homolog, RCN11, XT-I, XT1, Xt1p, Xyl-beta-1,2-transferase, xylan xylosyltransferase1, xylosyltransferase I, xylosyltransferase-I, XylT, XYLT1, XYXT1

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.38 glycoprotein 2-beta-D-xylosyltransferase

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Results	in table
46	AA Sequence
8	Application
1	CAS Registry Number
15	Cloned(Commentary)
44	Disease/ Diagnostics
4	Expression
4	General Information
1	General Stability
14	Inhibitors
2	Ki Value [mM]
2	KM Value [mM]
13	Localization
11	Metals/Ions
8	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
40	Organism
3	Pathway
8	pH Optimum
1	pH Range
2	pH Stability
4	Posttranslational Modification
12	Protein Variants
5	Purification (Commentary)
4	Reaction
19	Reaction Type
37	Reference
14	Source Tissue
5	Specific Activity [micromol/min/mg]
3	Storage Stability
53	Substrates and Products (Substrate)
4	Subunits
68	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 2.4.2.38 - glycoprotein 2-beta-D-xylosyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

UDP-alpha-D-xylose + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein]

UDP + N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-[beta-D-Xyl-(1->2)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein]

Nicotiana benthamiana

-

-

759928

-

-

?

UDP-alpha-D-xylose + xylan

?

Oryza sativa Japonica Group

Q5Z8T8

the enzyme adds side chain xylosyl residues directly to the xylan backbone at 2-O

759938

-

-

?

UDP-D-xylose + galactoxylomannan

UDP + [beta-D-xylose-(1,2)]-galactoxylomannan

Cryptococcus neoformans

Q5K8R6

-

693051

JEC21/cxt1delta and CAP67/cxt1delta lacking CXT1p: almost complete loss of beta-xylose residues (1,2)-linked to mannose, unchanged amounts of beta-xylose (1,3)-linked to galactose

-

?

UDP-D-xylose + galactoxylomannan

UDP + [beta-D-xylosyl-(1,2)]-galactoxylomannan

Cryptococcus neoformans

Q5K8R6

-

692993

-

-

?

UDP-D-xylose + glucuronoxylomannan

UDP + [beta-D-xylose-(1,2)]-glucuronoxylomannan

Cryptococcus neoformans

Q5K8R6

-

693051

JEC21/cxt1delta and CAP67/cxt1delta lacking CXT1p: 30% decrease in amount of xylose, 39% decrease in O-2 xylose-substituted mannose, 31.5% increase in O-2-unsubstituted mannose, loss of 1/3 of beta-(1,2)-linked xylose, revealed by NMR analyses

-

?

UDP-D-xylose + glucuronoxylomannan

UDP + [beta-D-xylosyl-(1,2)]-glucuronoxylomannan

Cryptococcus neoformans

Q5K8R6

-

692993

-

-

?

UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine

UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine

2 entries

UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine

UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine

3 entries

UDP-xylose + mannosyl-alpha-(1,3)-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide

UDP + mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide

Cryptococcus neoformans

Q5K8R6

no transfer of xylose residues onto substrate in absence of Cxt1p (JEC21/cxt1delta) as revealed by mass spectrometry and HPTLC, mannosyl-alpha-(1,3)-mannose-alpha motif also present in substrates for capsule polysaccharide synthesis

692134

core structure of glycosylinositol phosphorylceramides, GIPCs

-

?

UDP-xylose + mannosyl-alpha-(1,6)-mannosyl-alpha-(1,3)-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide

UDP + mannosyl-alpha-(1,6)-mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide

Cryptococcus neoformans

Q5K8R6

no transfer of xylose residues onto substrate in absence of Cxt1p (JEC21/cxt1delta) as revealed by mass spectrometry and HPTLC

692134

-

-

?

additional information

?

-

15 entries

UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine

UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine

Arabidopsis thaliana

-

-

660192

-

-

?

UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine

UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-[beta-D-xylosyl-(1,2)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine

Arabidopsis thaliana

Q9LDH0

-

660169

-

-

?

UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine

UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine

Arabidopsis thaliana

Q9LDH0

-

737023

-

-

?

UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine

UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine

Nicotiana benthamiana

-

-

730079

-

-

?

UDP-D-xylose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine

UDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine

Oryza sativa

-

-

737044

-

-

?

additional information

?

-

Arabidopsis thaliana

-

the enzyme is involved in the biosynthesis of glycoprotein-bound N-glycans in plants and acts at multiple stages of the plant N-glycosylation pathway, overview

671831

-

-

?

additional information

?

-

Cryptococcus neoformans

Q5K8R6

preferred substrate depends on wild-type strain, strain JEC21: both products detectable (mannosyl-alpha-(1,6)-mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide and mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide) at a ratio of approximately 1:1

692134

-

-

?

additional information

?

-

Cryptococcus neoformans

-

preferred substrate depends on wild-type strain, strain JEC21: both products detectable (mannosyl-alpha-(1,6)-mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide and mannosyl-alpha-(1,3)-[xylosyl-beta-(1,2)]-mannosyl-alpha-(1,4)-galactosyl-beta-(1,6)-mannosyl-alpha-(1,2)-inositol phosphorylceramide) at a ratio of approximately 1:1

692134

-

-

?

additional information

?

-

Cryptococcus neoformans

-

transfer of beta (1,2)-xylose, capsule synthesis

692993

-

-

?

additional information

?

-

Cryptococcus neoformans

Q5K8R6

transfer of beta (1,2)-xylose, capsule synthesis

692993

-

-

?

additional information

?

-

Cryptococcus neoformans

Q5K8R6

transfer of beta (1,2)-xylose, synthesis of capsule polysaccharides and fungi-specific glycosphingolipids

692134

-

-

?

additional information

?

-

Cryptococcus neoformans

-

transfer of beta (1,2)-xylose, synthesis of capsule polysaccharides and fungi-specific glycosphingolipids

692134

-

-

?

additional information

?

-

Lymnaea stagnalis

-

probably involved in the biosynthesis of the inner part of hemocyanin glycans

394590

-

-

?

additional information

?

-

Medicago sativa

-

-

694620

strongly reduced biosynthesis of beta 1,2-xylose-containing glycoepitopes upon knock-down of endogenous beta 1,2-xylosyltransferase using sense, antisense and RNA interference approaches

-

?

additional information

?

-

Nicotiana benthamiana

-

-

694619

strongly reduced biosynthesis of beta 1,2-xylose-containing glycoepitopes upon knock-down of endogenous beta 1,2-xylosyltransferase using RNA interference approaches

-

?

additional information

?

-

Oryza sativa

Q6ZFH6

enzyme is involved in N-glycan biosynthesis, quantification and structure analysis of N-glycans in rice leaves

660200

-

-

?

additional information

?

-

Oryza sativa

-

enzyme is involved in N-glycan biosynthesis, quantification and structure analysis of N-glycans in rice leaves

660200

-

-

?

additional information

?

-

Oryza sativa Japonica Group

Q5Z8T8

the enzyme is unable to add xylosyl residues onto the arabinosyl side chains of xylan

759938

-

-

-

additional information

?

-

Zea mays

Q2UVB3

the enzyme is involved in the modification of asparagine-linked oligosaccharides of maize glycoproteins with beta1,2-xylose sugar residues

676375

-

-

?

additional information

?

-

Zea mays

-

the enzyme is involved in the modification of asparagine-linked oligosaccharides of maize glycoproteins with beta1,2-xylose sugar residues

676375

-

-

?