2.4.2.38: glycoprotein 2-beta-D-xylosyltransferase
This is an abbreviated version!
For detailed information about glycoprotein 2-beta-D-xylosyltransferase, go to the full flat file.
Word Map on EC 2.4.2.38
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2.4.2.38
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proteoglycans
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glycosaminoglycans
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desbuquois
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alpha1,3-fucosyltransferase
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laxity
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2.4.2.26
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udp-xylose
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chain-initiating
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xylosylated
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medicine
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alpha1,3-fucose
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biotechnology
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beta1,2-xylose
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o-xylosyltransferase
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synthesis
- 2.4.2.38
- proteoglycans
- glycosaminoglycans
-
desbuquois
-
alpha1,3-fucosyltransferase
-
laxity
-
2.4.2.26
- udp-xylose
-
chain-initiating
-
xylosylated
- medicine
-
alpha1,3-fucose
- biotechnology
-
beta1,2-xylose
-
o-xylosyltransferase
- synthesis
Reaction
Synonyms
beta 1,2-xylosyltransferase, beta-1,2-xylosyltransferase, beta-1,2-XylT, beta-1,4-mannosylglycoprotein beta-1,2-xylosyltransferase, beta1,2-xylosyltransferase, CAP3, Cryptococcal xylosyltransferase, cryptococcus xylosyltransferase 1, CXT1, Cxt1p, CXT1p homolog, RCN11, XT-I, XT1, Xt1p, Xyl-beta-1,2-transferase, xylan xylosyltransferase1, xylosyltransferase I, xylosyltransferase-I, XylT, XYLT1, XYXT1
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General Information
General Information on EC 2.4.2.38 - glycoprotein 2-beta-D-xylosyltransferase
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malfunction
metabolism
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the enzyme catalyzes the initial step of glycosaminoglycan biosynthesis
physiological function
Xt1p has a defined role in capsule biosynthesis
loss of XT1 does not affect in vitro growth of mutant cells or general morphology of their capsules. The two main capsule polysaccharides, glucuronoxylomannan and galactoxylomannan, both are missing beta1,2-xylose residues. Deletion of XT1 leads to attenuation of cryptococcal growth in a mouse model of infection
malfunction
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expression of the tomato beta1,2-xylosyltransferase is down-regulated by RNA interference in transgenic tomato plants. On the basis of IgE immunoblotting assays XylT-RNAi tomato fruits reveal a patient-specific reduction in IgE reactivity. Patients with tomato allergy have reduced mean wheal diameters in skin prick tests, demonstrating a reduced allergenic potential of XylT-RNAi tomato fruits in vivo