2.4.2.36: NAD+-diphthamide ADP-ribosyltransferase

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For detailed information about NAD+-diphthamide ADP-ribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.36

2.4.2.36

camp

cyclase

vibrio

mucosal

pertussis

adp-ribosylation

adenylate

forskolin

retrograde

gm1

ganglioside

aeruginosa

enterotoxin

iga

agonist

tracer

dorsal

prostaglandin

heat-labile

intranasal

dibutyryl

afferent

isoproterenol

adenylyl

g-proteins

innervation

gtp-binding

diphtheria

immunotoxins

anterograde

b-subunits

rostrally

toxigenic

ribosylation

pilus

toxin-induced

toxin-sensitive

pyrogenic

toxoid

8-bromo-camp

diarrheal

antitoxin

ventrolateral

peyer

exoenzyme

enterotoxigenic

gppnhp

preganglionic

drug development

wga-hrp

parabrachial

medicine

diagnostics

Reaction

diphthamide-[translation elongation factor 2]

N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]

Synonyms

(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-elongation factor 2, ADP-ribosyltransferase, cholera toxin, cholix, cholix toxin, chxA, CTB, diphthamide-specific ADPRT, diphthamide-specific mono-ADP-ribosylating toxin, EHI 155600, EhToxin-l, EhToxin-like, ExoA, ExoA(c), exotoxin A, mono(ADPribosyl)transferase, mono-ADP-ribosyltransferase, NAD(+)-diphthamide ADP-ribosyltransferase, NAD-diphthamide ADP-ribosyltransferase, NAD-diphthamide ADP-ribosyltransferase NAD-elongation factor 2 ADP-ribosyltransferase, NAD:elongation factor 2-adenosine diphosphate ribose-transferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.36 NAD+-diphthamide ADP-ribosyltransferase

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Results	in table
8	Activating Compound
41	AA Sequence
4	Application
1	CAS Registry Number
4	Cloned(Commentary)
1	Cofactor
4	Crystallization (Commentary)
2	General Information
9	IC50 Value
31	Inhibitors
8	Ki Value [mM]
41	KM Value [mM]
5	Localization
2	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
18	Organism
42	PDB ID
3	pH Optimum
1	Posttranslational Modification
45	Protein Variants
6	Purification (Commentary)
1	Reaction
2	Reaction Type
18	Reference
4	Source Tissue
21	Substrates and Products (Substrate)
5	Subunits
30	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
84	Turnover Number [1/s]

Systematic Name

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Systematic Name on EC 2.4.2.36 - NAD+-diphthamide ADP-ribosyltransferase

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NAD+:diphthamide-[translation elongation factor 2] N-(ADP-D-ribosyl)transferase

Diphtheria toxin and some other bacterial toxins catalyse this reaction, which inactivates translation elongation factor 2 (EF2). The acceptor is diphthamide, a unique modification of a histidine residue in the elongation factor found in archaebacteria and all eukaryotes, but not in eubacteria. cf. EC 2.4.2.31 NAD(P)+---protein-arginine ADP-ribosyltransferase. The relevant histidine of EF2 is His715 in mammals, His699 in yeast and His600 in Pyrococcus horikoshii.