2.4.2.36: NAD+-diphthamide ADP-ribosyltransferase
This is an abbreviated version!
For detailed information about NAD+-diphthamide ADP-ribosyltransferase, go to the full flat file.
Word Map on EC 2.4.2.36
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2.4.2.36
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camp
-
cyclase
-
vibrio
-
mucosal
-
pertussis
-
adp-ribosylation
-
adenylate
-
forskolin
-
retrograde
-
gm1
-
ganglioside
-
aeruginosa
-
enterotoxin
-
iga
-
agonist
-
tracer
-
dorsal
-
prostaglandin
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heat-labile
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intranasal
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dibutyryl
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afferent
-
isoproterenol
-
adenylyl
-
g-proteins
-
innervation
-
gtp-binding
-
diphtheria
-
immunotoxins
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anterograde
-
b-subunits
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rostrally
-
toxigenic
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ribosylation
-
pilus
-
toxin-induced
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toxin-sensitive
-
pyrogenic
-
toxoid
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8-bromo-camp
-
diarrheal
-
antitoxin
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ventrolateral
-
peyer
-
exoenzyme
-
enterotoxigenic
-
gppnhp
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preganglionic
-
drug development
-
wga-hrp
-
parabrachial
-
medicine
-
diagnostics
- 2.4.2.36
- camp
- cyclase
- vibrio
- mucosal
- pertussis
-
adp-ribosylation
- adenylate
- forskolin
-
retrograde
- gm1
- ganglioside
- aeruginosa
- enterotoxin
- iga
- agonist
-
tracer
-
dorsal
- prostaglandin
-
heat-labile
-
intranasal
-
dibutyryl
-
afferent
- isoproterenol
-
adenylyl
- g-proteins
-
innervation
-
gtp-binding
- diphtheria
- immunotoxins
-
anterograde
-
b-subunits
-
rostrally
-
toxigenic
-
ribosylation
- pilus
-
toxin-induced
-
toxin-sensitive
-
pyrogenic
- toxoid
- 8-bromo-camp
-
diarrheal
- antitoxin
-
ventrolateral
-
peyer
-
exoenzyme
-
enterotoxigenic
-
gppnhp
-
preganglionic
- drug development
-
wga-hrp
-
parabrachial
- medicine
- diagnostics
Reaction
Synonyms
(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-elongation factor 2, ADP-ribosyltransferase, cholera toxin, cholix, cholix toxin, chxA, CTB, diphthamide-specific ADPRT, diphthamide-specific mono-ADP-ribosylating toxin, EHI 155600, EhToxin-l, EhToxin-like, ExoA, ExoA(c), exotoxin A, mono(ADPribosyl)transferase, mono-ADP-ribosyltransferase, NAD(+)-diphthamide ADP-ribosyltransferase, NAD-diphthamide ADP-ribosyltransferase, NAD-diphthamide ADP-ribosyltransferase NAD-elongation factor 2 ADP-ribosyltransferase, NAD:elongation factor 2-adenosine diphosphate ribose-transferase
ECTree
2.4.2.36 NAD+-diphthamide ADP-ribosyltransferaseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 2.4.2.36 - NAD+-diphthamide ADP-ribosyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
NAD+ + diphthamide-[Escherichia coli elongation factor Tu]
nicotinamide + N-(ADP-D-ribosyl)diphthamide-[Escherichia coli elongation factor Tu]
-
-
-
?
NAD+ + diphthamide-[translation elongation factor 2]
nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
NAD+ + essential ribosomal elongation factor 2
nicotinamide + H+ + ADP-ribosylated essential ribosomal elongation factor 2
NAD+ + G-protein
?
-
NAD-dependent ADP-ribosylation of Arg201 of G-protein alpha-subunit, this locks the G-protein in its active state producing cAMP
-
-
?
NAD+ + peptide diphthamide
nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide
-
-
-
-
?
eEF2 + NAD+
eEF2 N-(ADP-D-ribosyl)diphthamide + NADH + H+
-
i.e. eukaryotic elongation factor 2, contains a post-translationally modified histidine residue, known as diphthamide, which is the specific ADP-ribosylation target of Pseudomonas aeruginosa exotoxin A
-
-
?
eEF2 + NAD+
eEF2 N-(ADP-D-ribosyl)diphthamide + NADH + H+
-
i.e. eukaryotic elongation factor 2 with a diphthamide-containing loop comprising residues Leu693-Gly703, ADP-ribosylation at His699, site determination by mass spectrometry and mutational analysis, overview
-
-
?
NAD+ + diphthamide-[translation elongation factor 2]
nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
-
-
-
-
?
NAD+ + diphthamide-[translation elongation factor 2]
nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
-
-
-
?
NAD+ + diphthamide-[translation elongation factor 2]
nicotinamide + N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]
-
-
-
?
NAD+ + elongation factor 2
nicotinamide + ADPribose-elongation factor 2
-
liver enzyme
-
?
NAD+ + elongation factor 2
nicotinamide + ADPribose-elongation factor 2
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i.e. elongation factor 2 of baby hamster kidney cells, forward ADP-ribosylation reaction is reversed by fragment A from Pseudomonas aeruginosa
-
r
NAD+ + elongation factor 2
nicotinamide + ADPribose-elongation factor 2
-
-
-
?
NAD+ + elongation factor 2
nicotinamide + ADPribose-elongation factor 2
-
-
-
r
NAD+ + elongation factor 2
nicotinamide + ADPribose-elongation factor 2
-
NAD-glycohydrolase activity without acceptor substrate
-
?
NAD+ + elongation factor 2
nicotinamide + ADPribose-elongation factor 2
-
reaction involves a random-order ternary complex
-
-
?
NAD+ + elongation factor 2
nicotinamide + ADPribose-elongation factor 2
-
-
-
-
?
NAD+ + essential ribosomal elongation factor 2
nicotinamide + H+ + ADP-ribosylated essential ribosomal elongation factor 2
transfer of ADP-ribose moiety (oxocarbenium ion) of NAD+ onto N3 of diphthamide imidazole of essential ribosomal elongation factor 2 (eEF2)
-
-
?
NAD+ + essential ribosomal elongation factor 2
nicotinamide + H+ + ADP-ribosylated essential ribosomal elongation factor 2
essential ribosomal elongation factor 2: eEF2, 2-step reaction by concerted GH and ADPRT activity, transition-state model
-
-
?
additional information
?
-
NAD+-dependent ADP-ribosyltransfer (ADPRT) including NAD+-glycohydrolysis (GH) activity, deadly virulent due to covalent modification and thus inactivation of proteins that are essential for the host
-
-
?
additional information
?
-
-
NAD+-dependent ADP-ribosyltransfer (ADPRT) including NAD+-glycohydrolysis (GH) activity, deadly virulent due to covalent modification and thus inactivation of proteins that are essential for the host
-
-
?
additional information
?
-
no ADP-ribosyl transfer by mutants R551H and R551C despite of occurring NAD+-binding and hydrolysis
-
-
?
additional information
?
-
-
no ADP-ribosyl transfer by mutants R551H and R551C despite of occurring NAD+-binding and hydrolysis
-
-
?
additional information
?
-
-
cholera toxin activates mouse bone marrow mast cells to release interleukin-4 via activation of nucleotide oligomerisation domain 1 and toll-like receptor-4, and initiation of antigen-specific T-helper 2 response
-
-
?
