2.4.2.36: NAD+-diphthamide ADP-ribosyltransferase

This is an abbreviated version!
For detailed information about NAD+-diphthamide ADP-ribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.36

2.4.2.36

camp

cyclase

vibrio

mucosal

pertussis

adp-ribosylation

adenylate

forskolin

retrograde

gm1

ganglioside

aeruginosa

enterotoxin

iga

agonist

tracer

dorsal

prostaglandin

heat-labile

intranasal

dibutyryl

afferent

isoproterenol

adenylyl

g-proteins

innervation

gtp-binding

diphtheria

immunotoxins

anterograde

b-subunits

rostrally

toxigenic

ribosylation

pilus

toxin-induced

toxin-sensitive

pyrogenic

toxoid

8-bromo-camp

diarrheal

antitoxin

ventrolateral

peyer

exoenzyme

enterotoxigenic

gppnhp

preganglionic

drug development

wga-hrp

parabrachial

medicine

diagnostics

Reaction

diphthamide-[translation elongation factor 2]

N-(ADP-D-ribosyl)diphthamide-[translation elongation factor 2]

Synonyms

(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-elongation factor 2, ADP-ribosyltransferase, cholera toxin, cholix, cholix toxin, chxA, CTB, diphthamide-specific ADPRT, diphthamide-specific mono-ADP-ribosylating toxin, EHI 155600, EhToxin-l, EhToxin-like, ExoA, ExoA(c), exotoxin A, mono(ADPribosyl)transferase, mono-ADP-ribosyltransferase, NAD(+)-diphthamide ADP-ribosyltransferase, NAD-diphthamide ADP-ribosyltransferase, NAD-diphthamide ADP-ribosyltransferase NAD-elongation factor 2 ADP-ribosyltransferase, NAD:elongation factor 2-adenosine diphosphate ribose-transferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.36 NAD+-diphthamide ADP-ribosyltransferase

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Results	in table
8	Activating Compound
41	AA Sequence
4	Application
1	CAS Registry Number
4	Cloned(Commentary)
1	Cofactor
4	Crystallization (Commentary)
2	General Information
9	IC50 Value
31	Inhibitors
8	Ki Value [mM]
41	KM Value [mM]
5	Localization
2	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
18	Organism
42	PDB ID
3	pH Optimum
1	Posttranslational Modification
45	Protein Variants
6	Purification (Commentary)
1	Reaction
2	Reaction Type
18	Reference
4	Source Tissue
21	Substrates and Products (Substrate)
5	Subunits
30	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
84	Turnover Number [1/s]

KI Value

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KI Value on EC 2.4.2.36 - NAD+-diphthamide ADP-ribosyltransferase

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0.03

3-((3,3-diisopropylguanidino)methyl)benzamide

Vibrio cholerae serotype O1

37°C, pH 7

696625

0.013

3-((3-(1-benzylpiperidin-4-yl)guanidino)methyl)benzamide

Vibrio cholerae serotype O1

37°C, pH 7

696625

0.008

3-((3-(4-bromobenzyl)guanidino)methyl)benzamide

Vibrio cholerae serotype O1

37°C, pH 7, 1400fold more potent than NAD+ and 400fold more potent than diethylamino(benzylidine-amino)guanidine

696625

0.05

3-((3-benzylguanidino)methyl)benzamide

Vibrio cholerae serotype O1

37°C, pH 7

696625

0.071

3-((3-phenethylguanidino)methyl)benzamide

Vibrio cholerae serotype O1

37°C, pH 7

696625

0.5

3-((3-tert-butylguanidino)methyl)benzamide

Vibrio cholerae serotype O1

37°C, pH 7

696625

0.09

3-(3,3-diisopropylguanidino)benzamide

Vibrio cholerae serotype O1

37°C, pH 7

696625

0.5

3-(3-phenylguanidino)benzamide

Vibrio cholerae serotype O1

37°C, pH 7

696625