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2.4.2.30: NAD+ ADP-ribosyltransferase

This is an abbreviated version!
For detailed information about NAD+ ADP-ribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.30

Reaction

NAD+
+
(ADP-D-ribosyl)n-acceptor
=
nicotinamide
 +
(ADP-D-ribosyl)n+1-acceptor
 +
H+

Synonyms

(adenosine diphosphoribose)transferase, nicotinamide adenine dinucleotide-protein, 193-kDa vault protein , 2,3,7,8-tetrachlorodibenzo-p-dioxin poly(ADP-ribose) polymerase, adenosine diphosphate ribosyltransferase, ADP-ribosylating thermozyme, ADP-ribosyltransferase, ADP-ribosyltransferase (polymerizing), ADP-ribosyltransferase 3, ADP-ribosyltransferase C3cer, ADP-ribosyltransferase-1, ADPr, ADPRT, ADPRT , ART, ART1, ARTC2.2, ARTD10, ARTD10/PARP10, ARTD11, ARTD14, ARTD3, ARTD7/PARP15, ARTD8, asparagine-specific ADP-ribosyltransferase, B aggressive lymphoma protein 2, C3 exoenzyme, C3-like toxin, C3larvin toxin, C3lim, CRM66, diphtheria toxin-like ADP-ribosyltranferase, ecto-ADP-ribosyltransferase, ecto-ADP-ribosyltransferase 2.2, ecto-ADP-ribosyltransferase ART2.2, EspJ, Exo53, exoenzyme C3, exoenzyme S, exoenzyme T, ExoS, ExoT, exotoxin-S, mART, ModA, ModB, mono ADP-ribosyltransferase, mono(ADP-ribosyl) transferase, mono-ADP-ribosyl transferase C3, mono-ADP-ribosyltransferase, More, msPARP , NAD(+) ADP-ribosyltransferase , NAD+:ADP-ribosyltransferase (polymerizing), NAD-dependent ADP-ribosyltransferase, NAD-protein ADP-ribosyltransferase, NarE, pADPRT, PAR polymerase, PARP, PARP , PARP-1, PARP-7, PARP-related/IalphaI-related H5/proline-rich , PARP1, PARP10, PARP11, PARP14, PARP3, PARPss, pertussis toxin, PH5P , poly (ADP-ribose) polymerase, poly (ADP-ribose) polymerase-1, poly(ADP-ribose) polymerase, poly(ADP-ribose) polymerase family member 11, poly(ADP-ribose) polymerase-1, poly(ADP-ribose) polymerase-11, poly(ADP-ribose) polymerase-like enzyme, poly(ADP-ribose) synthase, poly(ADP-ribose) transferase, poly(ADP-ribosyl)transferase, poly[ADP-ribose] synthetase , PTx, PtxS1, scabin, TANK1, TANK1 , TANK2 , tankyrase I, Tankyrase-like protein , Tankyrase-related protein , TbSIR2RP1, TiPARP, TNKS-1, TRF1-interacting ankyrin-related ADP-ribose polymerase, TRF1-interacting ankyrin-related ADP-ribose polymerase , TTS-ExoS, type III-secreted toxin, VahC, VPARP , vsdc, YART

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.30 NAD+ ADP-ribosyltransferase

Natural Substrates Products

Natural Substrates Products on EC 2.4.2.30 - NAD+ ADP-ribosyltransferase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
integrin alpha7 + NAD+
(ADP-D-ribosyl)-integrin alpha7 + nicotinamide
show the reaction diagram
-
the extracellular domain of integrin alpha7 is ADP-ribosylated by an arginine-specific ecto-ADP-ribosyltransferase after adding exogenous NAD+ to intact C2C12 muscle cells, integrin alpha7 N-terminal ADP-ribosylation inhibits the binding of integrin alpha7beta1 to laminin activation status of integrin alpha7beta1 in intact myotubes, overview
-
-
?
NAD+ + (ADP-D-ribosyl)n-acceptor
nicotinamide + (ADP-D-ribosyl)n+1-acceptor
show the reaction diagram
NAD+ + (ADP-D-ribosyl)n-acceptor
nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+
show the reaction diagram
NAD+ + (ADP-D-ribosyl)n-aryl hydrocarbon receptor
nicotinamide + (ADP-D-ribosyl)n+1-aryl hydrocarbon receptor + H+
show the reaction diagram
-
-
-
?
NAD+ + (ADP-D-ribosyl)n-beta-transducin repeat-containing protein
nicotinamide + (ADP-D-ribosyl)n+1-beta-transducin repeat-containing protein + H+
show the reaction diagram
-
-
-
-
?
NAD+ + (ADP-D-ribosyl)n-NEMO protein
nicotinamide + (ADP-D-ribosyl)n+1-NEMO protein + H+
show the reaction diagram
the enzyme prevents poly-ubiquitination of NEMO protein
-
-
?
NAD+ + (ADP-D-ribosyl)n-p21ras
nicotinamide + (ADP-D-ribosyl)n+1-p21ras
show the reaction diagram
-
ADP-ribosylation of p21ras does not alter interactions with guanidine nucleotides. Possible function of the enzyme in pathogenesis
-
-
?
NAD+ + (ADP-D-ribosyl)n-P2X7 ion channel
nicotinamide + (ADP-D-ribosyl)n+1-P2X7 ion channel + H+
show the reaction diagram
-
-
-
-
?
NAD+ + (ADP-D-ribosyl)n-rab4
nicotinamide + (ADP-D-ribosyl)n+1-rab4
show the reaction diagram
-
ADP-ribosylation affects Rab4 function in membrane recycling
-
-
?
NAD+ + (ADP-D-ribosyl)n-Rab5
nicotinamide + (ADP-D-ribosyl)n+1-Rab5
show the reaction diagram
-
ADP-ribosylation of Rab5 by ExoS affects endocytosis. Interaction of Rab5 with endosome antigen 1 is markedly diminished after Rab5 ADP-ribosylation by ExoS
-
-
?
NAD+ + (ADP-D-ribosyl)n-Rab5
nicotinamide + (ADP-D-ribosyl)n+1-Rab5 + H+
show the reaction diagram
-
the enzyme ADP-ribosylates Rab5 at Gln79
-
-
?
NAD+ + (ADP-D-ribosyl)n-RalA
nicotinamide + (ADP-D-ribosyl)n+1-RalA
show the reaction diagram
-
ADP-ribosylation of RalA by ExoS interferes with RalA activation and binding to its downstream effector in J774A.1 macrophages and suggests the potential of ExoS ADPRT activity to interfere with filiopodium formation through the inactivation of RalA and downstream effects mediated through the exocyst complex
-
-
?
NAD+ + (ADP-D-ribosyl)n-Ras
nicotinamide + (ADP-D-ribosyl)n+1-Ras
show the reaction diagram
-
ADP-ribosylation of Ras at Arg41 disrupts Ras-Cdc25 interactions, which inhibits the rate-limiting step in Ras signal transduction, the activation of Ras by its guanine nucleotide exchange factor
-
-
?
NAD+ + (ADP-D-ribosyl)n-RhoA protein
nicotinamide + (ADP-D-ribosyl)n+1-RhoA protein + H+
show the reaction diagram
NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Btk
nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Btk + H+
show the reaction diagram
-
-
-
-
?
NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Csk
nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Csk + H+
show the reaction diagram
-
-
-
-
?
NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Hck
nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Hck + H+
show the reaction diagram
-
-
-
-
?
NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Lyn
nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Lyn + H+
show the reaction diagram
-
-
-
-
?
NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Src
nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Src + H+
show the reaction diagram
-
-
-
-
?
NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Syk
nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Syk + H+
show the reaction diagram
-
-
-
-
?
NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Tec
nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Tec + H+
show the reaction diagram
-
-
-
-
?
NAD+ + (ADP-D-ribosyl)n-tyrosine kinase Yes1
nicotinamide + (ADP-D-ribosyl)n+1-tyrosine kinase Yes1 + H+
show the reaction diagram
-
-
-
-
?
NAD+ + cyclophilin A
nicotinamide + (ADP-D-ribosyl)-cyclophilin A
show the reaction diagram
NAD+ + Galphai
nicotinamide + (ADP-D-ribosyl)-Galphai + H+
show the reaction diagram
NAD+ + histone H2A
nicotinamide + (ADP-D-ribosyl)-histone H2A
show the reaction diagram
-
the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair
-
-
?
NAD+ + histone H2B
nicotinamide + (ADP-D-ribosyl)-histone H2B
show the reaction diagram
-
the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair
-
-
?
NAD+ + moesin
nicotinamide + (ADP-D-ribosyl)-moesin
show the reaction diagram
-
ADP-ribosylated-moesin is a poor target for phosphorylation by protein kinase C and Rho kinase, which shows that ADP-ribosylation directly inhibits ERM phosphorylation
-
-
?
NAD+ + p53
nicotinamide + (ADP-D-ribosyl)-p53
show the reaction diagram
-
-
-
-
?
NAD+ + Rab31
nicotinamide + (ADP-D-ribosyl)-Rab31 + H+
show the reaction diagram
-
the enzyme ADP-ribosylates Rab31 at Gln64
-
-
?
NAD+ + Rab5 protein
nicotinamide + (ADP-D-ribosyl)-Rab5 protein + H+
show the reaction diagram
NAD+ + Rab9 protein
nicotinamide + (ADP-D-ribosyl)-Rab9 protein + H+
show the reaction diagram
NAD+ + Ras
nicotinamide + (ADP-D-ribosyl)-Ras
show the reaction diagram
-
interaction requires residue Leu428
-
-
?
NAD+ + Ras GTPase
nicotinamide + (ADP-D-ribosyl)-Ras GTPase
show the reaction diagram
-
-
-
-
?
NAD+ + RNA polymerase
nicotinamide + (ADP-D-ribosyl)-RNA polymerase
show the reaction diagram
NAD+ + topoisomerase I
nicotinamide + (ADP-D-ribosyl)-topoisomerase I
show the reaction diagram
-
-
-
-
?
NAD+ + vimentin
nicotinamide + (ADP-D-ribosyl)-vimentin
show the reaction diagram
-
-
-
-
?
additional information
?
-