2.4.2.26: protein xylosyltransferase

This is an abbreviated version!
For detailed information about protein xylosyltransferase, go to the full flat file.

Reaction

Synonyms

LARGE, More, peptide O-xylosyltransferase, peptide O-xylosyltransferase 1, peptide-O-xylosyltransferase, Rumi, squashed vulva protein 6, SQV-6, UDP-alpha-D-xyloase:proteoglycan core protein beta-D-xylosyltransferase, UDP-alpha-D-xylose:proteoglycan core protein beta-D-xylosyltransferase, UDP-D-xylose:core protein beta-D-xylosyltransferase, UDP-D-xylose:core protein xylosyltransferase, UDP-D-xylose:proteoglycan core protein b-d-xylosyltransferase, UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase, UDP-xylose-core protein beta-D-xylosyltransferase, uridine diphosphoxylose-core protein beta-xylosyltransferase, uridine diphosphoxylose-protein xylosyltransferase, XT, XT-I, XT-II, xylosyltransferase, xylosyltransferase 1, xylosyltransferase 2, xylosyltransferase I, xylosyltransferase II, xylosyltransferase sqv-6, xylosyltransferase, uridine diphosphoxylose-core protein beta-, xylosyltransferase-I, xylosyltransferases II, XylT-I, XylT-II, XYLT1, XYLT2

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.26 protein xylosyltransferase

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Results	in table
8	Activating Compound
2945	AA Sequence
10	Application
1	CAS Registry Number
23	Cloned(Commentary)
109	Disease/ Diagnostics
8	Expression
7	General Information
30	Inhibitors
2	kcat/KM [mM/s]
19	Ki Value [mM]
178	KM Value [mM]
15	Localization
9	Metals/Ions
17	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
62	Organism
6	Pathway
15	PDB ID
12	pH Optimum
3	pH Range
2	Posttranslational Modification
37	Protein Variants
15	Purification (Commentary)
4	Reaction
1	Reaction Type
57	Reference
154	Source Tissue
11	Specific Activity [micromol/min/mg]
4	Storage Stability
201	Substrates and Products (Substrate)
9	Subunits
114	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
3	Temperature Range [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

KM Value

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KM Value on EC 2.4.2.26 - protein xylosyltransferase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0188

Aggrecan

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0179 - 0.0222

bamcan

2 entries

-

0.0208

betaglycan-1

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0093 - 0.0137

bFGF-peptide

2 entries

-

0.0097

biglycan

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0006 - 0.0656

bikunin

70 entries

-

0.022

bikunin-derived aminoterminus homologous peptide

Homo sapiens

-

-

637616

-

0.0019

Bio-QEEEGSGGGQKK-F

Homo sapiens

Q9H1B5

-

684886

0.0025 - 0.0061

biotin-NH-QEEEGSGGGQKK(5-fluorescein)-CONH2

3 entries

0.0052

biotin-NHQEEEGSGGGQKK(5-fluorescein)-CONH2

Homo sapiens

Q9H1B5

recombinant enzyme

680872

0.11 - 0.19

cartilage chondroitin sulfate proteoglycan

3 entries

-

0.0146

CD44

Homo sapiens

-

isoenzyme XT-I

702090

-

0.062

CDEASGIGPDDRD

Rattus norvegicus

-

-

637614

0.062

CDEASGIGPEVPDDRD

Rattus norvegicus

-

-

637614

0.0034

collagen alpha2(IX)

Homo sapiens

-

isoenzyme XT-I

702090

-

0.5

DDDSIEGSGGR

Drosophila sp. (in: flies)

-

-

659174

0.037

decorin (PG40) peptide

Rattus norvegicus

-

-

660394

-

0.062

fibroblast growth factor 2

Homo sapiens

Q9H1B5

recombinant enzyme

680872

-

0.0191

fibroblast growth factor 2 fragment 1-24

Homo sapiens

Q9H1B5

-

684886

-

0.12

FMLEDEASGIGP

Rattus norvegicus

-

-

637614

0.0208 - 0.0223

fragment(1-24) of human basic fibroblast growth factor

2 entries

-

8.5

Gln-Ser-Gly

Gallus gallus

-

-

658761

28

Gly-Ser-Gly

Gallus gallus

-

-

658761

0.04

Gly-Ser-Gly-Ser-Gly-Ser-Gly-Ser-Gly-Ser

Gallus gallus

-

0.2 mM in terms of Ser

658761

87

Gly-Thr-Gly

Gallus gallus

-

-

658761

0.0109 - 0.0171

glypican-1

2 entries

-

2.67

GVEGSADFLK

Homo sapiens

-

-

637615

0.00011 - 1.02

HF-degraded chondroitin sulfate proteoglycan

3 entries

-

0.0572

human basic fibroblast growth factor

Homo sapiens

-

native XT-I

657789

-

8.27

KKDSGPY

Homo sapiens

-

-

637615

3.625

KTKGSGFFVF

Homo sapiens

-

-

637615

0.0104 - 0.0134

L-APLP2

2 entries

0.0131

L-APP

Homo sapiens

-

XT-I

702090

0.0032 - 0.0236

neuroglycan C

2 entries

-

0.13

NFDEIDRSGFGFN

Homo sapiens

-

-

637615

0.0133

perlecan-1

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0102 - 0.0145

perlecan-2

2 entries

-

0.0094 - 0.0187

perlecan-3

2 entries

-

0.0166

phosphacan

Homo sapiens

-

isoenzyme XT-I

702090

-

0.39

PLVSSGEDEPK

Homo sapiens

-

-

637615

0.022

QEEEGSGGGOK

Homo sapiens

-

-

637615

0.008

QEEEGSGGGQGG

Rattus norvegicus

-

-

637617, 658421

0.022

QEEEGSGGGQK

Homo sapiens

-

-

637616

0.01172 - 0.093

QEEEGSGGGQKK

3 entries

0.82

QEEEGTGGGQGG

Rattus norvegicus

-

-

658421

8.6

QGGGGSGGGQGG

Rattus norvegicus

-

-

658421

0.26

rat L2 chondroitin sulfate

Rattus norvegicus

-

-

660394

-

1.39

SAAYSGSGSG

Rattus norvegicus

-

-

660394

0.79

SDDYSGSGSG

Rattus norvegicus

-

-

637614

0.019

SENEGSGMAEQK

Homo sapiens

-

-

637616

0.019

SENEGSGMAQQK

Homo sapiens

-

-

637616

20 - 55

Ser-Gly-Gly

2 entries

0.0023 - 0.0111

serglycin

2 entries

-

0.545 - 0.677

silk fibroin

4 entries

-

0.064 - 0.18

Smith-degraded chondroitin sulfate proteoglycan

2 entries

-

0.0122 - 0.0178

syndecan

2 entries

-

0.0074 - 0.0198

syndecan-1

2 entries

-

0.0035 - 0.0141

syndecan-4

2 entries

-

0.02 - 0.3905

TENEGSGLTNIK

3 entries

0.0082 - 0.0103

testican-2

2 entries

-

0.0029 - 0.0182

Thrombomodulin

2 entries

-

0.0065 - 0.25

UDP-D-xylose

8 entries

0.0065

UDP-xylose

Rattus norvegicus

-

cosubstrate: QEEEGSGGGQGG

658421

0.94

VCRSGSGLVGK

Homo sapiens

-

-

637615

0.0127 - 0.0146

versican-beta

2 entries

-

0.42

WAGGDASGE

Homo sapiens

-

-

637615

0.155

[Smith-degraded chondroitin sulfate proteoglycan]-L-serine

Gallus gallus

-

-

658463

-

0.0008

[Val36,Val38]delta1[Gly92,Ile94]delta2bikunin

Homo sapiens

-

-

657758

additional information

additional information

2 entries

-

0.0179

bamcan

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0222

bamcan

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0093

bFGF-peptide

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0137

bFGF-peptide

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0006

bikunin

Homo sapiens

-

recombinant mutant bikunin

637615, 637616

-

0.0009

bikunin

Gallus gallus

-

-

658463

-

0.0009

bikunin

Homo sapiens

-

recombinant wild-type bikunin

637615

-

0.0009

bikunin

Homo sapiens

-

37°C, pH 6.5

678024

-

0.0009

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, wild-type enzyme

659394

-

0.0009

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme D316G

659394

-

0.0009

bikunin

Homo sapiens

-

37°C, pH 6.5, mutant enzyme DELTA1-184

678024

-

0.001

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, wild-type enzyme

657858

-

0.001

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme C933A

657858

-

0.0011

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme D314G

659394

-

0.0011

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme D745E

659394

-

0.0011

bikunin

Homo sapiens

-

37°C, pH 6.5, mutant enzyme K262A

678024

-

0.0011

bikunin

Homo sapiens

-

37°C, pH 6.5, mutant enzyme R270A

678024

-

0.0012

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme C920A

657858

-

0.0012

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme W746D

659394

-

0.0012

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme W746G

659394

-

0.0012

bikunin

Homo sapiens

-

37°C, pH 6.5, mutant enzyme S269A

678024

-

0.0013

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme W746N

659394

-

0.0013

bikunin

Homo sapiens

-

37°C, pH 6.5, mutant enzyme E263A

678024

-

0.0013

bikunin

Homo sapiens

-

37°C, pH 6.5, mutant enzyme K272A

678024

-

0.0013

bikunin

Homo sapiens

-

37°C, pH 6.5, mutant enzyme S266A

678024

-

0.0014

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme C301A

657858

-

0.0014

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme C675A

657858

-

0.0014

bikunin

Homo sapiens

-

37°C, pH 6.5, mutant enzyme DELTA1-213

678024

-

0.0014

bikunin

Homo sapiens

-

37°C, pH 6.5, mutant enzyme DELTA1-260

678024

-

0.0016

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme C542A

657858

-

0.002

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme C927A

657858

-

0.0028

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme C285A

657858

-

0.0044

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme D747E

659394

-

0.005

bikunin

Homo sapiens

-

37°C, pH 6.5, mutant enzyme DELTA1-266

678024

-

0.0053

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme C257A

657858

-

0.0054

bikunin

Homo sapiens

-

37°C, pH 6.5, mutant enzyme DELTA1-272

678024

-

0.0064

bikunin

Homo sapiens

-

isoenzyme XT-II with mutant bikunin (sequence QEE-GSGRGQLV)

702090

-

0.0069

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme D747G

659394

-

0.0077

bikunin

Homo sapiens

-

isoenzyme XT-II with mutant bikunin (sequence QEEEGSGHNMLV)

702090

-

0.0085

bikunin

Homo sapiens

-

isoenzyme XT-II with mutant bikunin (sequence QEEESSGGGQLV)

702090

-

0.0093

bikunin

Homo sapiens

-

isoenzyme XT-II with mutant bikunin (sequence QEEEGSGSLALV)

702090

-

0.0099

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEERSGGGQLV)

702090

-

0.0103

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEESSGGGQLV)

702090

-

0.0108

bikunin

Homo sapiens

Q9H1B5

-

684886

-

0.0119

bikunin

Homo sapiens

Q86Y38

pH 6.5, 37°C, mutant enzyme C563A

657858

-

0.0123

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEE-GSGGGQLV)

702090

-

0.0125

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEEGSGHNMLV)

702090

-

0.0133

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEEGSSCGQLV)

702090

-

0.0137

bikunin

Homo sapiens

-

isoenzyme XT-II with mutant bikunin (sequence QEEEGSGRRALV)

702090

-

0.015

bikunin

Homo sapiens

-

isoenzyme XT-II with mutant bikunin (sequence QEEEGSGGRSVLV)

702090

-

0.0151

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEEGSGCGQLV)

702090

-

0.0153

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEEGSSGGQLV)

702090

-

0.0199

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEEGSGSLALV)

702090

-

0.02

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QKEEGSGGGQLV)

702090

-

0.0205

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEE-GSGRGQLV)

702090

-

0.0215

bikunin

Homo sapiens

-

isoenzyme XT-II with mutant bikunin (sequence QEEEGSGCYKLV)

702090

-

0.022

bikunin

Homo sapiens

Q9H1B5

-

680872

-

0.022

bikunin

Homo sapiens

Q9H1B5

recombinant enzyme

680872

-

0.0227

bikunin

Homo sapiens

-

isoenzyme XT-II with mutant bikunin (sequence QEEEGSGCGQLV)

702090

-

0.0242

bikunin

Homo sapiens

-

isoenzyme XT-II with mutant bikunin (sequence QEEEGSGRHLLV)

702090

-

0.0243

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEESSGRGQLV)

702090

-

0.0251

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEEGSGGRSVLV)

702090

-

0.0274

bikunin

Homo sapiens

-

isoenzyme XT-I with wild-type bikunin (sequence QEEEGSGGGQLV)

702090

-

0.0288

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEEGSTSLV)

702090

-

0.0301

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEEGSGCYKLV)

702090

-

0.0318

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QLTTGSGGGQLV)

702090

-

0.0356

bikunin

Homo sapiens

-

isoenzyme XT-II with mutant bikunin (sequence QKEEGSGGGQLV)

702090

-

0.0462

bikunin

Homo sapiens

-

isoenzyme XT-II with wild-type bikunin (sequence QEEEGSGGGQLV)

702090

-

0.0463

bikunin

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0508

bikunin

Homo sapiens

-

isoenzyme XT-II with mutant bikunin (sequence QEEEGSGCRVLV)

702090

-

0.0543

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEEGSGCRVLV)

702090

-

0.0572

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEEGSGRHLLV)

702090

-

0.0586

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QEEEGSGRRALV)

702090

-

0.0656

bikunin

Homo sapiens

-

isoenzyme XT-I with mutant bikunin (sequence QPQIGSGGGQLV)

702090

-

0.0025

biotin-NH-QEEEGSGGGQKK(5-fluorescein)-CONH2

Homo sapiens

-

XylT-I

702029

0.0052

biotin-NH-QEEEGSGGGQKK(5-fluorescein)-CONH2

Homo sapiens

Q9H1B5

-

680872

0.0061

biotin-NH-QEEEGSGGGQKK(5-fluorescein)-CONH2

Homo sapiens

-

XylT-II

702029

0.11

cartilage chondroitin sulfate proteoglycan

Rattus norvegicus

-

-

637614

-

0.155

cartilage chondroitin sulfate proteoglycan

Homo sapiens

-

trifluoromethanesulfonic acid-degraded substrate

637615

-

0.19

cartilage chondroitin sulfate proteoglycan

Homo sapiens

-

hydrogen fluoride-degraded substrate

637615

-

0.0208

fragment(1-24) of human basic fibroblast growth factor

Homo sapiens

-

native XT-I

657789

-

0.0223

fragment(1-24) of human basic fibroblast growth factor

Homo sapiens

-

recombinant XT-I

657789

-

0.0109

glypican-1

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0171

glypican-1

Homo sapiens

-

isoenzyme XT-I

702090

-

0.00011

HF-degraded chondroitin sulfate proteoglycan

Rattus norvegicus

-

-

637614

-

0.0029

HF-degraded chondroitin sulfate proteoglycan

Rattus norvegicus

-

-

660394

-

1.02

HF-degraded chondroitin sulfate proteoglycan

Gallus gallus

-

-

658761

-

0.0104

L-APLP2

Homo sapiens

-

isoenzyme XT-II

702090

0.0134

L-APLP2

Homo sapiens

-

isoenzyme XT-I

702090

0.0032

neuroglycan C

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0236

neuroglycan C

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0102

perlecan-2

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0145

perlecan-2

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0094

perlecan-3

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0187

perlecan-3

Homo sapiens

-

isoenzyme XT-I

702090

-

0.01172

QEEEGSGGGQKK

Mus musculus

-

in Xylt2

703904

0.02048

QEEEGSGGGQKK

Mus musculus

-

in Xylt1

703904

0.093

QEEEGSGGGQKK

Rattus norvegicus

-

-

637617

20

Ser-Gly-Gly

Gallus gallus

-

-

659112

55

Ser-Gly-Gly

Gallus gallus

-

-

658761

0.0023

serglycin

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0111

serglycin

Homo sapiens

-

isoenzyme XT-I

702090

-

0.545

silk fibroin

Gallus gallus

-

-

658463

-

0.545

silk fibroin

Homo sapiens

-

-

637615

-

0.677

silk fibroin

Homo sapiens

Q9H1B5

-

680872

-

0.677

silk fibroin

Homo sapiens

Q9H1B5

recombinant enzyme

680872

-

0.064

Smith-degraded chondroitin sulfate proteoglycan

Gallus gallus

-

-

659112

-

0.18

Smith-degraded chondroitin sulfate proteoglycan

Gallus gallus

-

-

658761

-

0.0122

syndecan

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0178

syndecan

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0074

syndecan-1

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0198

syndecan-1

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0035

syndecan-4

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0141

syndecan-4

Homo sapiens

-

isoenzyme XT-II

702090

-

0.02

TENEGSGLTNIK

Homo sapiens

-

-

637616

0.2132

TENEGSGLTNIK

Mus musculus

-

in Xylt1

703904

0.3905

TENEGSGLTNIK

Mus musculus

-

in Xylt2

703904

0.0082

testican-2

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0103

testican-2

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0029

Thrombomodulin

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0182

Thrombomodulin

Homo sapiens

-

isoenzyme XT-I

702090

-

0.0065

UDP-D-xylose

Rattus norvegicus

-

-

637617

0.01

UDP-D-xylose

Rattus norvegicus

-

cosubstrate: Smith-degraded chondroitin sulfate

657633

0.019

UDP-D-xylose

Gallus gallus

-

Smith-degraded proteoglycan, value on serine basis

637613

0.025

UDP-D-xylose

Gallus gallus

-

-

637610

0.1

UDP-D-xylose

Drosophila sp. (in: flies)

-

cosubstrate: DDDSIEGSGGR

659174

0.18

UDP-D-xylose

Rattus norvegicus

-

-

637614

0.18

UDP-D-xylose

Rattus norvegicus

-

cosubstrate: CDEASGIGPDDRD

637614

0.25

UDP-D-xylose

Homo sapiens

Q86Y38, Q9H1B5

about

680877

0.0127

versican-beta

Homo sapiens

-

isoenzyme XT-II

702090

-

0.0146

versican-beta

Homo sapiens

-

isoenzyme XT-I

702090

-

additional information

additional information

Rattus norvegicus

-

-

637614

-

additional information

additional information

Rattus norvegicus

-

-

637617

-