2.4.2.21: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase

This is an abbreviated version!
For detailed information about nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase, go to the full flat file.

Reaction

Synonyms

5,6-dimethylbenzimidazole phosphoribosyltransferase, ArsAB, CblT, CobT, CobT2, N(1)-alpha-phosphoribosyltransferase, N1-alpha-phosphoribosyltransferase, NaMN:DMB phosphoribosyltransferase, nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase, nicotinate mononucleotide:5,6-dimethylbenzimidazolyl phosphoribosyltransferase, nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase, NN:DBI PRT, phosphoribosyltransferase, nicotinate mononucleotide-dimethylbenzimidazole, SoArsAB

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.21 nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase

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Results	in table
21111	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
5	Crystallization (Commentary)
8	kcat/KM [mM/s]
19	KM Value [mM]
1	Metals/Ions
5	Molecular Weight [Da]
7	Natural Substrates/ Products (Substrates)
24	Organism
14	Pathway
50	PDB ID
7	pH Optimum
1	pH Range
13	Protein Variants
5	Purification (Commentary)
4	Reaction
1	Reaction Type
22	Reference
21	Specific Activity [micromol/min/mg]
2	Storage Stability
70	Substrates and Products (Substrate)
6	Subunits
24	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
10	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.4.2.21 - nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

5,6-dimethylbenzimidazole + beta-nicotinate D-ribonucleotide

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole

2 entries

beta-nicotinate D-ribonucleotide + 5(6)-nitrobenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5(6)-nitrobenzimidazole

Acetoanaerobium sticklandii

-

-

489777

-

-

?

beta-nicotinate D-ribonucleotide + 5,6-dichlorobenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dichlorobenzimidazole

Acetoanaerobium sticklandii

-

-

489777

-

-

?

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + alpha-ribazole 5'-phosphate

6 entries

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole

6 entries

beta-nicotinate D-ribonucleotide + 5-hydroxybenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5-hydroxybenzimidazole

3 entries

beta-nicotinate D-ribonucleotide + 5-methoxybenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5-methoxybenzimidazole

3 entries

beta-nicotinate D-ribonucleotide + 5-methylbenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5-methylbenzimidazole

3 entries

beta-nicotinate D-ribonucleotide + benzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-benzimidazole

3 entries

NAD+ + 5,6-dimethylbenzimidazole

nicotinamide + alpha-5,6-dimethylbenzimidazole adenine dinucleotide

2 entries

nicotinamide nucleoside + benzimidazole

?

Propionibacterium freudenreichii subsp. shermanii

-

-

489776

-

-

ir

nicotinic acid mononucleotide + 4,5-dimethyl-1,2-phenylenediamine

nicotinate + ?

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

489780

-

-

?

nicotinic acid mononucleotide + adenine

7-alpha-D-ribofuranosyladenine 5'-phosphate + nicotinate

2 entries

nicotinic acid mononucleotide + adenine

nicotinate + ?

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

489780

-

-

?

nicotinic acid mononucleotide + benzimidazole

1-alpha-D-ribofuranosylbenzimidazole 5'-phosphate + nicotinate

5 entries

nicotinic acid mononucleotide + benzimidazole

1-alpha-D-ribofuranosylbenzimidazole 5'-phosphate + nicotinic acid

Salmonella enterica

-

-

489781

alpha-ribazole 5'-phosphate, intermediate for the lower ligand of cobalamin

489781

?

nicotinic acid mononucleotide + benzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-benzimidazole

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

489780

-

-

?

nicotinic acid mononucleotide + guanine

nicotinate + ?

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

489780

-

-

?

nicotinic acid mononucleotide + histidine

nicotinate + ?

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

489780

-

-

?

nicotinic acid mononucleotide + imidazole

nicotinate + ?

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

489780

-

-

?

nicotinic acid nucleoside + benzimidazole

?

Propionibacterium freudenreichii subsp. shermanii

-

-

489776

-

-

ir

NMN + 5,6-dimethylbenzimidazole

nicotinamide + ?

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

662777

-

-

?

NMN + benzimidazole

?

Propionibacterium freudenreichii subsp. shermanii

-

-

489776

-

-

ir

p-cresol + beta-nicotinate D-ribonucleotide

nicotinate + 4-hydroxyphenyl alpha-D-ribose 5-phosphate

2 entries

phenol + beta-nicotinate D-ribonucleotide

nicotinate + phenyl alpha-D-ribose 5-phosphate

2 entries

additional information

?

-

5 entries

5,6-dimethylbenzimidazole + beta-nicotinate D-ribonucleotide

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole

Sporomusa ovata

F6MZ55; F6MZ56

-

721677, 723215

-

-

?

5,6-dimethylbenzimidazole + beta-nicotinate D-ribonucleotide

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole

Sporomusa ovata

-

-

723215

-

-

?

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + alpha-ribazole 5'-phosphate

Geobacillus kaustophilus

-

-

759786

-

-

?

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + alpha-ribazole 5'-phosphate

Propionibacterium freudenreichii

D7GJ95

-

736750

-

-

?

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + alpha-ribazole 5'-phosphate

Propionibacterium freudenreichii DSM 4902

D7GJ95

-

736750

-

-

?

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + alpha-ribazole 5'-phosphate

Salmonella enterica

-

-

735682, 735924, 759786

-

-

?

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + alpha-ribazole 5'-phosphate

Salmonella enterica LT2

-

-

735682

-

-

?

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + alpha-ribazole 5'-phosphate

Sinorhizobium meliloti

-

-

735682, 735924

-

-

?

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole

Acetoanaerobium sticklandii

-

-

489777, 489778

-

-

?

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole

Propionibacterium freudenreichii subsp. shermanii

-

-

489776

-

489776

ir

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole

Pseudomonas denitrificans (nom. rej.)

P29935

-

489779

-

-

?

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole

Salmonella enterica

Q05603

-

704323

-

-

?

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

489780

-

489780

?

beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

662777

-

-

?

beta-nicotinate D-ribonucleotide + 5-hydroxybenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5-hydroxybenzimidazole

Salmonella enterica

-

-

735682, 735924

-

-

?

beta-nicotinate D-ribonucleotide + 5-hydroxybenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5-hydroxybenzimidazole

Salmonella enterica LT2

-

-

735682

-

-

?

beta-nicotinate D-ribonucleotide + 5-hydroxybenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5-hydroxybenzimidazole

Sinorhizobium meliloti

-

-

735682, 735924

-

-

?

beta-nicotinate D-ribonucleotide + 5-methoxybenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5-methoxybenzimidazole

Salmonella enterica

-

-

735682, 735924

-

-

?

beta-nicotinate D-ribonucleotide + 5-methoxybenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5-methoxybenzimidazole

Salmonella enterica LT2

-

-

735682

-

-

?

beta-nicotinate D-ribonucleotide + 5-methoxybenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5-methoxybenzimidazole

Sinorhizobium meliloti

-

-

735682, 735924

-

-

?

beta-nicotinate D-ribonucleotide + 5-methylbenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5-methylbenzimidazole

Salmonella enterica

-

-

735682, 735924

-

-

?

beta-nicotinate D-ribonucleotide + 5-methylbenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5-methylbenzimidazole

Salmonella enterica LT2

-

-

735682

-

-

?

beta-nicotinate D-ribonucleotide + 5-methylbenzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5-methylbenzimidazole

Sinorhizobium meliloti

-

-

735682, 735924

-

-

?

beta-nicotinate D-ribonucleotide + benzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-benzimidazole

Salmonella enterica

-

-

735682, 735924

-

-

?

beta-nicotinate D-ribonucleotide + benzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-benzimidazole

Salmonella enterica LT2

-

-

735682

-

-

?

beta-nicotinate D-ribonucleotide + benzimidazole

nicotinate + N1-(5-phospho-alpha-D-ribosyl)-benzimidazole

Sinorhizobium meliloti

-

-

735682, 735924

-

-

?

NAD+ + 5,6-dimethylbenzimidazole

nicotinamide + alpha-5,6-dimethylbenzimidazole adenine dinucleotide

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

662777

alpha-5,6-dimethylbenzimidazole adenine dinucleotide product identification by mass spectrometry

-

?

NAD+ + 5,6-dimethylbenzimidazole

nicotinamide + alpha-5,6-dimethylbenzimidazole adenine dinucleotide

Salmonella enterica subsp. enterica serovar Typhimurium

-

step in the biosynthesis of coenzyme B12, nuceotide loop assembly NLA pathway overview

662777

-

-

?

nicotinic acid mononucleotide + adenine

7-alpha-D-ribofuranosyladenine 5'-phosphate + nicotinate

Acetoanaerobium sticklandii

-

-

489777

-

489777

?

nicotinic acid mononucleotide + adenine

7-alpha-D-ribofuranosyladenine 5'-phosphate + nicotinate

Acetoanaerobium sticklandii

-

-

489778

-

489778

?

nicotinic acid mononucleotide + benzimidazole

1-alpha-D-ribofuranosylbenzimidazole 5'-phosphate + nicotinate

Acetoanaerobium sticklandii

-

highly specific for nicotinic acid mononucleotide

489777

-

489777

?

nicotinic acid mononucleotide + benzimidazole

1-alpha-D-ribofuranosylbenzimidazole 5'-phosphate + nicotinate

Propionibacterium freudenreichii subsp. shermanii

-

best substrate

489776

-

489776

ir

nicotinic acid mononucleotide + benzimidazole

1-alpha-D-ribofuranosylbenzimidazole 5'-phosphate + nicotinate

Pseudomonas denitrificans (nom. rej.)

P29935

-

489779

alpha-ribazole 5'-phosphate

489779

?

nicotinic acid mononucleotide + benzimidazole

1-alpha-D-ribofuranosylbenzimidazole 5'-phosphate + nicotinate

Salmonella enterica

-

-

489781

-

-

?

nicotinic acid mononucleotide + benzimidazole

1-alpha-D-ribofuranosylbenzimidazole 5'-phosphate + nicotinate

Salmonella enterica subsp. enterica serovar Typhimurium

-

-

489780

-

-

?

p-cresol + beta-nicotinate D-ribonucleotide

nicotinate + 4-hydroxyphenyl alpha-D-ribose 5-phosphate

Sporomusa ovata

F6MZ55; F6MZ56

-

721677, 723215

-

-

?

p-cresol + beta-nicotinate D-ribonucleotide

nicotinate + 4-hydroxyphenyl alpha-D-ribose 5-phosphate

Sporomusa ovata

-

-

723215

-

-

?

phenol + beta-nicotinate D-ribonucleotide

nicotinate + phenyl alpha-D-ribose 5-phosphate

Sporomusa ovata

F6MZ55; F6MZ56

-

721677, 723215

-

-

?

phenol + beta-nicotinate D-ribonucleotide

nicotinate + phenyl alpha-D-ribose 5-phosphate

Sporomusa ovata

-

-

723215

-

-

?

additional information

?

-

Propionibacterium freudenreichii subsp. shermanii

-

not substrate: NAD, ribose 1-phosphate, ribose 5-phosphate, 2-methylbenzimidazole

489776

-

-

?

additional information

?

-

Salmonella enterica

-

no activity with adenine, phenol, and p-cresol

735924

-

-

?

additional information

?

-

Salmonella enterica subsp. enterica serovar Typhimurium

-

substrate specificity

662777

-

-

?

additional information

?

-

Sinorhizobium meliloti

-

no activity with adenine, phenol, and p-cresol

735924

-

-

?

additional information

?

-

Sporomusa ovata

F6MZ55; F6MZ56

phloroglucinol is identified from an additive screen as a compound that dramatically improves the size, stability, and diffraction properties of the crystals. Subsequent structural studies show that phloroglucinol binds in the active site of ArsA

721677

-

-

?