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2.4.2.2: pyrimidine-nucleoside phosphorylase

This is an abbreviated version!
For detailed information about pyrimidine-nucleoside phosphorylase, go to the full flat file.

Word Map on EC 2.4.2.2

Reaction

2'-deoxyuridine
+
phosphate
=
Uracil
+
2-deoxy-alpha-D-ribose 1-phosphate

Synonyms

AmPyNP, BbPyNP, BfPyNP, BsPyNP, deoA, EC 2.4.2.23, GsPyNP, GtPyNP, LpPyNP, nucleoside phosphorylase, PDP, phosphorylase, pyrimidine nucleoside, Py-NPase, PYNP, pynpase, pyrimidine nucleoside phosphorylase, pyrimidine ribonucleoside phosphorylase, pyrimidine-nucleoside phosphorylase, pyrimidine/purine nucleoside phosphorylase, TTHA1771, TtPyNP, udp, UPase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.2 pyrimidine-nucleoside phosphorylase

Systematic Name

Systematic Name on EC 2.4.2.2 - pyrimidine-nucleoside phosphorylase

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SYSTEMATIC NAME
IUBMB Comments
pyrimidine-nucleoside:phosphate (2'-deoxy)-alpha-D-ribosyltransferase
Unlike EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidine phosphorylase, this enzyme can accept both the ribonucleosides uridine and cytidine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine [3,6]. The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction.