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2.4.2.2: pyrimidine-nucleoside phosphorylase

This is an abbreviated version!
For detailed information about pyrimidine-nucleoside phosphorylase, go to the full flat file.

Word Map on EC 2.4.2.2

Reaction

2'-deoxyuridine
+
phosphate
=
Uracil
+
2-deoxy-alpha-D-ribose 1-phosphate

Synonyms

AmPyNP, BbPyNP, BfPyNP, BsPyNP, deoA, EC 2.4.2.23, GsPyNP, GtPyNP, LpPyNP, nucleoside phosphorylase, PDP, phosphorylase, pyrimidine nucleoside, Py-NPase, PYNP, pynpase, pyrimidine nucleoside phosphorylase, pyrimidine ribonucleoside phosphorylase, pyrimidine-nucleoside phosphorylase, pyrimidine/purine nucleoside phosphorylase, TTHA1771, TtPyNP, udp, UPase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.2 pyrimidine-nucleoside phosphorylase

Engineering

Engineering on EC 2.4.2.2 - pyrimidine-nucleoside phosphorylase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
H169A
about 10% of wild-type activity
H169D
about 1% of wild-type activity
H169N
about 4% of wild-type activity
K162A
complete loss of activity
V220D
almost complete loss of activity
V220E
less than 0.5% of wild-type activity