2.4.2.19: nicotinate-nucleotide diphosphorylase (carboxylating) This is an abbreviated version! For detailed information about nicotinate-nucleotide diphosphorylase (carboxylating), go to the full flat file .
Word Map on EC 2.4.2.19
Reaction
beta-nicotinate D-ribonucleotide +
diphosphate +
CO2 =
pyridine-2,3-dicarboxylate +
5-phospho-alpha-D-ribose 1-diphosphate
Synonyms BNA6, general stress protein 70 , GSP70 , Hp-QAPRTase, hQPRTase, M6_Spy1061, NAD pyrophosphorylase, NadC, nicotinate mononucleotide pyrophosphorylase (carboxylating) (EC 2.4.2.19), nicotinate-nucleotide pyrophosphorylase (carboxylating), nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase (decarboxylating), pyrophosphorylase, nicotinate mononucleotide (carboxylating), QAPRTase, QPRT, QPRTase, QPRTase , QPT, QPT1, QPT2, quinolate phosphoribosyltransferase, quinolinate phosphoribosyl transferase, quinolinate phosphoribosyltansferase, quinolinate phosphoribosyltransferase, quinolinate phosphoribosyltransferase (decarboxylating), quinolinate phosphoribosyltransferase 1, quinolinate phosphoribosyltransferase 2, quinolinate phosphoribosyltransferase [decarboxylating] , quinolinic acid phosphoribosyl transferase, quinolinic acid phosphoribosyltransferase, quinolinic phosphoribosyltransferase, sp.NadC, spNadC, TM1645, type II quinolic acid phosphoribosyltransferase, type II quinolinic acid phosphoribosyltransferase
ECTree
General Information
General Information on EC 2.4.2.19 - nicotinate-nucleotide diphosphorylase (carboxylating)
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metabolism
key enzyme in the de novo nicotinamide adenine dinucleotide synthesis pathway
physiological function
-
overexpression and purification of the mutant enzymes produce 200-250 mg of protein/6 liter of culture similar to that of the wild-type enzyme
physiological function
interacts with active-caspase-3, depletion of quinolinate phosphoribosyltransferase protein increases intracellular caspase-3 activity, quinolinate phosphoribosyltransferase-depleted cells are highly sensitive to spontaneous cell death, quinolinate phosphoribosyltransferase protein prevents spontaneous cell death through inhibition of overproduction of active-caspase-3, identified as a caspase-3 binding protein, not a substrate for caspase-3
physiological function
the enzyme is essential for maintaining the homeostasis of quinolinic acid in the brain
physiological function
the enzyme inhibits hepatitis C virus replication via reduction of cellular lipogenesis
physiological function
-
the enzyme is involved in the biosynthetic pathway of the alkaloids nicotine and anabasine and also affects plant growth and development
physiological function
the enzyme with anti-apoptotic properties is a direct target gene of Wilms' tumor gene 1 in leukemic cells. Enzyme overexpression in K-562 leukemic cells increases resistance to imatinib