2.4.2.19: nicotinate-nucleotide diphosphorylase (carboxylating)

This is an abbreviated version!
For detailed information about nicotinate-nucleotide diphosphorylase (carboxylating), go to the full flat file.

Word Map on EC 2.4.2.19

2.4.2.19

nicotinic

3-hydroxyanthranilic

phthalic

tiazofurin

excitotoxin

kynureninase

5-phosphoribosyl-1-pyrophosphate

4.1.1.45

phosphoribosyltransferases

prtases

aminocarboxymuconate-semialdehyde

Reaction

Synonyms

BNA6, general stress protein 70 , GSP70 , Hp-QAPRTase, hQPRTase, M6_Spy1061, NAD pyrophosphorylase, NadC, nicotinate mononucleotide pyrophosphorylase (carboxylating) (EC 2.4.2.19), nicotinate-nucleotide pyrophosphorylase (carboxylating), nicotinate-nucleotide:pyrophosphate phospho-alpha-D-ribosyltransferase (decarboxylating), pyrophosphorylase, nicotinate mononucleotide (carboxylating), QAPRTase, QPRT, QPRTase, QPRTase , QPT, QPT1, QPT2, quinolate phosphoribosyltransferase, quinolinate phosphoribosyl transferase, quinolinate phosphoribosyltansferase, quinolinate phosphoribosyltransferase, quinolinate phosphoribosyltransferase (decarboxylating), quinolinate phosphoribosyltransferase 1, quinolinate phosphoribosyltransferase 2, quinolinate phosphoribosyltransferase [decarboxylating] , quinolinic acid phosphoribosyl transferase, quinolinic acid phosphoribosyltransferase, quinolinic phosphoribosyltransferase, sp.NadC, spNadC, TM1645, type II quinolic acid phosphoribosyltransferase, type II quinolinic acid phosphoribosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.2 Pentosyltransferases

2.4.2.19 nicotinate-nucleotide diphosphorylase (carboxylating)

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Results	in table
2	Activating Compound
35111	AA Sequence
1	CAS Registry Number
19	Cloned(Commentary)
1	Cofactor
18	Crystallization (Commentary)
62	Disease/ Diagnostics
2	Expression
7	General Information
4	IC50 Value
114	Inhibitors
23	kcat/KM [mM/s]
10	Ki Value [mM]
62	KM Value [mM]
27	Metals/Ions
36	Molecular Weight [Da]
33	Natural Substrates/ Products (Substrates)
59	Organism
10	Pathway
123	PDB ID
14	pH Optimum
3	pH Range
3	pH Stability
1	pI Value
1	Posttranslational Modification
31	Protein Variants
25	Purification (Commentary)
5	Reaction
2	Reaction Type
58	Reference
39	Source Tissue
23	Specific Activity [micromol/min/mg]
4	Storage Stability
74	Substrates and Products (Substrate)
27	Subunits
81	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
4	Temperature Stability [°C]
20	Turnover Number [1/s]

Disease

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Disease on EC 2.4.2.19 - nicotinate-nucleotide diphosphorylase (carboxylating)

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Acute Kidney Injury

De novo NAD+ biosynthetic impairment in acute kidney injury in humans.

30127395

Basal Ganglia Diseases

Immunohistochemical localization of quinolinic acid phosphoribosyltransferase in the human neostriatum.

1832752

Breast Neoplasms

Quinolinate Phosphoribosyltransferase Promotes Invasiveness of Breast Cancer Through Myosin Light Chain Phosphorylation.

33613454

Carcinoma

Determination of NAD pyrophosphorylase activity in biological samples.

1952057

Carcinoma, Hepatocellular

Biochemical mechanisms of resistance to tiazofurin.

3835825

Dementia

QPRTase modified N-doped carbon quantum dots: A fluorescent bioprobe for selective detection of neurotoxin quinolinic acid in human serum.

29054021

Glioma

The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress.

23548271

Hepatitis C

Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection.

28724915

Huntington Disease

Characterization of quinolinic acid phosphoribosyltransferase in human blood and observations in Huntington's disease.

2582090

Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum.

3159462

Leukemia

Biochemical mechanisms of resistance to tiazofurin.

3835825

Leukemia, Myeloid, Acute

Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells.

27889611

Neoplasms

Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA.

29541451

Studies on the mechanism of action of tiazofurin metabolism to an analog of NAD with potent IMP dehydrogenase-inhibitory activity.

6152729

Nervous System Diseases

QPRTase modified N-doped carbon quantum dots: A fluorescent bioprobe for selective detection of neurotoxin quinolinic acid in human serum.

29054021

Quinolinic-phosphoribosyl transferase activity is decreased in epileptic human brain tissue.

3409840

Neuroblastoma

Loss of the Chr16p11.2 ASD candidate gene QPRT leads to aberrant neuronal differentiation in the SH-SY5Y neuronal cell model.

30443311

Olivopontocerebellar Atrophies

Quinolinic acid catabolism is increased in cerebellum of patients with dominantly inherited olivopontocerebellar atrophy.

1825460

Tuberculosis

Biochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamide.

24949952

Crystal structure of quinolinic acid phosphoribosyltransferase from Mmycobacterium tuberculosis: a potential TB drug target.

9862811

Crystal structure of Sus scrofa quinolinate phosphoribosyltransferase in complex with nicotinate mononucleotide.

23626766

Virus Diseases

Quinolinate Phosphoribosyltransferase is an Antiviral Host Factor Against Hepatitis C Virus Infection.

28724915

Wilms Tumor

Anti-apoptotic quinolinate phosphoribosyltransferase (QPRT) is a target gene of Wilms' tumor gene 1 (WT1) protein in leukemic cells.

27889611