2.4.2.12: nicotinamide phosphoribosyltransferase

This is an abbreviated version!
For detailed information about nicotinamide phosphoribosyltransferase, go to the full flat file.

Reaction

Synonyms

eNAMPT, extracellular nicotinamide phosphoribosyltrasferase, iNAMPT, Nam phosphoribosyltransferase, NAmPRTase, Nampt, Nampt/PBEF/Visfatin, Nampt/visfatin, NAMPTA, NAMPTB, NAPRT, nicotinamide mononucleotide pyrophosphorylase, nicotinamide mononucleotide synthetase, nicotinamide phosphoribosyl transferase, nicotinamide phosphoribosyltransferase, nicotinamide phosphoribosyltransferase/Visfatin, NMN pyrophosphorylase, NMN synthetase, NMPRTase, PBEF, phosphoribosyltransferase, nicotinamide, pre-B cell colony enhancing factor, pre-B cell colony enhancing factor(PBEF), pre-B cell colony-enhancing factor, pre-B cell colony-enhancing factor (PBEF), pre-B cell colony-enhancing factor 1, pre-B colony enhancing factor, pre-B-cell colony enhancing factor, pre-B-cell colony-enhancing factor, Visfatin

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.12 nicotinamide phosphoribosyltransferase

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Results	in table
5	Activating Compound
1361	AA Sequence
9	Application
1	CAS Registry Number
19	Cloned(Commentary)
6	Cofactor
6	Crystallization (Commentary)
8669	Disease/ Diagnostics
11	Expression
27	General Information
2	General Stability
230	IC50 Value
417	Inhibitors
66	Ki Value [mM]
24	KM Value [mM]
13	Localization
9	Metals/Ions
8	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
76	Organism
3	Pathway
177	PDB ID
5	pH Optimum
3	pH Range
3	pH Stability
1	pI Value
2	Posttranslational Modification
27	Protein Variants
15	Purification (Commentary)
2	Reaction
7	Reaction Type
75	Reference
193	Source Tissue
12	Specific Activity [micromol/min/mg]
5	Storage Stability
80	Substrates and Products (Substrate)
15	Subunits
136	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Stability [°C]
10	Turnover Number [1/s]

pH Stability

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pH Stability on EC 2.4.2.12 - nicotinamide phosphoribosyltransferase

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pH STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

6.5 - 8.5

Homo sapiens

P43490

preincubation of 30 nM NAMPT for 1 h at 25 °C and various pH values, NMN synthesis: reaction started with 200 microM alpha-D-5-phosphoribosyl 1-diphosphate in presence of 1 microM nicotinamide, 1 mM ATP

690900

7 - 10

Rattus norvegicus

-

stable

489738

8.8

Rattus norvegicus

-

rapid inactivation below

489738