2.4.2.12: nicotinamide phosphoribosyltransferase
This is an abbreviated version!
For detailed information about nicotinamide phosphoribosyltransferase, go to the full flat file.
Word Map on EC 2.4.2.12
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2.4.2.12
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adipokines
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adiponectin
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leptin
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obesity
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adipose
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resistin
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adipocytokines
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nad+
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obese
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women
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adipocytes
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mellitus
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cardiovascular
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visceral
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necrosis
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salvage
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cholesterol
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sirt1
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endothelial
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tnf
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homa-ir
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triglyceride
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apelin
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sirtuins
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atherosclerosis
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c-reactive
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chemerin
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interleukin-6
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anthropometric
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insulin-mimetic
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ghrelin
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circumference
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overweight
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lean
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omentin
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polycystic
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adiposity
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waist
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vaspin
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pai-1
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hs-crp
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c-peptide
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obesity-related
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protein-4
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retinol-binding
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adipsin
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normal-weight
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index-matched
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pharmacology
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irisin
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medicine
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nmnats
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drug development
- 2.4.2.12
- adipokines
- adiponectin
- leptin
- obesity
- adipose
-
resistin
-
adipocytokines
- nad+
-
obese
- women
- adipocytes
- mellitus
- cardiovascular
- visceral
- necrosis
-
salvage
- cholesterol
- sirt1
- endothelial
- tnf
-
homa-ir
- triglyceride
- apelin
- sirtuins
- atherosclerosis
-
c-reactive
- chemerin
- interleukin-6
-
anthropometric
-
insulin-mimetic
- ghrelin
-
circumference
- overweight
-
lean
-
omentin
-
polycystic
-
adiposity
-
waist
- vaspin
- pai-1
-
hs-crp
- c-peptide
-
obesity-related
- protein-4
-
retinol-binding
- adipsin
-
normal-weight
-
index-matched
- pharmacology
-
irisin
- medicine
- nmnats
- drug development
Reaction
Synonyms
eNAMPT, extracellular nicotinamide phosphoribosyltrasferase, iNAMPT, Nam phosphoribosyltransferase, NAmPRTase, Nampt, Nampt/PBEF/Visfatin, Nampt/visfatin, NAMPTA, NAMPTB, NAPRT, nicotinamide mononucleotide pyrophosphorylase, nicotinamide mononucleotide synthetase, nicotinamide phosphoribosyl transferase, nicotinamide phosphoribosyltransferase, nicotinamide phosphoribosyltransferase/Visfatin, NMN pyrophosphorylase, NMN synthetase, NMPRTase, PBEF, phosphoribosyltransferase, nicotinamide, pre-B cell colony enhancing factor, pre-B cell colony enhancing factor(PBEF), pre-B cell colony-enhancing factor, pre-B cell colony-enhancing factor (PBEF), pre-B cell colony-enhancing factor 1, pre-B colony enhancing factor, pre-B-cell colony enhancing factor, pre-B-cell colony-enhancing factor, Visfatin
ECTree
2.4.2.12 nicotinamide phosphoribosyltransferaseAdvanced search results
results (
results (Source Tissue
Source Tissue on EC 2.4.2.12 - nicotinamide phosphoribosyltransferase
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
similar mRNA expression levels in (fa/fa) Zucker rats (obese) compared to lean Zucker rats (control) as well as in cafeteria diet-fed Wistar rats (diet-induced obesity) compared to standard chow diet-fed Wistar rats (control)
positive staining in blood vessels from arthritic joints as revealed by immunohistochemistry using rat monoclonal anti-murine NAMPT antibody
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release of NAMPT enzyme into the cell culture supernatant occurs constitutively. In primary hepatocytes, secretion within 24 h is far higher than the cellular content, but is neither influenced by inhibitors of secretion nor by glucose, insulin or TNFalpha. In primary human hepatocytes, secreted NAMPT is less active than intracellular enzyme
massive expression in synoviocytes of the synovial lining layer, sub-intimal synovium and pannus in joints from mice with type II collagen induced arthritis (CIA) compared to non-arthritic naive DBA/1 mice as revealed by immunohistochemistry using rat monoclonal anti-murine NAMPT antibody, some positive staining in chondrocytes from normal and arthritic joints and in blood vessels and inflammatory cells from arthritic joints
elevated levels in mice with type II collagen induced arthritis (CIA) compared to non-arthritic naive DBA/1 mice as revealed by ELISA using a mouse visfatin/PBEF ELISA kit
PBMC from blood from healthy individuals
(PEC) isolated from naive C57BL/6 mice of from lipopolysaccharide-treated mice
from individual with Hutchison-Gilford progeria syndrome associated with premature atherosclerosis, cell lifespan extension upon Nampt overexpression
similar mRNA expression levels in mesenteric, retroperitoneal and epididymal WAT depots of (fa/fa) Zucker rats (obese) compared to lean Zucker rats (control)
additional information
primary SMC culture stably expressing Nampt, 2.1 +/-0.3 additional population doublings constituting 34 +/-4% lifespan prolongation
primary SMC culture, Nampt expression declines as SMC approach senescence as detected by immunoblotting using rabbit-polyclonal anti-human Nampt/Pre-B-cell colony-enhancing factor antibody
some positive staining in cells of both normal and arthritic joints as revealed by immunohistochemistry using rat monoclonal anti-murine NAMPT antibody
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release of NAMPT enzyme into the cell culture supernatant occurs constitutively. HepG2 lysates and supernatants primarily contain the dimeric form of NAMPT which exhibit similar in vitro specific enzymatic activity
SMC clonal line stably expressing Nampt, 7.1 +/-3.1 fold higher Nampt activity, 6.3 +/-0.3 additional population doublings constituting 71 +/-7% lifespan prolongation, 19 +/-2% reduction in number of senescent cells at passage 37 compared to control HITC6 cells is dependent on SIRT1 activity and associated with increased p53 degradation and protection against oxidative cell damage as response to 150 microM hydrogen peroxide
SMC clonal line, Nampt expression declines as SMC approach senescence as detected by immunoblotting using rabbit-polyclonal anti-human Nampt/Pre-B-cell colony-enhancing factor antibody, 14 +/-3% of basal Nampt activity in presenescent SMC, direct relationship between Nampt activity and number of replication cycles preceeding senescence
elevated levels upon type II collagen induced arthritis (CIA) compared to non-arthritic naive DBA/1 mice as revealed by ELISA using a mouse visfatin/PBEF ELISA kit
lean Wistar rats: mRNA expression levels are maximal in mesenteric WAT (2.01 +/-0.08) followed by inguinal (1.23 +/-0.15), epididymal (0.88 +/-0.13), and retroperitoneal (0.79 +/-0.07) WAT
lean Zucker rats: mRNA expression levels are similar in subcutaneous (inguinal, 1.18 +/-0.33) and visceral (mesenteric (0.99 +/-0.15), retroperitoneal (0.56 +/-0.10), epididymal (1.17 +/-0.14)) WAT
mesenteric, significantly decreased mRNA expression level in cafeteria diet-fed Wistar rats (diet-induced obesity) compared to standard chow diet-fed Wistar rats (control)
significantly reduced mRNA expression level in (fa/fa) Zucker rats (obese) compared to lean Zucker rats (control) and in cafeteria diet-fed Wistar rats (diet-induced obesity) compared to standard chow diet-fed Wistar rats (control)
