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2.4.2.12: nicotinamide phosphoribosyltransferase

This is an abbreviated version!
For detailed information about nicotinamide phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.12

Reaction

nicotinamide D-ribonucleotide
+
diphosphate
=
nicotinamide
+
5-phospho-alpha-D-ribose 1-diphosphate

Synonyms

eNAMPT, extracellular nicotinamide phosphoribosyltrasferase, iNAMPT, Nam phosphoribosyltransferase, NAmPRTase, Nampt, Nampt/PBEF/Visfatin, Nampt/visfatin, NAMPTA, NAMPTB, NAPRT, nicotinamide mononucleotide pyrophosphorylase, nicotinamide mononucleotide synthetase, nicotinamide phosphoribosyl transferase, nicotinamide phosphoribosyltransferase, nicotinamide phosphoribosyltransferase/Visfatin, NMN pyrophosphorylase, NMN synthetase, NMPRTase, PBEF, phosphoribosyltransferase, nicotinamide, pre-B cell colony enhancing factor, pre-B cell colony enhancing factor(PBEF), pre-B cell colony-enhancing factor, pre-B cell colony-enhancing factor (PBEF), pre-B cell colony-enhancing factor 1, pre-B colony enhancing factor, pre-B-cell colony enhancing factor, pre-B-cell colony-enhancing factor, Visfatin

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.12 nicotinamide phosphoribosyltransferase

Reference

Reference on EC 2.4.2.12 - nicotinamide phosphoribosyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Preiss, J.; Handler, P.
Enzymatic synthesis of nicotinamide mononucleotide
J. Biol. Chem.
225
759-770
1957
Homo sapiens
Manually annotated by BRENDA team
Lin, L.F.H.; Lan, S.J.; Richardson, A.H.; Henderson, L.V.M.
Pyridine nucleotide synthesis. Purification of nicotinamide mononucleotide pyrophosphorylase from rat erythrocytes
J. Biol. Chem.
247
8016-8022
1972
Rattus norvegicus
Manually annotated by BRENDA team
Dietrich, L.S.; Muniz, O.
Inhibition of nicotinamide phosphoribosyltransferase by pyridine nucleotides
Biochemistry
11
1691-1695
1972
Rattus norvegicus
Manually annotated by BRENDA team
Elliott, G.C.; Rechsteiner, M.C.
Evidence for a physiologically active nicotinamide phosphoribosyltransferase in cultured human fibroblasts
Biochem. Biophys. Res. Commun.
104
996-1002
1982
Homo sapiens
Manually annotated by BRENDA team
Shibata, K.; Taguchi, H.; Nishitani, H.; Okumura, K.; Shimabayashi, Y.; Matsushita, N.; Yamazaki, H.
End product inhibition of the activity of nicotinamide phosphoribosyltransferase from various tissues of rats by NAD
Agric. Biol. Chem.
53
2283-2284
1989
Rattus norvegicus
-
Manually annotated by BRENDA team
Rocchigiani, M.; Micheli, V.; Duley, J.A.; Simmonds, H.A.
Determination of nicotinamide phosphoribosyltransferase activity in human erythrocytes: high-performance liquid chromatography-linked method
Anal. Biochem.
205
334-336
1992
Homo sapiens
Manually annotated by BRENDA team
Rongvaux, A.; Shea, R.J.; Mulks, M.H.; Gigot, D.; Urbain, J.; Leo, O.; Andris, F.
Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis
Eur. J. Immunol.
32
3225-3234
2002
Mus musculus
Manually annotated by BRENDA team
Martin, P.R.; Shea, R.J.; Mulks, M.H.
Identification of a plasmid-encoded gene from Haemophilus ducreyi which confers NAD independence
J. Bacteriol.
183
1168-1174
2001
[Haemophilus] ducreyi
Manually annotated by BRENDA team
Hasmann, M.; Schemainda, I.
FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis
Cancer Res.
63
7436-7442
2003
Homo sapiens
Manually annotated by BRENDA team
Revollo, J.R.; Grimm, A.A.; Imai, S.
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
J. Biol. Chem.
279
50754-50763
2004
Mus musculus (Q99KQ4), Mus musculus
Manually annotated by BRENDA team
Takahashi, R.; Nakamura, S.; Yoshida, T.; Kobayashi, Y.; Ohkubo, T.
Crystallization of human nicotinamide phosphoribosyltransferase
Acta Crystallogr. Sect. F
F63
375-377
2007
Homo sapiens (P43490), Homo sapiens
Manually annotated by BRENDA team
van der Veer, E.; Ho, C.; ONeil, C.; Barbosa, N.; Scott, R.; Cregan, S.P.; Pickering, J.G.
Extension of human cell lifespan by nicotinamide phosphoribosyltransferase
J. Biol. Chem.
282
10841-10845
2007
Homo sapiens, Homo sapiens (P43490)
Manually annotated by BRENDA team
Kim, M.K.; Lee, J.H.; Kim, H.; Park, S.J.; Kim, S.H.; Kang, G.B.; Lee, Y.S.; Kim, J.B.; Kim, K.K.; Suh, S.W.; Eom, S.H.
Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866
J. Mol. Biol.
362
66-77
2006
Rattus norvegicus (Q80Z29)
Manually annotated by BRENDA team
Khan, J.A.; Tao, X.; Tong, L.
Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents
Nat. Struct. Mol. Biol.
13
582-588
2006
Homo sapiens (P43490), Homo sapiens, Mus musculus (Q99KQ4), Mus musculus
Manually annotated by BRENDA team
Ashihara, H.; Stasolla, C.; Yin, Y.; Loukanina, N.; Thorpe, T.A.
De novo and salvage biosynthetic pathways of pyridine nucleotides and nicotinic acid conjugates in cultured plant cells
Plant Sci.
169
107-114
2005
no activity in Picea glauca
Manually annotated by BRENDA team
Takahashi, R.; Nakamura, S.; Yoshida, T.; Kobayashi, Y.; Ohkubo, T.
Crystallization of human nicotinamide phosphoribosyltransferase
Acta Crystallogr. Sect. F
63
375-377
2007
Homo sapiens (P43490), Homo sapiens
Manually annotated by BRENDA team
Burgos, E.S.; Schramm, V.L.
Weak Coupling of ATP Hydrolysis to the Chemical Equilibrium of Human Nicotinamide Phosphoribosyltransferase
Biochemistry
47
11086-11096
2008
Homo sapiens (P43490), Homo sapiens
Manually annotated by BRENDA team
Mercader, J.; Granados, N.; Caimari, A.; Oliver, P.; Bonet, M.L.; Palou, A.
Retinol-binding protein 4 and nicotinamide phosphoribosyltransferase/visfatin in rat obesity models
Horm. Metab. Res.
40
467-472
2008
Rattus norvegicus (Q80Z29), Rattus norvegicus
Manually annotated by BRENDA team
Busso, N.; Karababa, M.; Nobile, M.; Rolaz, A.; Van Gool, F.; Galli, M.; Leo, O.; So, A.; De Smedt, T.
Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD
PLoS ONE
3
e2267
2008
Homo sapiens (P43490), Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Beauparlant, P.; Bedard, D.; Bernier, C.; Chan, H.; Gilbert, K.; Goulet, D.; Gratton, M.O.; Lavoie, M.; Roulston, A.; Turcotte, E.; Watson, M.
Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777
Anticancer Drugs
20
346-354
2009
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Garten, A.; Petzold, S.; Barnikol-Oettler, A.; Koerner, A.; Thasler, W.E.; Kratzsch, J.; Kiess, W.; Gebhardt, R.
Nicotinamide phosphoribosyltransferase (NAMPT/PBEF/visfatin) is constitutively released from human hepatocytes
Biochem. Biophys. Res. Commun.
391
376-381
2010
Homo sapiens
Manually annotated by BRENDA team
Hsu, C.P.; Oka, S.; Shao, D.; Hariharan, N.; Sadoshima, J.
Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes
Circ. Res.
105
481-491
2009
Mus musculus
Manually annotated by BRENDA team
Takahashi, R.; Nakamura, S.; Nakazawa, T.; Minoura, K.; Yoshida, T.; Nishi, Y.; Kobayashi, Y.; Ohkubo, T.
Structure and reaction mechanism of human nicotinamide phosphoribosyltransferase
J. Biochem.
147
95-107
2010
Homo sapiens (P43490), Homo sapiens
Manually annotated by BRENDA team
Colombano, G.; Travelli, C.; Galli, U.; Caldarelli, A.; Chini, M.G.; Canonico, P.L.; Sorba, G.; Bifulco, G.; Tron, G.C.; Genazzani, A.A.
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry
J. Med. Chem.
53
616-623
2010
Homo sapiens (P43490)
Manually annotated by BRENDA team
Zhang, R.Y.; Qin, Y.; Lv, X.Q.; Wang, P.; Xu, T.Y.; Zhang, L.; Miao, C.Y.
A fluorometric assay for high-throughput screening targeting nicotinamide phosphoribosyltransferase
Anal. Biochem.
412
18-25
2011
Mus musculus
Manually annotated by BRENDA team
Olesen, U.; Petersen, J.; Garten, A.; Kiess, W.; Yoshino, J.; Imai, S.; Christensen, M.; Fristrup, P.; Thougaard, A.; Björkling, F.; Jensen, P.; Nielsen, S.; Sehested, M.
Target enzyme mutations are the molecular basis for resistance towards pharmacological inhibition of nicotinamide phosphoribosyltransferase
BMC Cancer
10
677
2010
Homo sapiens (P43490)
Manually annotated by BRENDA team
Friebe, D.; Neef, M.; Kratzsch, J.; Erbs, S.; Dittrich, K.; Garten, A.; Petzold-Quinque, S.; Blueher, S.; Reinehr, T.; Stumvoll, M.; Blueher, M.; Kiess, W.; Koerner, A.
Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans
Diabetologia
54
1200-1211
2011
Homo sapiens
Manually annotated by BRENDA team
Dahl, T.; Ranheim, T.; Holm, S.; Berge, R.; Aukrust, P.; Halvorsen, B.
Nicotinamide phosphoribosyltransferase and lipid accumulation in macrophages
Eur. J. Clin. Invest.
41
1098-1104
2011
Homo sapiens
Manually annotated by BRENDA team
Zhang, L.Q.; Heruth, D.P.; Ye, S.Q.
Nicotinamide phosphoribosyltransferase in human diseases
J. Bioanal. Biomed.
3
13-25
2011
Homo sapiens (P43490), Homo sapiens
Manually annotated by BRENDA team
Pittelli, M.; Formentini, L.; Faraco, G.; Lapucci, A.; Rapizzi, E.; Cialdai, F.; Romano, G.; Moneti, G.; Moroni, F.; Chiarugi, A.
Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD pool
J. Biol. Chem.
285
34106-34114
2010
Homo sapiens
Manually annotated by BRENDA team
Hong, E.H.; Yun, H.S.; Kim, J.; Um, H.D.; Lee, K.H.; Kang, C.M.; Lee, S.J.; Chun, J.S.; Hwang, S.G.
Nicotinamide phosphoribosyltransferase is essential for interleukin-1beta-mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal-regulated kinase (ERK) complex signaling
J. Biol. Chem.
286
28619-28631
2011
Oryctolagus cuniculus
Manually annotated by BRENDA team
Zhang, H.S.; Sang, W.W.; Wang, Y.O.; Liu, W.
Nicotinamide phosphoribosyltransferase/sirtuin 1 pathway is involved in human immunodeficiency virus type 1 Tat-mediated long terminal repeat transactivation
J. Cell. Biochem.
110
1464-1470
2010
Homo sapiens
Manually annotated by BRENDA team
Hara, N.; Yamada, K.; Shibata, T.; Osago, H.; Tsuchiya, M.
Nicotinamide phosphoribosyltransferase/visfatin does not catalyze nicotinamide mononucleotide formation in blood plasma
PLoS ONE
6
e22781
2011
Homo sapiens
Manually annotated by BRENDA team
Bowlby, S.C.; Thomas, M.J.; D'Agostino, R.B.; Kridel, S.J.
Nicotinamide phosphoribosyl transferase (Nampt) is required for de novo lipogenesis in tumor cells
PLoS ONE
7
e40195
2012
Homo sapiens
Manually annotated by BRENDA team
Liu, L.; Wang, F.; Zhang, X.; Huang, P.; Lu, Y.; Wei, E.; Zhang, W.
Nicotinamide phosphoribosyltransferase may be involved in age-related brain diseases
PLoS ONE
7
e44933
2012
Mus musculus
Manually annotated by BRENDA team
Zheng, X.; Bair, K.W.; Bauer, P.; Baumeister, T.; Bowman, K.K.; Buckmelter, A.J.; Caligiuri, M.; Clodfelter, K.H.; Feng, Y.; Han, B.; Ho, Y.C.; Kley, N.; Li, H.; Liang, X.; Liederer, B.M.; Lin, J.; Ly, J.; OBrien, T.; Oeh, J.; Oh, A.; Reynolds, D.J.; Sampath, D.; Sharma, G.; Skelton, N.; Smith, C.C.; Tremayne, J.
Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)
Bioorg. Med. Chem. Lett.
23
5488-5497
2013
Homo sapiens (P43490), Homo sapiens
Manually annotated by BRENDA team
Zheng, X.; Baumeister, T.; Buckmelter, A.J.; Caligiuri, M.; Clodfelter, K.H.; Han, B.; Ho, Y.C.; Kley, N.; Lin, J.; Reynolds, D.J.; Sharma, G.; Smith, C.C.; Wang, Z.; Dragovich, P.S.; Oh, A.; Wang, W.; Zak, M.; Wang, Y.; Yuen, P.W.; Bair, K.W.
Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors
Bioorg. Med. Chem. Lett.
24
337-343
2014
Homo sapiens (P43490)
Manually annotated by BRENDA team
Clark, D.E.; Waszkowycz, B.; Wong, M.; Lockey, P.M.; Adalbert, R.; Gilley, J.; Clark, J.; Coleman, M.P.
Application of virtual screening to the discovery of novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with potential for the treatment of cancer and axonopathies
Bioorg. Med. Chem. Lett.
26
2920-2926
2016
Homo sapiens (P43490)
Manually annotated by BRENDA team
Chen, W.; Dong, G.; He, S.; Xu, T.; Wang, X.; Liu, N.; Zhang, W.; Miao, C.; Sheng, C.
Identification of benzothiophene amides as potent inhibitors of human nicotinamide phosphoribosyltransferase
Bioorg. Med. Chem. Lett.
26
765-768
2016
Homo sapiens (P43490), Homo sapiens
Manually annotated by BRENDA team
Grolla, A.A.; Travelli, C.; Genazzani, A.A.; Sethi, J.K.
Extracellular nicotinamide phosphoribosyltransferase, a new cancer metabokine
Br. J. Pharmacol.
173
2182-2194
2016
Homo sapiens (P43490)
Manually annotated by BRENDA team
Hsu, C.P.; Yamamoto, T.; Oka, S.; Sadoshima, J.
The function of nicotinamide phosphoribosyltransferase in the heart
DNA Repair
23
64-68
2014
Homo sapiens (P43490)
Manually annotated by BRENDA team
Fang, C.; Guan, L.; Zhong, Z.; Gan, X.; He, S.
Analysis of the nicotinamide phosphoribosyltransferase family provides insight into vertebrate adaptation to different oxygen levels during the water-to-land transition
FEBS J.
282
2858-2878
2015
Danio rerio
Manually annotated by BRENDA team
Marletta, A.S.; Massarotti, A.; Orsomando, G.; Magni, G.; Rizzi, M.; Garavaglia, S.
Crystal structure of human nicotinic acid phosphoribosyltransferase
FEBS Open Bio
5
419-428
2015
Homo sapiens (P43490), Homo sapiens
Manually annotated by BRENDA team
Pittelli, M.; Cavone, L.; Lapucci, A.; Oteri, C.; Felici, R.; Niccolai, E.; Amedei, A.; Chiarugi, A.
Nicotinamide phosphoribosyltransferase (NAMPT) activity is essential for survival of resting lymphocytes
Immunol. Cell Biol.
92
191-199
2014
Homo sapiens (P43490), Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Tan, B.; Young, D.; Lu, Z.; Wang, T.; Meier, T.; Shepard, R.; Roth, K.; Zhai, Y.; Huss, K.; Kuo, M.; Gillig, J.; Parthasarathy, S.; Burkholder, T.; Smith, M.; Geeganage, S.; Zhao, G.
Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: Metabolic basis and potential clinical implications
J. Biol. Chem.
288
3500-3511
2013
Homo sapiens (P43490), Homo sapiens
Manually annotated by BRENDA team
Zheng, X.; Bauer, P.; Baumeister, T.; Buckmelter, A.J.; Caligiuri, M.; Clodfelter, K.H.; Han, B.; Ho, Y.C.; Kley, N.; Lin, J.; Reynolds, D.J.; Sharma, G.; Smith, C.C.; Wang, Z.; Dragovich, P.S.; Gunzner-Toste, J.; Liederer, B.M.; Ly, J.; OBrien, T.; Oh, A.; Wang, L.; Wang, W.; Xiao, Y.; Zak, M.; Zhao, G.; Yue, Y.u.e.n.
Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
J. Med. Chem.
56
6413-6433
2013
Homo sapiens (P43490)
Manually annotated by BRENDA team
Xu, T.Y.; Zhang, S.L.; Dong, G.Q.; Liu, X.Z.; Wang, X.; Lv, X.Q.; Qian, Q.J.; Zhang, R.Y.; Sheng, C.Q.; Miao, C.Y.
Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase
Sci. Rep.
5
10043
2015
Homo sapiens
Manually annotated by BRENDA team
Zabka, T.S.; Singh, J.; Dhawan, P.; Liederer, B.M.; Oeh, J.; Kauss, M.A.; Xiao, Y.; Zak, M.; Lin, T.; McCray, B.; La, N.; Nguyen, T.; Beyer, J.; Farman, C.; Uppal, H.; Dragovich, P.S.; OBrien, T.; Sampath, D.; Misner, D.L.
Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase
Toxicol. Sci.
144
163-172
2015
Homo sapiens (P43490), Homo sapiens, Rattus norvegicus (Q80Z29)
Manually annotated by BRENDA team
Oita, R.C.; Camp, S.M.; Ma, W.; Ceco, E.; Harbeck, M.; Singleton, P.; Messana, J.; Sun, X.; Wang, T.; Garcia, J.G.N.
Novel mechanism for nicotinamide phosphoribosyltransferase inhibition of TNF-alpha-mediated apoptosis in human lung endothelial cells
Am. J. Respir. Cell Mol. Biol.
59
36-44
2018
Homo sapiens (P43490), Homo sapiens
Manually annotated by BRENDA team
Molugu, T.R.; Oita, R.C.; Chawla, U.; Camp, S.M.; Brown, M.F.; Garcia, J.G.N.
Nicotinamide phosphoribosyltransferase purification using SUMO expression system
Anal. Biochem.
598
113597
2020
Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Asawa, Y.; Katsuragi, K.; Sato, A.; Yoshimori, A.; Tanuma, S.I.; Nakamura, H.
Structure-based drug design of novel carborane-containing nicotinamide phosphoribosyltransferase inhibitors
Bioorg. Med. Chem.
27
2832-2844
2019
Homo sapiens (P43490)
Manually annotated by BRENDA team
Curtin, M.L.; Heyman, H.R.; Clark, R.F.; Sorensen, B.K.; Doherty, G.A.; Hansen, T.M.; Frey, R.R.; Sarris, K.A.; Aguirre, A.L.; Shrestha, A.; Tu, N.; Woller, K.; Pliushchev, M.A.; Sweis, R.F.; Cheng, M.; Wilsbacher, J.L.; Kovar, P.J.; Guo, J.; Cheng, D.; Longenecker, K.L.; Raich, D.; Korepanova, A.V.; Soni, N.B.; Algire, M.A.
SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)
Bioorg. Med. Chem. Lett.
27
3317-3325
2017
Homo sapiens (P43490)
Manually annotated by BRENDA team
Zhang, K.; Ni, Y.; Chen, J.; Tu, Z.; Wu, X.; Chen, D.; Yao, H.; Jiang, S.
Discovery of trans-3-(pyridin-3-yl)acrylamide-derived sulfamides as potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors for the potential treatment of cancer
Bioorg. Med. Chem. Lett.
29
1502-1506
2019
Homo sapiens (P43490)
Manually annotated by BRENDA team
Zhang, L.Q.; Van Haandel, L.; Xiong, M.; Huang, P.; Heruth, D.P.; Bi, C.; Gaedigk, R.; Jiang, X.; Li, D.Y.; Wyckoff, G.; Grigoryev, D.N.; Gao, L.; Li, L.; Wu, M.; Leeder, J.S.; Ye, S.Q.
Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase
Cell Death Dis.
8
e2705
2017
Mus musculus (Q99KQ4), Mus musculus
Manually annotated by BRENDA team
Torretta, S.; Colombo, G.; Travelli, C.; Boumya, S.; Lim, D.; Genazzani, A.A.; Grolla, A.A.
The cytokine nicotinamide phosphoribosyltransferase (eNAMPT; PBEF; visfatin) acts as a natural antagonist of C-C chemokine receptor type 5 (CCR5)
Cells
9
496
2020
Homo sapiens (P43490), Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Aprile, S.; Galli, U.; Tron, G.C.; Del Grosso, E.; Travelli, C.; Grosa, G.
Data on metabolic stability, aqueous solubility and CYP inhibition of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors
Data Brief
28
105034
2020
Homo sapiens (P43490)
Manually annotated by BRENDA team
Travelli, C.; Aprile, S.; Mattoteia, D.; Colombo, G.; Clemente, N.; Scanziani, E.; Terrazzino, S.; Alisi, M.A.; Polenzani, L.; Grosa, G.; Genazzani, A.A.; Tron, G.C.; Galli, U.
Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group
Eur. J. Med. Chem.
181
111576
2019
Homo sapiens (P43490)
Manually annotated by BRENDA team
Kong, J.; Du, C.; Jiang, L.; Jiang, W.; Deng, P.; Shao, X.; Zhang, B.; Li, Y.; Zhu, R.; Zhao, Q.; Fu, D.; Gu, H.; Luo, L.; Long, H.; Zhao, Y.; Cen, X.
Nicotinamide phosphoribosyltransferase regulates cocaine reward through sirtuin 1
Exp. Neurol.
307
52-61
2018
Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Feng, D.; Xu, D.; Murakoshi, N.; Tajiri, K.; Qin, R.; Yonebayashi, S.; Okabe, Y.; Li, S.; Yuan, Z.; Aonuma, K.; Ieda, M.
Nicotinamide phosphoribosyltransferase (Nampt)/nicotinamide adenine dinucleotide (NAD) axis suppresses atrial fibrillation by modulating the calcium handling pathway
Int. J. Mol. Sci.
21
4655
2020
Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Svoboda, P.; Krizova, E.; Sestakova, S.; Vapenkova, K.; Knejzlik, Z.; Rimpelova, S.; Rayova, D.; Volfova, N.; Krizova, I.; Rumlova, M.; Sykora, D.; Kizek, R.; Haluzik, M.; Zidek, V.; Zidkova, J.; Skop, V.
Nuclear transport of nicotinamide phosphoribosyltransferase is cell cycle-dependent in mammalian cells, and its inhibition slows cell growth
J. Biol. Chem.
294
8676-8689
2019
Homo sapiens (P43490), Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Travelli, C.; Aprile, S.; Rahimian, R.; Grolla, A.A.; Rogati, F.; Bertolotti, M.; Malagnino, F.; di Paola, R.; Impellizzeri, D.; Fusco, R.; Mercalli, V.; Massarotti, A.; Stortini, G.; Terrazzino, S.; Del Grosso, E.; Fakhfouri, G.; Troiani, M.P.; Alisi, M.A.; Grosa, G.; Sorba, G.; Canonico, P.L.; Orsomando, G.
Identification of novel triazole-based nicotinamide phosphoribosyltransferase (NAMPT) inhibitors endowed with antiproliferative and antiinflammatory activity
J. Med. Chem.
60
1768-1792
2017
Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Szefler, B.; Czelen, P.
Potential inhibitory effect of indolizine derivatives on the two enzymes nicotinamide phosphoribosyltransferase and beta lactamase, a molecular dynamics study
J. Mol. Model.
23
208
2017
Homo sapiens (P43490)
Manually annotated by BRENDA team
Huang, X.; Xing, S.; Chen, C.; Yu, Z.; Chen, J.
Salidroside protects PC12 cells from Abeta1-40-induced cytotoxicity by regulating the nicotinamide phosphoribosyltransferase signaling pathway
Mol. Med. Rep.
16
2700-2706
2017
Rattus norvegicus (Q80Z29)
Manually annotated by BRENDA team
Hara, N.; Osago, H.; Hiyoshi, M.; Kobayashi-Miura, M.; Tsuchiya, M.
Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry
PLoS ONE
14
e0214000
2019
Homo sapiens (P43490), Rattus norvegicus (Q80Z29), Mus musculus (Q99KQ4)
Manually annotated by BRENDA team
Gao, H.; Chen, J.; Chen, T.; Wang, Y.; Song, Y.; Dong, Y.; Zhao, S.; Machado, R.F.
MicroRNA410 inhibits pulmonary vascular remodeling via regulation of nicotinamide phosphoribosyltransferase
Sci. Rep.
9
9949
2019
Homo sapiens (P43490), Homo sapiens
Manually annotated by BRENDA team
Audrito, V.; Manago, A.; Gaudino, F.; Deaglio, S.
Targeting metabolic reprogramming in metastatic melanoma The key role of nicotinamide phosphoribosyltransferase (NAMPT)
Semin. Cell Dev. Biol.
98
192-201
2020
Homo sapiens (P43490)
Manually annotated by BRENDA team