2.4.2.12: nicotinamide phosphoribosyltransferase
This is an abbreviated version!
For detailed information about nicotinamide phosphoribosyltransferase, go to the full flat file.
Word Map on EC 2.4.2.12
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2.4.2.12
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adipokines
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adiponectin
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leptin
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obesity
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adipose
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resistin
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adipocytokines
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nad+
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obese
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women
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adipocytes
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mellitus
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cardiovascular
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visceral
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necrosis
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salvage
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cholesterol
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sirt1
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endothelial
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tnf
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homa-ir
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triglyceride
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apelin
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sirtuins
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atherosclerosis
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c-reactive
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chemerin
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interleukin-6
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anthropometric
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insulin-mimetic
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ghrelin
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circumference
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overweight
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lean
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omentin
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polycystic
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adiposity
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waist
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vaspin
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pai-1
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hs-crp
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c-peptide
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obesity-related
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protein-4
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retinol-binding
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adipsin
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normal-weight
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index-matched
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pharmacology
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irisin
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medicine
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nmnats
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drug development
- 2.4.2.12
- adipokines
- adiponectin
- leptin
- obesity
- adipose
-
resistin
-
adipocytokines
- nad+
-
obese
- women
- adipocytes
- mellitus
- cardiovascular
- visceral
- necrosis
-
salvage
- cholesterol
- sirt1
- endothelial
- tnf
-
homa-ir
- triglyceride
- apelin
- sirtuins
- atherosclerosis
-
c-reactive
- chemerin
- interleukin-6
-
anthropometric
-
insulin-mimetic
- ghrelin
-
circumference
- overweight
-
lean
-
omentin
-
polycystic
-
adiposity
-
waist
- vaspin
- pai-1
-
hs-crp
- c-peptide
-
obesity-related
- protein-4
-
retinol-binding
- adipsin
-
normal-weight
-
index-matched
- pharmacology
-
irisin
- medicine
- nmnats
- drug development
Reaction
Synonyms
eNAMPT, extracellular nicotinamide phosphoribosyltrasferase, iNAMPT, Nam phosphoribosyltransferase, NAmPRTase, Nampt, Nampt/PBEF/Visfatin, Nampt/visfatin, NAMPTA, NAMPTB, NAPRT, nicotinamide mononucleotide pyrophosphorylase, nicotinamide mononucleotide synthetase, nicotinamide phosphoribosyl transferase, nicotinamide phosphoribosyltransferase, nicotinamide phosphoribosyltransferase/Visfatin, NMN pyrophosphorylase, NMN synthetase, NMPRTase, PBEF, phosphoribosyltransferase, nicotinamide, pre-B cell colony enhancing factor, pre-B cell colony enhancing factor(PBEF), pre-B cell colony-enhancing factor, pre-B cell colony-enhancing factor (PBEF), pre-B cell colony-enhancing factor 1, pre-B colony enhancing factor, pre-B-cell colony enhancing factor, pre-B-cell colony-enhancing factor, Visfatin
ECTree
2.4.2.12 nicotinamide phosphoribosyltransferaseAdvanced search results
results (
results (KM Value
KM Value on EC 2.4.2.12 - nicotinamide phosphoribosyltransferase
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KM VALUE [mM] 
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
0.44
ADP
+/-0.05 mM, ADP-ATP radiolabel exchange in absence of other reactants
0.18
phosphate
+/-0.02 mM, pH 7.5, 88 nM NAMPT, HPLC-based quantification
0.00063
alpha-D-5-phosphoribosyl 1-diphosphate
+/-0.00003 mM, in presence of 2 mM ATP the Km is lowered 10-fold, calculated from apparent KM by extrapolation to correct for inhibition by NAD+ in the continuous fluorimetric assay, pH 7.5, 125 nM nicotinamide, 2.2 nM NAMPT
0.0072
alpha-D-5-phosphoribosyl 1-diphosphate
+/-0.0006 mM, pH 7.5, 1 microM nicotinamide, 88 nM NAMPT, HPLC-based quantification
0.0117
alpha-D-5-phosphoribosyl 1-diphosphate
+/-0.0008 mM, in presence of 2 mM phosphate, pH 7.5, 1 microM nicotinamide, 88 nM NAMPT, HPLC-based quantification
2.2
ATP
+/-0.2 mM, ADP-ATP radiolabel exchange in absence of other reactants
7.4
ATP
+/-1.5 mM, in presence of 2 mM phosphate, pH 7.5, 100 nM nicotinamide, 50 microM PRPP, 2.2 nM NAMPT
0.000005
nicotinamide
+/-0.000002 mM, in presence of 2 mM ATP the Km is 150-fold lowered, calculated from apparent KM by extrapolation to correct for inhibition by NAD+ in the continuous fluorimetric assay, pH 7.5, 200 microM PRPP, 2.8 nM NAMPT
0.000235
nicotinamide
+/-0.000017 mM, in presence of 2 mM phosphate, pH 7.5, 100 microM PRPP, 88 nM NAMPT, HPLC-based quantification
0.000855
nicotinamide
+/-0.000022 mM, pH 7.5, 100 microM PRPP, 88 nM NAMPT, HPLC-based quantification
