2.4.2.10: orotate phosphoribosyltransferase
This is an abbreviated version!
For detailed information about orotate phosphoribosyltransferase, go to the full flat file.
Word Map on EC 2.4.2.10
-
2.4.2.10
-
pyrimidine
-
5-fluorouracil
-
thymidylate
-
dihydropyrimidine
-
uridine
-
thymidine
-
uracil
-
colorectal
-
dihydroorotase
-
pyre
-
fluoropyrimidine
-
4.1.1.23
-
orotidine-5'-monophosphate
-
5-fluoroorotic
-
transcarbamoylase
-
5-fu-based
-
leucovorin
-
phosphoribosylpyrophosphate
-
5-fluorouracil-based
-
5-fu-related
-
prototrophy
-
tegafur
-
odcase
-
dihydrouracil
-
succinate-grown
-
5-phosphoribosyl
-
fdump
-
5-fu-resistant
-
podospora
-
phosphoribosyltransferases
-
5-fluoro-2'-deoxyuridine
-
fluoropyrimidine-based
-
ompdc
-
5-phosphoribosyl-1-pyrophosphate
-
anserina
-
1-pyrophosphate
-
5-fluorouridine
-
pyrophosphorolysis
-
medicine
-
diagnostics
- 2.4.2.10
- pyrimidine
- 5-fluorouracil
- thymidylate
- dihydropyrimidine
- uridine
- thymidine
- uracil
- colorectal
- dihydroorotase
-
pyre
-
fluoropyrimidine
-
4.1.1.23
- orotidine-5'-monophosphate
-
5-fluoroorotic
-
transcarbamoylase
-
5-fu-based
- leucovorin
-
phosphoribosylpyrophosphate
-
5-fluorouracil-based
-
5-fu-related
-
prototrophy
-
tegafur
- odcase
- dihydrouracil
-
succinate-grown
-
5-phosphoribosyl
- fdump
-
5-fu-resistant
- podospora
-
phosphoribosyltransferases
- 5-fluoro-2'-deoxyuridine
-
fluoropyrimidine-based
- ompdc
-
5-phosphoribosyl-1-pyrophosphate
- anserina
- 1-pyrophosphate
- 5-fluorouridine
-
pyrophosphorolysis
- medicine
- diagnostics
Reaction
Synonyms
More, OMP synthase, OPRT, OPRTase, orotate phosphoribosyl pyrophosphate transferase, orotate phosphoribosyl transferase, orotate phosphoribosyltransferase, orotate PRTase, orotic acid phosphoribosyltransferase, orotidine 5'-monophosphate pyrophosphorylase, orotidine 5'-phosphate pyrophosphorylase, orotidine monophosphate pyrophosphorylase, orotidine phosphoribosyltransferase, orotidine-5'-phosphate pyrophosphorylase, orotidylate phosphoribosyltransferase, orotidylate pyrophosphorylase, orotidylic acid phosphorylase, orotidylic acid pyrophosphorylase, orotidylic phosphorylase, orotidylic pyrophosphorylase, phosphoribosyltransferase, orotate, Pyr5, PyrE, rv0382c, type I phosphoribosyltransferase, ura5
ECTree
2.4.2.10 orotate phosphoribosyltransferaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 2.4.2.10 - orotate phosphoribosyltransferase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
5-fluoroorotate + 5-phospho-alpha-D-ribose 1-diphosphate
?
-
-
-
?
5-fluoroorotate + phosphoribose diphosphate
5-fluoroorotidine 5'-phosphate + diphosphate
-
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
orotate + 5-alpha-D-phosphorylribose 1-diphosphate
diphosphate + orotidine 5'-phosphate
-
-
-
-
?
orotate methylester + phosphoribose diphosphate
diphosphate + orotidine 4-methylester
-
-
-
-
?
uracil + phosphoribose diphosphate
diphosphate + uridine
-
-
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
-
-
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
-
essential enzyme for activation of 5-fluorouracil and its derivatives
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
-
the activating OPRT and its antagonist the catabolizing dihydropyrimidine dehydrogenase play important roles in 5-fluorouracil metabolism, overview
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
-
the enzyme is involved in degradation of 5-fluorouracil being the key enzyme related to the first-step activation process of 5-fluorouracil, and possibly predicts chemosensitivity to 5-fluorouracil, overview
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
-
the enzyme is involved in the de novo biosynthesis of pyrimidine nucleotides, main enzyme involved in phosphoribosylation of 5-fluorouracil, an essential step that leads to tumor growth inhibition
-
-
?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
5-fluorouridine 5'-phosphate + diphosphate
-
the enzyme is involved in the metabolism of 5-fluorouracil, a chemotherapeutic drug in treatment of solid cancers, major pathways of 5-fluorouracil metabolism, overview
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
reverse reaction: tri-, tetrapoly- or trimetaphosphate can replace diphosphate with 29%, 70% or 78% efficiency
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
involved in de novo synthesis of pyrimidine nucleotides
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
final steps in biosynthesis of UMP
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
i.e. orotidylate or OMP
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
final steps in biosynthesis of UMP
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
final steps in biosynthesis of UMP
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
Pyricularia oryzae ATCC MYA-4617
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
catalyzes stereospecific formation of beta-glycosidic bond between orotate and ribose 5'-phosphate portion of phospho-ribose diphosphate
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
predominant species of phosphoribose diphosphate: metal ion complex
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
high specificity for orotate
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
nucleotide-forming step in pyrimidine biosynthesis
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
involved in de novo synthesis of pyrimidine nucleotides
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
?
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
orotidine 5'-phosphate + diphosphate
-
-
-
-
r
orotidine + diphosphate
orotate + alpha-D-ribose 1-diphosphate
-
-
-
-
?
orotidine + diphosphate
orotate + alpha-D-ribose 1-diphosphate
-
-
-
-
r
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
r
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
r
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
r
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
orotidine 5'-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
r
orotidine 5-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
-
-
-
?
orotidine 5-phosphate + diphosphate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate
-
the compounds bind very tightly to the enzyme in a Mg2+-dependent manner, overview
the compounds bind very tightly to the enzyme in a Mg2+-dependent manner, overview
-
?
additional information
?
-
-
enzyme from mammals is a bifunctional polypeptide, it also catalyzes the reaction listed as EC 4.1.1.23
-
-
?
additional information
?
-
-
relationship between OPRT, antagonizing dihydropyrimidine dehydrogenase, and clinicopathologic features in cancer and treatment with 5-fluorouracil, relation of patients survival and enzyme activities after surgery, detailed overview
-
-
?
additional information
?
-
-
the enzyme expression is weakly correlated to 5-fluorouracil sensitivity and apoptotic cell rate, overview
-
-
?
additional information
?
-
-
the enzyme is associated with thymidylate synthase and dihydropyrimidine dehydrogenase in resectable colorectal cancer, overview, prognostic impact of the enzyme among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy, overview
-
-
?
additional information
?
-
-
enzyme from mammals is a bifunctional polypeptide, it also catalyzes the reaction listed as EC 4.1.1.23
-
-
?
additional information
?
-
-
enzyme from mammals is a bifunctional polypeptide, it also catalyzes the reaction listed as EC 4.1.1.23
-
-
?
additional information
?
-
-
half-of-sites binding of orotidine 5-phosphate and alpha-D-5-phosphorylribose 1-diphosphate to the enzyme supports an alternative variant of the Theorell-Chance mechanism with alternating site catalysis, overview
-
-
?
additional information
?
-
-
enzyme from mammals is a bifunctional polypeptide, it also catalyzes the reaction listed as EC 4.1.1.23
-
-
?
