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2.4.2.10: orotate phosphoribosyltransferase

This is an abbreviated version!
For detailed information about orotate phosphoribosyltransferase, go to the full flat file.

Word Map on EC 2.4.2.10

Reaction

orotidine 5'-phosphate
+
diphosphate
=
Orotate
+
5-phospho-alpha-D-ribose 1-diphosphate

Synonyms

More, OMP synthase, OPRT, OPRTase, orotate phosphoribosyl pyrophosphate transferase, orotate phosphoribosyl transferase, orotate phosphoribosyltransferase, orotate PRTase, orotic acid phosphoribosyltransferase, orotidine 5'-monophosphate pyrophosphorylase, orotidine 5'-phosphate pyrophosphorylase, orotidine monophosphate pyrophosphorylase, orotidine phosphoribosyltransferase, orotidine-5'-phosphate pyrophosphorylase, orotidylate phosphoribosyltransferase, orotidylate pyrophosphorylase, orotidylic acid phosphorylase, orotidylic acid pyrophosphorylase, orotidylic phosphorylase, orotidylic pyrophosphorylase, phosphoribosyltransferase, orotate, Pyr5, PyrE, rv0382c, type I phosphoribosyltransferase, ura5

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.10 orotate phosphoribosyltransferase

Specific Activity

Specific Activity on EC 2.4.2.10 - orotate phosphoribosyltransferase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0000045
-
untransfected TMK-1 cells
0.000009
-
untransfected MKN-45 cells
0.000072
-
transfected MKN-45-OPRT cells
0.000172
-
transfected TMK-OPRT cells
0.115
-
-
0.41
-
mutant
0.69
-
-
15.2
-
wild-type
2
crude enzyme, at pH 8.0, temperature not specified in the publication
225
-
recombinant enzyme after 17fold purification, in the presence of Mn2+
24
-
recombinant enzyme from crude cell extract, in the presence of Mg2+
3 - 8
wild type enzyme
4.32
-
37 °C, pH 8.0
423
-
recombinant enzyme after 17fold purification, in the presence of Mg2+
45
-
in the absence of added OMP-decarboxylase, EC 4.1.1.23
65
-
in the presence of added OMP-decarboxylase, EC 4.1.1.23
71
-
recombinant enzyme after 17fold purification, in the presence of Co2+
additional information