2.4.2.10: orotate phosphoribosyltransferase

This is an abbreviated version!
For detailed information about orotate phosphoribosyltransferase, go to the full flat file.

Reaction

Synonyms

More, OMP synthase, OPRT, OPRTase, orotate phosphoribosyl pyrophosphate transferase, orotate phosphoribosyl transferase, orotate phosphoribosyltransferase, orotate PRTase, orotic acid phosphoribosyltransferase, orotidine 5'-monophosphate pyrophosphorylase, orotidine 5'-phosphate pyrophosphorylase, orotidine monophosphate pyrophosphorylase, orotidine phosphoribosyltransferase, orotidine-5'-phosphate pyrophosphorylase, orotidylate phosphoribosyltransferase, orotidylate pyrophosphorylase, orotidylic acid phosphorylase, orotidylic acid pyrophosphorylase, orotidylic phosphorylase, orotidylic pyrophosphorylase, phosphoribosyltransferase, orotate, Pyr5, PyrE, rv0382c, type I phosphoribosyltransferase, ura5

ECTree

     2 Transferases

         2.4 Glycosyltransferases

             2.4.2 Pentosyltransferases

                2.4.2.10 orotate phosphoribosyltransferase

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Results	in table
1	Activating Compound
44599	AA Sequence
10	Application
1	CAS Registry Number
28	Cloned(Commentary)
9	Crystallization (Commentary)
1113	Disease/ Diagnostics
6	Expression
4	General Information
9	General Stability
136	Inhibitors
18	kcat/KM [mM/s]
93	Ki Value [mM]
93	KM Value [mM]
12	Localization
40	Metals/Ions
35	Molecular Weight [Da]
36	Natural Substrates/ Products (Substrates)
94	Organism
8	Pathway
108	PDB ID
15	pH Optimum
4	pH Range
2	pH Stability
2	pI Value
12	Protein Variants
31	Purification (Commentary)
8	Reaction
1	Reaction Type
91	Reference
52	Source Tissue
30	Specific Activity [micromol/min/mg]
11	Storage Stability
103	Substrates and Products (Substrate)
28	Subunits
98	Synonyms
1	Systematic Name
12	Temperature Optimum [°C]
3	Temperature Stability [°C]
29	Turnover Number [1/s]

General Information

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General Information on EC 2.4.2.10 - orotate phosphoribosyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Plasmodium falciparum

Q8N0R1

fusion of the last two enzymes in the pyrimidine biosynthetic pathway in the inversed order by having a C-terminal orotate phosphoribosyltransferase (OPRT) and an N-terminal orotidine 5'-monophosphate decarboxylase (OMPDC), as OMPDC-OPRT, are described in many organisms. During evolution a gene fusion (i.e., the new gene coding for hybrid protein) is the immediate form between a stand-alone gene of a monofunctional enzyme and a gene fission of multienzyme complex (i.e., single gene from multiple smaller coding segments) responsible for protein-protein interaction, in response to different allosteric controls

748831

malfunction

Homo sapiens

-

decreased activity of OPRT plays an important role in the acquired resistance of gastric cancer cells towards 5-fluorouracil. OPRT-knockout MKN-45 parent cells using small interfering RNA demonstrate 15.8fold increased resistance to 5-fluorouracil compared to the control cell

706023

physiological function

2 entries

physiological function

Pyricularia oryzae

G4MT58

the enzyme is required for mycelial growth, appressorial turgor pressure and penetration into plant tissues, invasive hyphal growth, and pathogenicity

735519

physiological function

Pyricularia oryzae ATCC MYA-4617

-

the enzyme is required for mycelial growth, appressorial turgor pressure and penetration into plant tissues, invasive hyphal growth, and pathogenicity

-