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2.4.2.1: purine-nucleoside phosphorylase

This is an abbreviated version!
For detailed information about purine-nucleoside phosphorylase, go to the full flat file.

Word Map on EC 2.4.2.1

Reaction

purine 2'-deoxyribonucleoside
+
phosphate
=
purine
 +
2-deoxy-alpha-D-ribose 1-phosphate

Synonyms

5'-deoxy-5'-methylthioadenosine phosphorylase II, 5'-methythioadenosine phosphorylase, adenine nucleoside phosphorylase, adenosine phosphorylase, AgPNP, AmPNP, ANP, ApMTAP, apPNP, bovPNP, bPNO, CKP1, cytokinin riboside phosphorylase, DeoD, deoD_1, DgPNP, EC592_06680, EcPNP, flB, GsPNPI, GsPNPII, GtPNP, hPNP, HpPNP, HsPNO, HsPNP, Ino-Guo phosphorylase, inosine phosphorylase, inosine-guanosine phosphorylase, KlacPNP, KLLA0_C16621g, MTAPII, MtbPNP, nucleotide phosphatase (2.4.2.1), PfPNP, phosphorylase, purine nucleoside, PiPNP, PNP, PNP 1, PNP 2, PNP I, PNP II, PNP-II, PNP-Zg, PNPase, pNPI, PNPII, Pu-NPase, punA, PUNP, PUNPI, PUNPII, purine deoxynucleoside phosphorylase, purine deoxyribonucleoside phosphorylase, purine nucleoside orthophosphate ribosyl transferase, purine nucleoside phosphorylase, purine nucleoside phosphorylase 1, purine nucleoside phosphorylase 2, purine nucleoside phosphorylase DeoD, purine nucleoside phosphorylase DeoD-type, purine nucleoside phosphorylase II, purine ribonucleoside phosphorylase, purine-nucleoside phosphorylases II, SalT, SSO2343, TgPNP, TTC0194, TTC1070, TtPNPI, TtPNPII, TvPNP, xanthosine phosphorylase, XAP, xapA, ylmD

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.1 purine-nucleoside phosphorylase

KM Value

KM Value on EC 2.4.2.1 - purine-nucleoside phosphorylase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.022
1-Methylguanosine
-
-
0.05
1-methylinosine
-
-
0.391 - 14.9
2',3'-dideoxyinosine
0.19
2'-deoxyadenosine
-
-
0.015 - 1.9
2'-deoxyguanosine
0.043 - 2.06
2'-deoxyinosine
0.035 - 0.2
2,6-diamino-8-azapurine
0.013
2-amino-6-mercapto-7-methylpurine
-
0.029 - 0.1425
2-amino-6-mercapto-7-methylpurine ribonucleoside
0.023 - 0.264
2-fluoro-2'-deoxyadenosine
0.012
2-fluoroadenosine
pH 7.4, 25°C
0.15 - 0.8
3-(beta-D-ribofuranosyl)adenine
0.22 - 0.26
3-(beta-D-ribofuranosyl)hypoxanthine
0.0106 - 0.0319
5'-methylthioadenosine
0.0088 - 0.06
5'-methylthioinosine
0.167
6-mercaptoguanosine
-
-
0.07
6-mercaptopurine riboside
-
-
0.065
7,8-dimethylguanosine
-
-
0.027 - 0.108
7-(beta-D-ribofuranosyl)guanine
0.64 - 1.52
7-(beta-D-ribofuranosyl)hypoxanthine
0.034
7-butylguanosine
-
-
0.013
7-ethylguanosine
-
-
0.069
7-isopropylguanine
-
-
0.358
7-methyl-6-thio-guanosine
-
pH 7.6
0.0147 - 39.3
7-methylguanosine
0.033 - 0.6
7-Methylinosine
0.012 - 0.08
7-N-methyl-6-thiopurine riboside
0.025
7-prolylguanosine
-
-
0.09 - 0.7
8-Azaguanine
0.661
8-Azahypoxanthine
-
0.1
8-methylguanosine
-
-
0.126
9-beta-D-(2-deoxyribofuranosyl)-6-methylthiopurine
pH 7.4, 25°C
0.009
9-beta-D-ribofuranosyl-6-methylthiopurine
pH 7.4, 25°C
0.34 - 12.3
adenine
0.0061 - 6.1
adenosine
0.1 - 0.133
alpha-D-deoxyribose 1-phosphate
0.04 - 0.228
alpha-D-ribose 1-phosphate
0.63 - 1.8
arsenate
0.145
deoxyadenosine
-
-
0.02 - 0.35
deoxyguanosine
0.027 - 0.67
deoxyinosine
0.1
deoxyribose 1-phosphate
-
reaction with adenine
0.006 - 35.9
guanine
0.0041 - 59.7
guanosine
0.0033 - 45.6
hypoxanthine
0.00001 - 143.1
Inosine
0.09
isobutylguanosine
-
-
0.005 - 0.016
Methylthioinosine
0.05 - 0.08
N7-D-ribosyl-2,6-diamino-8-azapurine
0.007
N8-D-ribosyl-2,6-diamino-8-azapurine
pH 6.5, 25°C, recombinant wild-type enzyme
0.02
N9-D-ribosyl-2,6-diamino-8-azapurine
about, pH 6.5, 25°C, recombinant wild-type enzyme
0.62 - 1.48
nicotinamide riboside
0.09
p-nitrophenyl beta-D-ribofuranoside
0.0031 - 91
phosphate
0.5
ribose 1-phosphate
-
-
0.085 - 0.115
uridine
0.28 - 0.425
xanthine
0.051 - 1.6
Xanthosine
additional information
additional information
-