2.4.1.B62: small GTPase glucosyltransferase
This is an abbreviated version!
For detailed information about small GTPase glucosyltransferase, go to the full flat file.
Reaction
Synonyms
Clostridium sordellii lethal toxin, cytotoxin B, cytotoxin L, glucosyltransferase TcdA, glucosyltransferase TcdB, haemorrhagic toxin, hemorrhagic toxin, letal toxin, lethal toxin, lethal-toxin, TcdA, TcdB, TcsH, TcsL, toxA, ToxB, toxin, toxin A, toxin B
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 2.4.1.B62 - small GTPase glucosyltransferase
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REACTION DIAGRAM
UDP-alpha-D-glucose + murine Rho GTPase
UDP + D-glucosyl-[murine Rho GTPase]
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-
-
?
UDP-alpha-D-glucose + Ras GTPase
UDP + D-glucosyl-[Ras GTPase]
murine host substrate
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-
?
additional information
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enzyme glucosylates and inactivates small GTPases of the Rho or Ras families, culminating in cytotoxicity
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-
?
UDP + D-glucosyl-[a small GTPase]
-
-
-
?
UDP-alpha-D-glucose + a small GTPase
UDP + D-glucosyl-[a small GTPase]
-
-
-
?
UDP-alpha-D-glucose + a small GTPase
UDP + D-glucosyl-[a small GTPase]
Clostridioides difficile 10463
-
-
-
?
UDP-alpha-D-glucose + a small GTPase
UDP + D-glucosyl-[a small GTPase]
-
-
-
?
UDP-alpha-D-glucose + a small GTPase
UDP + D-glucosyl-[a small GTPase]
-
-
-
-
?
UDP-alpha-D-glucose + a small GTPase
UDP + D-glucosyl-[a small GTPase]
-
-
-
?
UDP-alpha-D-glucose + a small GTPase
UDP + D-glucosyl-[a small GTPase]
Paeniclostridium sordellii JGS6382
-
-
-
?
UDP-alpha-D-glucose + H-Ras
UDP + D-glucosyl-H-Ras
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-
-
?
UDP + D-glucosyl-[human Ras-GTPase]
activity of toxin A in human epithelial colorectal adenocarcinoma Caco-2 cells
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-
?
UDP-alpha-D-glucose + human Ras-GTPase
UDP + D-glucosyl-[human Ras-GTPase]
Clostridioides difficile 10463
activity of toxin A in human epithelial colorectal adenocarcinoma Caco-2 cells
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-
?
UDP-alpha-D-glucose + human Ras-GTPase
UDP + D-glucosyl-[human Ras-GTPase]
activity of toxin TcsL in human epithelial colorectal adenocarcinoma Caco-2 cells
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-
?
UDP-alpha-D-glucose + human Ras-GTPase
UDP + D-glucosyl-[human Ras-GTPase]
activity of toxin TcsL in human epithelial colorectal adenocarcinoma Caco-2 cells
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-
?
UDP + D-glucosyl-[Rac GTPase]
murine host substrate
-
-
?
UDP-alpha-D-glucose + Rac GTPase
UDP + D-glucosyl-[Rac GTPase]
Paeniclostridium sordellii JGS6382
murine host substrate
-
-
?
UDP + D-glucosyl-[Rac1 GTPase]
murine host substrate
-
-
?
UDP-alpha-D-glucose + Rac1 GTPase
UDP + D-glucosyl-[Rac1 GTPase]
Paeniclostridium sordellii JGS6382
murine host substrate
-
-
?
UDP + D-glucosyl-[Ral GTPase]
murine host substrate
-
-
?
UDP-alpha-D-glucose + Ral GTPase
UDP + D-glucosyl-[Ral GTPase]
Paeniclostridium sordellii JGS6382
murine host substrate
-
-
?
UDP + D-glucosyl-[Rap GTPase]
murine host substrate
-
-
?
UDP-alpha-D-glucose + Rap GTPase
UDP + D-glucosyl-[Rap GTPase]
Paeniclostridium sordellii JGS6382
murine host substrate
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-
?
UDP + D-glucosyl-Rap2A
modification occurs in vitro and in cells
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-
?
UDP-alpha-D-glucose + Rap2A
UDP + D-glucosyl-Rap2A
modification occurs in vitro and in cells
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-
?
UDP-alpha-D-glucose + RhoA
UDP + D-glucosyl-RhoA
no substrate for wild-type. Mutation S385/A387Q reverses the donor specificity of alpha-toxin from UDP-N-acetylglucosamine to UDP-glucose
-
-
?
UDP-alpha-D-glucose + RhoA
UDP + D-glucosyl-RhoA
no substrate for wild-type. Mutation S385/A387Q reverses the donor specificity of alpha-toxin from UDP-N-acetylglucosamine to UDP-glucose
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-
?