2.4.1.92: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase This is an abbreviated version! For detailed information about (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase, go to the full flat file .
Reaction
UDP-N-acetyl-alpha-D-galactosamine +
O-(N-acetyl-alpha-neuraminyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide =
UDP +
O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1->4)-O-[N-acetyl-alpha-neuraminyl-(2->3)]-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl-(1<->1)-ceramide
Synonyms acetylgalactosaminyltransferase, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-ganglioside GM3, beta 1,4-N-acetylgalactosaminyltransferase-A, beta-(1-4)-N-acetylgalactosaminyltransferase, beta-(1->4)-N-acetylgalactosaminyltransferase, beta-1,4 N-acetylgalactosaminyltransferase 1, beta-1,4-N-acetyl-galactosaminyltransferase 1, beta-1,4-N-acetylgalactosaminyl-transferase, beta-1,4-N-acetylgalactosyltransferase II, beta1,4-N-acetylgalactosaminyltransferase, beta4GalNAc-T1, beta4GalNAcT, beta4GalNAcT-I, beta4GalNAcT-II, beta4GalNAcTA, betaGalNAc-T4, CgtA, CJL-30, GA2 synthase, GA2/GM2/GD2/GT2-synthase, GALGT, Galgt1, GalNAcT, ganglioside GM2 synthase, ganglioside GM3 acetylgalactosaminyltransferase, GD2 synthase, GD2 synthetase, GD2/GM2 synthase, GM2 synthase, GM2/GD2 synthase, GM2/GD2-synthase, GM2S, GM3 synthase, GM3S, N-acetylgalactosaminyltransferase I, Sda beta-1,4-N-acetylgalactosaminyltransferase II, ST3Gal V, UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide, UDP-2-acetamido-2-deoxy-D-galactose:(N-acetylneuraminyl)-D-galactosyl-D-glucosyl-N-acylsphingosine acetamidodeoxygalactosyl-transferase, UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosaminyltransferase I, uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide, uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase
ECTree
Natural Substrates Products
Natural Substrates Products on EC 2.4.1.92 - (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase
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UDP-N-acetyl-alpha-D-galactosamine + ganglioside GM3
UDP + ganglioside GM2
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UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide
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UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide
UDP + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-[N-acetyl-alpha-neuraminosyl-(2-3)]-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide
UDP-N-acetyl-D-galactosamine + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-[N-acetyl-alpha-neuraminosyl-(2-3)]-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide
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additional information
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UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
relative glycosyltransferase levels involved in determining the ganglioside composition of cells
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UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
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model for ganglioside biosynthesis
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UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
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involved in biosynthesis of gangliosides in brain
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UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide
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ganglioside GM3
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UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide
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ganglioside GM3
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UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide
UDP + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-[N-acetyl-alpha-neuraminosyl-(2-3)]-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide
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UDP-N-acetyl-D-galactosamine + 1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide
UDP + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-[N-acetyl-alpha-neuraminosyl-(2-3)]-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide
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UDP-N-acetyl-D-galactosamine + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-[N-acetyl-alpha-neuraminosyl-(2-3)]-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide
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ganglioside GM2
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UDP-N-acetyl-D-galactosamine + 1-O-[O-2-(acetylamino)-2-deoxy-beta-D-galactopyranosyl-(1-4)-O-[N-acetyl-alpha-neuraminosyl-(2-3)]-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl]-ceramide
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ganglioside GM2
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additional information
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during evolution, beta4Gal-T1 appears as a result of the single amino acid substitution of Tyr or Phe for Leu or Ile in the invertebrate beta4GalNAc-T1, overview
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additional information
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the enzyme synthesizes the LacdiNAc structures, with GalNAcbeta1,4GlcNAc, on several glycoproteins and glycosphingolipids, including N-glycans, O-glycans, and the arthro-series GSLs, GalNAcbeta1,4Glc-NAcbeta1,3Manbeta1,4Glcbeta1Cer, and neutral GSLs, in vitro and in vivo, the GalNAcbeta1,4GlcNAc, i.e. LacdiNAc or LDN, structure is a more common structural feature in invertebrate glycoconjugates when compared with the Galbeta1,4GlcNAc, i.e. LacNAc or LN, structure
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additional information
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during evolution, beta4Gal-T1 appears as a result of the single amino acid substitution of Tyr or Phe for Leu or Ile in the invertebrate beta4GalNAc-T1, overview
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