2.4.1.90: N-acetyllactosamine synthase This is an abbreviated version! For detailed information about N-acetyllactosamine synthase, go to the full flat file .
Reaction
UDP-alpha-D-galactose +
N-acetyl-D-glucosamine =
UDP +
N-acetyllactosamine
Synonyms acetyllactosamine synthetase, B4GALT1, B4GALT3, B4GalT5, beta 1,4 galactosyltransferase I, beta 1,4-galactosyltransferase 1, beta 1,4GalT II, beta 1,4GTI, beta(1,4)-galactosyltransferase, beta(1,4)-GT, beta(1-4)galactosyltransferase, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 1, beta-1,4-galactosyltransferase III, beta-1,4-galactosyltransferase IV, beta-1,4-galactosyltransferase-1, beta-1,4-galactosyltransferase-I, beta-1,4-galactosyltransferase-V, beta-1,4-GalT, beta-1,4-GalT-I, beta-1,4-GalT-V, beta-1,4-GT-IV, beta-1,4-N-acetylgalactosaminyltransferase, beta-N-acetylglucosaminide beta1-4-galactosyltransferase, beta1,4-Gal-transferase T1, beta1,4-galactosyltransferase, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase II, beta1,4-galactosyltransferase V, beta1,4-galactosyltransferase-1, beta1,4-galactosyltransferase-7, beta1,4-galactosyltransferase-I, beta1,4-GT, beta1,4GalT II, beta1,4GalTV, beta1-4-galactosyltransferase, beta1-4GalT, beta4Gal-T, beta4Gal-T1, beta4Gal-T7, beta4GalT, beta4GalT1, betaGALT1, beta[1-4]GalT, EC 2.4.1.98, Gal-T, galactosyltransferase, uridine diphosphogalactose-acetylglucosamine, GalNAcT, GALT, GalT1, GalT7, GalTase, GalTase-I, GTase, Hp1-4GalT, lactosamine synthase, lactosamine synthetase, lactose synthetase A protein, lactosylceramide synthase, More, N-acetyllactosamine synthetase, NAL synthetase, NmLgtB, UDP-beta-1,4-galactosyltransferase, UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 5, UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase, UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase, UDP-galactose-acetylglucosamine galactosyltransferase, UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase, UDP-galactose-N-acetylglucosamine galactosyltransferase, UDP-galactose/N-acetylglucosamine beta1,4 galactosyltransferase, UDP-galactose: N-acetylglucosamine beta 1-4 galactosyltransferase, UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase, UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase, UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase, uridine diphosphogalactose-acetylglucosamine galactosyltransferase
ECTree
Natural Substrates Products
Natural Substrates Products on EC 2.4.1.90 - N-acetyllactosamine synthase
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UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
UDP-galactose + (beta-1,4-galactan)n
UDP + (beta-1,4-galactan)n+1
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enzyme elongates beta-1,4-galactan side chains of rhamnogalacturonan I components of the cell wall pectin
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UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
UDP-galactose + N-acetylglucosamine
UDP + N-acetyllactosamine
UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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additional information
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UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
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UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
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UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
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UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
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UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
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UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
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UDP-alpha-D-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
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UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
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UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
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UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
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synthesis of Galbeta1,4GlcNAc groups in N-linked sugar chains of glycoproteins involved in many physiological functions, e.g. sperm-egg interactions, cell migration, and embryonic development, enzyme expression is highly increased during cycloheximide-induced cell apoptosis in liver carcinoma
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UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
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UDP-galactose + N-acetyl-D-glucosamine
UDP + N-acetyllactosamine
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UDP-galactose + N-acetylglucosamine
UDP + N-acetyllactosamine
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UDP-galactose + N-acetylglucosamine
UDP + N-acetyllactosamine
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UDP-galactose + N-acetylglucosamine
UDP + N-acetyllactosamine
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UDP-galactose + N-acetylglucosamine
UDP + N-acetyllactosamine
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UDP-galactose + N-acetylglucosamine
UDP + N-acetyllactosamine
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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the enzyme facilitates sperm binding to the oocyte zona pellucida
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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enzyme participates in the biosynthesis of the oligosaccharide structures of glycoproteins and glycolipids
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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enzyme functions in the coordinate biosynthesis of complex oligosaccharides, proposed to function in intercellular recognition and/or adhesion
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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biosynthesis of keratan sulfate-like polysaccharides
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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the enzyme may be involved in the synthesis of poly-N-acetyllactosamine, lacto-N-neotetraose and probably lacto-N-neotetraosylceramide in addition to the formation of the Galbeta1-4GlcNAc group of glycoprotein sugar chains and lactose
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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main enzyme responsible for the transfer of galactose residues from UDPgalactose into terminal N-acetylglucosamine residues of complex-type oligosaccharides in newly synthesized glycoproteins in the Golgi apparatus. Deficiency of UDP-galactose:N-acetylglucosamine beta-1,4-galactosyltransferase I causes the congenital disorder of glycosylation type IId, a severe neurologic disease characterized by a hydrocephalus, myopathy and blood-clotting defects
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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the enzyme is involved in the biosynthesis of a variety of carbohydrate structures in glycoproteins and glycolipids
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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biosynthesis of carbohydrate moieties of glycoproteins and glycolipids, role in intercellular recognition and adhesion
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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the soluble enzyme form from the luminal fluid of the epididymis is suggested to play a role on sperm maturation
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UDPgalactose + N-acetylglucosaminyl at the non-reducing ends of protein-bound oligosaccharides
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the enzyme may be involved in the synthesis of plasma glycoproteins by the liver during secretion, and may possibly be required for secretion of these proteins
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additional information
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the enzyme is part of the endoplasmic reticulum and Golgi glycosylation network, glycosyltransferase metabolism, overview
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additional information
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the preexisting alpha-lactalbumin-binding site iss utilized during mammalian evolution to synthesize lactose in the mammary gland during lactation
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additional information
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the enzyme utilizes different glycoproteins and glycolipids as substrates, patients with rheumatoid arthritis have a higher content of an acidic isoform compared to healthy individuals, the isoform is not associated with inflammation per se but specifically with rheumatoid arthritis
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additional information
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tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosis, relationships between tumor beta-1,4-GT-IV overexpression and clinicopathologic characteristics, overview
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additional information
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beta1,4-galactosyltransferase II is one of the enzymes transferring galactose to the terminal N-acetylglucosamine of complex-type N-glycans. Beta1,4GalT II might serve as a target gene of p53 transcription factor during adriamycin-induced HeLa cell apoptosis, mechanisms of its expression regulation, overview
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additional information
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the enzyme is involved in regulation of carbohydrate composition of milk during lactation, endocrine enzyme regulation, overview
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additional information
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the enzyme is one of the key molecules on the sperm surface, and is likely to be involved in binding to the egg coat, the zona pelludica, to mediate sperm-egg interaction
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