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2.4.1.90: N-acetyllactosamine synthase

This is an abbreviated version!
For detailed information about N-acetyllactosamine synthase, go to the full flat file.

Word Map on EC 2.4.1.90

Reaction

UDP-alpha-D-galactose
+
N-acetyl-D-glucosamine
=
UDP
 +
N-acetyllactosamine

Synonyms

acetyllactosamine synthetase, B4GALT1, B4GALT3, B4GalT5, beta 1,4 galactosyltransferase I, beta 1,4-galactosyltransferase 1, beta 1,4GalT II, beta 1,4GTI, beta(1,4)-galactosyltransferase, beta(1,4)-GT, beta(1-4)galactosyltransferase, beta-1,4-galactosyltransferase, beta-1,4-galactosyltransferase 1, beta-1,4-galactosyltransferase III, beta-1,4-galactosyltransferase IV, beta-1,4-galactosyltransferase-1, beta-1,4-galactosyltransferase-I, beta-1,4-galactosyltransferase-V, beta-1,4-GalT, beta-1,4-GalT-I, beta-1,4-GalT-V, beta-1,4-GT-IV, beta-1,4-N-acetylgalactosaminyltransferase, beta-N-acetylglucosaminide beta1-4-galactosyltransferase, beta1,4-Gal-transferase T1, beta1,4-galactosyltransferase, beta1,4-galactosyltransferase I, beta1,4-galactosyltransferase II, beta1,4-galactosyltransferase V, beta1,4-galactosyltransferase-1, beta1,4-galactosyltransferase-7, beta1,4-galactosyltransferase-I, beta1,4-GT, beta1,4GalT II, beta1,4GalTV, beta1-4-galactosyltransferase, beta1-4GalT, beta4Gal-T, beta4Gal-T1, beta4Gal-T7, beta4GalT, beta4GalT1, betaGALT1, beta[1-4]GalT, EC 2.4.1.98, Gal-T, galactosyltransferase, uridine diphosphogalactose-acetylglucosamine, GalNAcT, GALT, GalT1, GalT7, GalTase, GalTase-I, GTase, Hp1-4GalT, lactosamine synthase, lactosamine synthetase, lactose synthetase A protein, lactosylceramide synthase, More, N-acetyllactosamine synthetase, NAL synthetase, NmLgtB, UDP-beta-1,4-galactosyltransferase, UDP-Gal:betaGlcNAc beta-1,4-galactosyltransferase, polypeptide 5, UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase, UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase, UDP-galactose-acetylglucosamine galactosyltransferase, UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase, UDP-galactose-N-acetylglucosamine galactosyltransferase, UDP-galactose/N-acetylglucosamine beta1,4 galactosyltransferase, UDP-galactose: N-acetylglucosamine beta 1-4 galactosyltransferase, UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase, UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase, UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase, uridine diphosphogalactose-acetylglucosamine galactosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.90 N-acetyllactosamine synthase

Crystallization

Crystallization on EC 2.4.1.90 - N-acetyllactosamine synthase

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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
catalytic enzyme domain without complexed substrate, conf-I' conformation, X-ray diffraction structure determination and analysis at 1.9 A resolution
-
crystal structure of enzyme-alpha-lactalbumin complex with UDP-Glc
-
crystal structures of the beta4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose
-
M344H mutant enzyme complexed with UDP-Gal and Mn2+ or Mg2+, hanging drop vapour diffusion method, 30 mg/ml protein in solution with 17 mM UDP-Gal, and 17 mM MgCl2 or MnCl2, precipitated by 10% v/v dioxane, 100 mM MES-NaOH, pH 6.5, and 2.0M ammonium sulfate, room temperature, X-ray diffraction structure determination and analysis at 2.3 A resolution, determination of conformation stereochemistry, modeling
-
mutant enzyme C342T/M344H, hanging drop vapor diffusion method, using 100 mM MES-NaOH buffer pH 6.5, 1.8 M ammonium sulfate and 10% (v/v) 1, 4-dioxane
recombinant enzyme, crystal structure of lactose synthase reveals a large conformational change in its catalytic component, the beta1,4-galactosyltransferase-I
-
crystal structure of the catalytic domain of beta4Gal-T7 from Drosophila melanogaster in the presence of manganese and UDP at 1.81 A resolution is shown. In the crystal structure, a new manganese ion-binding motif is observed. Superposition of the crystal structures of beta4Gal-T7 and beta4Gal-T1 shows that the catalytic pocket and the substrate-binding sites in these proteins are similar
-
enzyme in complex with Mn2+, UDP-GalNAc, glucose, and alpha-lactalbumin, X-ray diffraction structure determination and analysis at 2.0 A resolution
-
hanging drop vapor diffusion method, using 0.2 M potassium nitrate, 20% (w/v) PEG 3350
-
W314A enzyme mutant complexed with alpha-lactalbumin in presence of N-acetylglucoamine, UDP, and Mn2+, conf-II conformation, X-ray diffraction structure determination and analysis at 2.3 A resolution
-