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2.4.1.80: ceramide glucosyltransferase

This is an abbreviated version!
For detailed information about ceramide glucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.80

Reaction

UDP-alpha-D-glucose
+
an N-acylsphingosine
=
UDP
 +
a beta-D-glucosyl-N-acylsphingosine

Synonyms

ceramide glucosyltransferase, ceramide glycosyltransferase, ceramide:UDP-glucose glucosyltransferase, ceramide:UDPGlc glucosyltransferase, cerebroside synthase, CGT, cgt-1, cgt-2, cgt-3, GCS, GCS1, GlcCer synthase, GlcCerS, GlcT, GlcT-1, glucosylceramide synthase, glucosyltransferase, uridine diphosphoglucose-ceramide, GluT, UDP glucose-ceramide glucosyltransferase, UDP-Glc:ceramide glucosyltransferase, UDP-glucoase:ceramide glucosyltransferase, UDP-glucose ceramide glucosyltransferase, UDP-glucose ceramide glycosyltransferase, UDP-glucose: ceramide glucosyltransferase, UDP-glucose:ceramide glucosyltransferase, Ugcg, uridine diphosphate (UDP)-glucose:N-acylsphingosine D-glucosyltransferase, uridine diphosphoglucose-ceramide glucosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.80 ceramide glucosyltransferase

Disease

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Disease on EC 2.4.1.80 - ceramide glucosyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells.
ceramide glucosyltransferase deficiency
Identification of a novel lethal form of autosomal recessive ichthyosis caused by UDP-glucose ceramide glucosyltransferase deficiency.
Gaucher Disease
A novel method for preparing Eligulstat through chiral resolution.
Glucosylated cholesterol in mammalian cells and tissues: formation and degradation by multiple cellular ?-glucosidases.
Glucosylceramide modulates endolysosomal pH in Gaucher disease.
Miglustat.
The sirtuin inhibitor cambinol reduces intracellular glucosylceramide with ceramide accumulation by inhibiting glucosylceramide synthase.
Ichthyosis
Identification of a novel lethal form of autosomal recessive ichthyosis caused by UDP-glucose ceramide glucosyltransferase deficiency.
Infections
Regulation of sphingolipid and glycosphingolipid metabolism in extrahepatic tissues by endotoxin.
Lysosomal Storage Diseases
Glucosylceramide mimics: highly potent GCase inhibitors and selective pharmacological chaperones for mutations associated with types?1 and 2 Gaucher disease.
Melanoma
Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death.
Role of lipids in the retrograde pathway of ricin intoxication.
Melanoma, Experimental
Expression machinery of GM4: the excess amounts of GM3/GM4S synthase (ST3GAL5) are necessary for GM4 synthesis in mammalian cells.
Homeostasis of cell-surface glycosphingolipid content in B16 melanoma cells. Evidence revealed by an endoglycoceramidase.
Novel sterol glucosyltransferase in the animal tissue and cultured cells: Evidence that glucosylceramide as glucose donor.
Mucopolysaccharidosis III
N-butyldeoxynojirimycin treatment restores the innate fear response and improves learning in mucopolysaccharidosis IIIA mice.
Neoplasms
DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells.
Regulation of glycosphingolipid metabolism in liver during the acute phase response.
Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth.
Neuroblastoma
Effects of an inhibitor of glucosylceramide synthase on glycosphingolipid synthesis and neurite outgrowth in murine neuroblastoma cell lines.
Obesity
Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.
Parkinson Disease
Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons.
The sirtuin inhibitor cambinol reduces intracellular glucosylceramide with ceramide accumulation by inhibiting glucosylceramide synthase.
Pruritus
The relationship between dermatological findings and serum interleukin 31 and serum uridine diphosphate glucose ceramide glucosyltransferase levels among patients with chronic kidney disease.
Renal Insufficiency, Chronic
The relationship between dermatological findings and serum interleukin 31 and serum uridine diphosphate glucose ceramide glucosyltransferase levels among patients with chronic kidney disease.