2.4.1.80: ceramide glucosyltransferase

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For detailed information about ceramide glucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.80

2.4.1.80

glucosylceramide

glycosphingolipids

sphingolipids

gangliosides

gm3

sphingoid

galactosylceramide

d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol

gaucher

d-pdmp

n-butyldeoxynojirimycin

nb-dnj

1-phenyl-2-decanoylamino-3-morpholino-1-propanol

galcers

medicine

udp-galactose:ceramide

glucocerebroside

cgalt

laccer

conduritol

pharmacology

molecular biology

drug development

Reaction

Synonyms

ceramide glucosyltransferase, ceramide glycosyltransferase, ceramide:UDP-glucose glucosyltransferase, ceramide:UDPGlc glucosyltransferase, cerebroside synthase, CGT, cgt-1, cgt-2, cgt-3, GCS, GCS1, GlcCer synthase, GlcCerS, GlcT, GlcT-1, glucosylceramide synthase, glucosyltransferase, uridine diphosphoglucose-ceramide, GluT, UDP glucose-ceramide glucosyltransferase, UDP-Glc:ceramide glucosyltransferase, UDP-glucoase:ceramide glucosyltransferase, UDP-glucose ceramide glucosyltransferase, UDP-glucose ceramide glycosyltransferase, UDP-glucose: ceramide glucosyltransferase, UDP-glucose:ceramide glucosyltransferase, Ugcg, uridine diphosphate (UDP)-glucose:N-acylsphingosine D-glucosyltransferase, uridine diphosphoglucose-ceramide glucosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.80 ceramide glucosyltransferase

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Results	in table
24	Activating Compound
3411	AA Sequence
12	Application
1	CAS Registry Number
26	Cloned(Commentary)
64	Disease/ Diagnostics
11	Expression
18	General Information
5	General Stability
135	IC50 Value
208	Inhibitors
1	Ki Value [mM]
13	KM Value [mM]
37	Localization
27	Metals/Ions
27	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
419	Organism
7	Pathway
28	pH Optimum
1	pH Range
36	Protein Variants
9	Purification (Commentary)
4	Reaction
1	Reaction Type
90	Reference
2	Renatured (Commentary)
104	Source Tissue
30	Specific Activity [micromol/min/mg]
3	Storage Stability
152	Substrates and Products (Substrate)
8	Subunits
133	Synonyms
1	Systematic Name
25	Temperature Optimum [°C]
1	Temperature Range [°C]

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Application on EC 2.4.1.80 - ceramide glucosyltransferase

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drug development

Homo sapiens

Q16739

the enzyme is an attractive target for drug development both in relation to lysosomal storage disorders (in particular Gaucher disease) and type2 diabetes

735962

medicine

9 entries

molecular biology

Fusarium graminearum

glucosylceramide is essential for MsDef1-mediated growth inhibition of Fusarium graminearum, but not for its pathogenicity

694220

pharmacology

Plasmodium falciparum

enzyme might be an attractive target for malarial chemotherapy

658636