2.4.1.79: globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

This is an abbreviated version!
For detailed information about globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase, go to the full flat file.

Word Map on EC 2.4.1.79

2.4.1.79

ganglioside

retina

triton

gm3

chicken

forssman

synthesis

glycosphingolipids

udp-galnac

glycolipid

Reaction

alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Synonyms

acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide, acetylgalactosaminyltransferase, uridine diphosphoacetylgalactosamine-glycosphingolipid, beta(1->3) N-acetylgalactosaminyltransferase, beta1,3GalNAc-T, EC 2.4.1.154, galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase, GalNAc transferase, globoside N-acetylgalactosaminyltransferase, globoside synthetase, glycosphingolipid beta-N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase, UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.79 globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

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Results	in table
10	Activating Compound
6	AA Sequence
3	Application
2	CAS Registry Number
1	Cloned(Commentary)
2	General Stability
14	Inhibitors
8	KM Value [mM]
5	Localization
11	Metals/Ions
3	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
16	Organism
4	Pathway
5	pH Optimum
1	pH Range
1	Posttranslational Modification
1	Protein Variants
3	Purification (Commentary)
1	Reaction
1	Reaction Type
11	Reference
20	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
27	Substrates and Products (Substrate)
2	Subunits
12	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 2.4.1.79 - globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

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4-hydroxymercuribenzoate

Canis lupus familiaris

0.5 mM, complete inhibition

489384

EDTA

3 entries

Globotetraosylceramide

GSH

2 mM, 17% inhibition

II3-alpha-N-Acetylneuraminyl-lactosylceramide

Mesocricetus auratus

488622

iodoacetamide

Canis lupus familiaris

1 mM, 65% inhibition

489384

iodoacetic acid

Canis lupus familiaris

1 mM, 91% inhibition

489384

NaN3

Cavia porcellus

2 mM, 38% inhibition

489381

NEM

Canis lupus familiaris

1 mM, 67% inhibition

489384

sodium deoxycholate

Cavia porcellus

489381

UDP

Canis lupus familiaris

competitive to UDP-N-acetylgalactosamine, non-competitive to globotriaosylceramide

489384

additional information

Mesocricetus auratus

no effect: lactosylceramide

488622