2.4.1.69: type 1 galactoside alpha-(1,2)-fucosyltransferase

This is an abbreviated version!
For detailed information about type 1 galactoside alpha-(1,2)-fucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.69

2.4.1.69

fucosylation

oligosaccharide

sialylated

glycans

glycosyltransferases

epitope

lectin

sialyltransferase

glycolipids

selectins

glycoconjugates

histo-blood

n-acetylglucosaminyltransferase

fucts

e-selectin

nonsecretors

sialyl-lewis

asialofetuin

alpha-l-fucosidase

xyloglucan

lewisa

hyperacute

fucosidase

2'-fucosyllactose

n-acetyllactosamine

h-type

bombay

lactosamine

xenoreactive

psgl-1

fucose-containing

fuct-vii

analysis

difucosylated

gnt-iii

hbgas

alpha1-6

medicine

noroviruses

1-3glcnac

xenoantigens

xylosyltransferase

glycomic

lacnac

synthesis

neuac

alpha-gal

alpha1,3-galactosyltransferase

tamarind

lacto-n-biose

Reaction

GDP-beta-L-fucose

+

beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R

=

GDP

+

alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R

Synonyms

a-(1->/2)-L-GalT, alpha (1,2)fucosyltransferase, alpha (1,2)fucosyltransferase 2, alpha (1,2)fucosyltransferase I, alpha 1, 2-fucosyltransferase 1, alpha(1,2)-fucosyltransferase, alpha(1,2)-fucosyltransferase-I, alpha(1,2)fucosyltransferase, alpha(1,2)fucosyltransferase I, alpha-(1,2)-fucosyltransferase, alpha-(1->/2)-L-galactosyltransferase, alpha-(1->2)-L-fucosyltransferase, alpha-1,2-fucosyltransferase, alpha-2-fucosyltransferase, alpha-2-L-fucosyltransferase, alpha-L-fucosyltransferase, alpha1,2-FT, alpha1,2-fucosyltransferase, alpha1,2-FucT, alpha1,2FT, alpha1,2fucosyltransferase, alpha1-2FucT, alpha1->2-fucosyltransferase, alpha1->2-FucT, alpha2-fucosyltransferase, alpha2FT, At2g03220, beta-galactoside alpha1-2fucosyltransferase, blood group H alpha-2-fucosyltransferase, blood-group substance H-dependent fucosyltransferase, CE2FT-2, EC 2.4.1.89, FTA, Ftb, fucosyltransferase, fucosyltransferase 1, fucosyltransferase 2, fucosyltransferase, guanosine diphosphofucose-galactoside 2-L-, fucosyltransferase, guanosine diphosphofucose-glycoprotein 2-alpha-, fucosyltransferase, guanosine diphosphofucose-lactose, FucT, FUT1, FUT2, FUT4, FUT4.1, FUT6, futC, galactoside 2-alpha-L-fucosyltransferase, galactoside 2-alpha-L-fucosyltransferase 1, galactoside 2-alpha-L-fucosyltransferase 2, GDP fucose-lactose fucosyltransferase, GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase, GDP-fucose:GM1 alpha1-2fucosyltransferase, GDP-L-fucose:beta-D-galactosyl-R-alpha-L-fucosyltransferase, GDP-L-fucose:lactose fucosyltransferase, GDPFuc:beta-D-galactoside alpha1,2-fucosyltransferase, guanosine diphospho-L-fucose-lactose fucosyltransferase, guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase, guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase, guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase, H gene-encoded beta-galactoside alpha1->2 fucosyltransferase, H-gene-encoded beta-galactoside alpha1-2fucosyltransferase, MFUT-I, MFUT-II, pgtA, Se gene-encoded beta-galactoside alpha1->2 fucosyltransferase, Sec1, secretor-type beta-galactoside alpha1-2fucosyltransferase, WbgL, WbiQ, WbsJ, wbwK, WcfB

ECTree

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.69 type 1 galactoside alpha-(1,2)-fucosyltransferase

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Results	in table
17	Activating Compound
173	AA Sequence
13	Application
1	CAS Registry Number
24	Cloned(Commentary)
708	Disease/ Diagnostics
3	Expression
25	General Information
1	General Stability
45	Inhibitors
5	kcat/KM [mM/s]
5	Ki Value [mM]
131	KM Value [mM]
14	Localization
39	Metals/Ions
24	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
113	Organism
6	Pathway
16	PDB ID
18	pH Optimum
3	pH Range
1	pI Value
1	Posttranslational Modification
20	Protein Variants
14	Purification (Commentary)
2	Reaction
1	Reaction Type
93	Reference
99	Source Tissue
11	Specific Activity [micromol/min/mg]
3	Storage Stability
231	Substrates and Products (Substrate)
22	Subunits
246	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Range [°C]
2	Temperature Stability [°C]
9	Turnover Number [1/s]

KM Value

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KM Value on EC 2.4.1.69 - type 1 galactoside alpha-(1,2)-fucosyltransferase

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0.45

6-sulfoGalbeta(1-4)GlcNAcbeta-O-methyl

-

-

2.9 - 24

beta-D-galactose

show

3.2 - 8.5

beta-D-galactose-beta-O-2-(2-carbomethoxyethylthio)ethyl

show

3.8 - 11.1

beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosamine

show

7.1 - 8.3

beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosamine

show

0.95 - 4.5

beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine

show

1

bovine IgG diantennary glycopeptide

-

-

-

5.3

D-lactose

Escherichia coli

at pH 7.6 and 30°C

33

di-N-acetylchitobiose

-

-

0.5

fetuin triantennary asialoglycopeptide

-

-

-

3.8 - 11.1

galacto-N-biose

show

1.5

Galalpha(1-3)Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc-ceramide

-

-

66

GalalphaCH3

-

-

14.6

Galbeta(1-3)Ara

-

-

0.28 - 20

Galbeta(1-3)GalNAc

show

0.61

Galbeta(1-3)GalNAcalpha-O-p-nitrophenol

Caenorhabditis elegans

-

-

12

Galbeta(1-3)GalNAcbeta1-OCH2CH=CH2

Lymnaea stagnalis

-

-

0.63

Galbeta(1-3)GlcNAc

-

-

0.17

Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc

-

-

1.6

Galbeta(1-3)GlcNAcbeta(1-3)Galbeta(1-4)Glc-beta-O-PA8

-

H-gene encoded enzyme

0.31

Galbeta(1-3)GlcNAcbeta-O-allyl/acrylamide copolymer

-

-

-

0.83

Galbeta(1-3)GlcNAcbeta-O-benzyl

-

-

2.9 - 3.1

Galbeta(1-4)Glc-beta-O-2-(2-carbomethoxyethylthio)ethyl

show

2.11

Galbeta(1-4)GlcNAc

-

-

2.5

Galbeta(1-4)GlcNAc-beta-O-2-(2-carbomethoxyethylthio)ethyl

-

H-endoced and Se-encoded enzyme

0.6

Galbeta(1-4)GlcNAcbeta(1-3)Galbeta(1-4)Glc-ceramide

-

-

0.94

Galbeta(1-4)GlcNAcbeta(1-3)Galbeta1-4Glc

-

-

1.67

Galbeta(1-4)GlcNAcbeta-O-benzyl

-

-

1.95

Galbeta(1-6)GalNAc

-

-

2.56

Galbeta(1-6)GlcNAc

-

-

0.82

Galbeta-O-benzyl

-

-

59.62

Galbeta-O-Me

Escherichia coli

-

wild-type

10.7

Galbeta1-4Glc

-

-

4.2

Galbeta1-6GalNAc

-

H-gene encoded enzyme

18

GalbetaCH3

-

-

0.024 - 1.997

GDP-beta-L-fucose

show

0.05 - 0.178

GDP-fucose

show

0.0011 - 1.54

GDP-L-fucose

show

0.082 - 0.11

GM1

show

5.6 - 8.3

lacto-N-biose

show

1.4 - 3.5

lacto-N-biose I

show

3.4 - 5.5

lacto-N-neotetraose

show

1.4 - 2.2

lacto-N-tetraose

show

2.1 - 8.9

lactose

show

4.9

lactose-N-biose I

-

enzyme from plasma

0.052 - 0.068

lactosylceramide

show

13.26 - 108

lactulose

show

1.1 - 14.3

N-acetyl-beta-lactosamine

show

5.2 - 20

N-acetyllactosamine

show

33

phenyl beta-D-galactopyranoside

Rattus norvegicus

pH 7.2, 37°C

8.2 - 8.79

phenyl beta-D-galactoside

show

25

phenyl beta-galactose

show

3 - 125

phenyl-beta-D-galactoside

show

2.7 - 8.4

phenyl-beta-O-galactoside

show

additional information

additional information

-

KM-value for asialofetuin: 3.33 mg/ml

-

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Release 2023.1 (January 2023)