Any feedback?
Please rate this page
(all_enzymes.php)
(0/150)

BRENDA support

2.4.1.68: glycoprotein 6-alpha-L-fucosyltransferase

This is an abbreviated version!
For detailed information about glycoprotein 6-alpha-L-fucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.68

Reaction

GDP-beta-L-fucose
+
N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein]
=
GDP
 +
N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc]-L-asparaginyl-[protein]

Synonyms

6FucT, alfC, alpha(1,6)FT, alpha(1,6)fucosyltransferase, alpha-1,6-fucosyltransferase, alpha-6-fucosyltransferase, alpha1,6-fucosyltransferase, alpha1,6-FucT, alpha1,6FucT, alpha1-6,fucosyltransferase, alpha1-6FucT, alpha6FucT, BN194_28780, fucosyltransferase 8, fucosyltransferase, guanosine diphosphofucose-glycoprotein, FUT8, GDP-fucose glycoprotein fucosyltransferase, GDP-fucose-glycoprotein fucosyltransferase, GDP-L-fuc:N-acetyl-beta-D-glucosaminide alpha1-6fucosyltransferase, GDP-L-fucose-glycoprotein fucosyltransferase, GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside 6-alpha-L-fucosyltransferase, GDPfucose glycoprotein fucosyltransferase, glycoprotein fucosyltransferase, guanosine diphosphofucose-glycoprotein fucosyltransferase, NodZ, NodZ fucosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.68 glycoprotein 6-alpha-L-fucosyltransferase

Substrates Products

Substrates Products on EC 2.4.1.68 - glycoprotein 6-alpha-L-fucosyltransferase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
GDP-beta-fucose + (N-acetylglucosaminyl)2-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine
GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of (N-acetylglucosaminyl)2-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine
show the reaction diagram
-
-
-
-
?
GDP-beta-fucose + Gal-N-acetylglucosaminyl-Man5-GlcNAc2-(6-biotinamidohexanoyl)asparagine
GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of Gal-N-acetylglucosaminyl-Man5-GlcNAc2-(6-biotinamidohexanoyl)asparagine
show the reaction diagram
-
low activity
-
-
?
GDP-beta-fucose + Gal-N-acetylglucosaminyl-Man5-GlcNAc2-(N-(9-fluorenyl)methoxycarbonyl)asparagine
GDP + L-fucose alpha-1,6 bound to Gal-N-acetylglucosaminyl-Man5-GlcNAc2-(N-(9-fluorenyl)methoxycarbonyl)asparagine
show the reaction diagram
100% yield
-
-
?
GDP-beta-fucose + Gal-N-acetylglucosaminyl-Man5-GlcNAc2-erythropoietin
GDP + L-fucose alpha-1,6 bound to the erythropoitin-linked N-acetylglucosamine of Gal-N-acetylglucosaminyl-Man5 + GDP
show the reaction diagram
-
-
-
?
GDP-beta-fucose + Gal2-(N-acetylglucosaminyl)2-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine
GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of Gal2-(N-acetylglucosaminyl)2-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine
show the reaction diagram
-
low activity
-
-
?
GDP-beta-fucose + Man5-GlcNAc2-(N-(9-fluorenyl)methoxycarbonyl)asparagine
GDP + L-fucose alpha-1,6 bound to Man5-GlcNAc2-(N-(9-fluorenyl)methoxycarbonyl)asparagine
show the reaction diagram
30% yield
-
-
?
GDP-beta-fucose + N-acetylglucosaminyl-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine
GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of N-acetylglucosaminyl-Man3-GlcNAc2-(6-biotinamidohexanoyl)asparagine
show the reaction diagram
-
best substrate
-
-
?
GDP-beta-fucose + N-acetylglucosaminyl-Man5-GlcNAc2-(6-biotinamidohexanoyl)asparagine
GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of N-acetylglucosaminyl-Man5-GlcNAc2-(6-biotinamidohexanoyl)asparagine
show the reaction diagram
-
-
-
-
?
GDP-beta-L-fucose + asialo-agalacto apotransferrin
?
show the reaction diagram
-
-
-
-
?
GDP-beta-L-fucose + Asn-linked agalacto-biantennary sugar chain
?
show the reaction diagram
-
-
-
-
?
GDP-beta-L-fucose + Gal-N-acetylglucosaminyl-Man5-GlcNAc2-HIV-1 V3 glycopeptide
GDP + L-fucose alpha-1,6-bound to Gal-N-acetylglucosaminyl-Man5-GlcNAc2-HIV-1 V3 glycoprotein
show the reaction diagram
100% yield
-
-
?
GDP-beta-L-fucose + Man5-GlcNAc2-erythropoietin
GDP + L-fucose alpha-1,6-bound to Man5-GlcNAc2-erythropoietin
show the reaction diagram
FUT8 is able to core-fucosylate Man5GlcNAc2 glycan in vitro in the context of reythropoietin, lacking an unmodified GlcNAc moiety at the alpha1,3-arm, 90% yield
-
-
?
GDP-beta-L-fucose + Man5-GlcNAc2-HIV-1 V3 glycopeptide
GDP + L-fucose alpha-1,6-bound to Man5-GlcNAc2-HIV-1 V3 glycoprotein
show the reaction diagram
50% yield
-
-
?
GDP-beta-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl]asparagine
show the reaction diagram
GDP-beta-L-fucose + reducing terminal GlcNAc of the core structure of asparagine-linked oligosaccharide
?
show the reaction diagram
-
rapid equilibrium random mechanism
-
-
?
GDP-L-Fuc + asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan
L-fucose alpha-1,6-bound to asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan + GDP
show the reaction diagram
-
-
-
?
GDP-L-fucose + 4-methylumbelliferyl-N,N',N''-triacetyl chitotriose
?
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + 4-nitrophenyl penta-N-acetylchitopentaoside
GDP + ?
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + 4-nitrophenyl tetra-N-acetylchitotetraose
GDP + ?
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + 4-nitrophenyl tri-N-acetylchitotriose
?
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + asialo-agalactofetuin
?
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + asialo-agalactotransferrin glycopeptide
GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of the asialo-agalactotransferrin glycopeptide
show the reaction diagram
GDP-L-fucose + factor VII EGF-1 domain
GDP + L-fucose alpha-1,6 bound to the asparagine-linked N-acetylglucosamine of the factor VII EGF-1 domain
show the reaction diagram
GDP-L-fucose + fibulin-1C
?
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + glucose regulated glycoprotein of 94 kDa
?
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + IgG Fc binding protein
?
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + immunoglobulin alpha-1 constant region
?
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + immunoglobulin G B12 heavy chain
?
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + Man-alpha-(1-6)-[Man-alpha-(1-3)-]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl-asparagine
GDP + Man-alpha-(1-6)-[Man-alpha-(1-3)-]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl-asparagine
show the reaction diagram
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-(N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl)asparagine
show the reaction diagram
alpha1,6-fucosylation, also referred to as core fucosylation, plays an essential role in various pathophysiological events. FUT8 null mice shows severe growth retardation and emphysema-like lung-destruction as a result of the dysfunction of epidermal growth factor and transforming growth factor-beta receptors
-
-
?
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
show the reaction diagram
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine)
show the reaction diagram
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine)
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine-bi-(4-(2-pyridylamino)butylamine)
show the reaction diagram
GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminy]asparagine
GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
show the reaction diagram
GDP-L-fucose + platelet glycoprotein IIIa
?
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + polymeric immunoglobulins receptor
?
show the reaction diagram
-
-
-
-
?
GDP-L-fucose + vascular adhesion protein 1
?
show the reaction diagram
-
-
-
-
?
GDP-L-Gal + asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan
L-galactose bound to asparagine-linked N-acetyl-beta-D-glucosamine of asialo-agalacto-bi-antennary N-glycan + GDP
show the reaction diagram
-
-
-
?
additional information
?
-