2.4.1.68: glycoprotein 6-alpha-L-fucosyltransferase This is an abbreviated version! For detailed information about glycoprotein 6-alpha-L-fucosyltransferase, go to the full flat file .
Word Map on EC 2.4.1.68
Reaction
GDP-beta-L-fucose +
N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein] =
GDP +
N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc]-L-asparaginyl-[protein]
Synonyms 6FucT, alfC, alpha(1,6)FT, alpha(1,6)fucosyltransferase, alpha-1,6-fucosyltransferase, alpha-6-fucosyltransferase, alpha1,6-fucosyltransferase, alpha1,6-FucT, alpha1,6FucT, alpha1-6,fucosyltransferase, alpha1-6FucT, alpha6FucT, BN194_28780, fucosyltransferase 8, fucosyltransferase, guanosine diphosphofucose-glycoprotein, FUT8, GDP-fucose glycoprotein fucosyltransferase, GDP-fucose-glycoprotein fucosyltransferase, GDP-L-fuc:N-acetyl-beta-D-glucosaminide alpha1-6fucosyltransferase, GDP-L-fucose-glycoprotein fucosyltransferase, GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside 6-alpha-L-fucosyltransferase, GDPfucose glycoprotein fucosyltransferase, glycoprotein fucosyltransferase, guanosine diphosphofucose-glycoprotein fucosyltransferase, NodZ, NodZ fucosyltransferase
ECTree
Specific Activity
Specific Activity on EC 2.4.1.68 - glycoprotein 6-alpha-L-fucosyltransferase
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0.00000037
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hepatoma cell line AH-66
0.00000072
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DAB-induced hepatoma cell
0.0000355
recombinant enzyme from COS-1 cells
0.000039
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recombinant enzyme from COS-1 cells
0.0000025
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testis
0.0000025
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hepatoma cell line AH-130
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assay method development
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kinetics
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activity in hepatic disease
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activity in hepatic disease
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lentil lectin-based assay method development
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alpha(1,6)FT activity is considerably higher in colorectal tumour tissue than in healthy tissue and is related to gender, lymph node metastasis, type of growth and tumour stage
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44.1 U/l in HEK-293 cells transfected with epidermal growth factor receptor and FUT8, 1.8 U/l in HEK-293 cells transfected only with epidermal growth factor receptor
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average activity 2.0 U/l
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assay method development
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fluorescent assay method development, structural analysis of the reaction product, kinetics
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fluorescent assay method development, structural analysis of the reaction product, kinetics