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2.4.1.68: glycoprotein 6-alpha-L-fucosyltransferase

This is an abbreviated version!
For detailed information about glycoprotein 6-alpha-L-fucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.68

Reaction

GDP-beta-L-fucose
+
N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc]-L-asparaginyl-[protein]
=
GDP
+
N4-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-[alpha-L-Fuc-(1->6)]-beta-D-GlcNAc]-L-asparaginyl-[protein]

Synonyms

6FucT, alfC, alpha(1,6)FT, alpha(1,6)fucosyltransferase, alpha-1,6-fucosyltransferase, alpha-6-fucosyltransferase, alpha1,6-fucosyltransferase, alpha1,6-FucT, alpha1,6FucT, alpha1-6,fucosyltransferase, alpha1-6FucT, alpha6FucT, BN194_28780, fucosyltransferase 8, fucosyltransferase, guanosine diphosphofucose-glycoprotein, FUT8, GDP-fucose glycoprotein fucosyltransferase, GDP-fucose-glycoprotein fucosyltransferase, GDP-L-fuc:N-acetyl-beta-D-glucosaminide alpha1-6fucosyltransferase, GDP-L-fucose-glycoprotein fucosyltransferase, GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside 6-alpha-L-fucosyltransferase, GDPfucose glycoprotein fucosyltransferase, glycoprotein fucosyltransferase, guanosine diphosphofucose-glycoprotein fucosyltransferase, NodZ, NodZ fucosyltransferase

ECTree

     2 Transferases
         2.4 Glycosyltransferases
             2.4.1 Hexosyltransferases
                2.4.1.68 glycoprotein 6-alpha-L-fucosyltransferase

Inhibitors

Inhibitors on EC 2.4.1.68 - glycoprotein 6-alpha-L-fucosyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-mercaptoethanol
-
inactivation
Ca2+
-
-
dGDP
-
-
diethyl dicarbonate
-
10 mM, about 90% inhibition
diphosphate
-
-
EDTA
-
slight inhibition
GDP-glucose
-
-
GDP-mannose
-
-
gefitinib
-
-
iodoacetamide
-
10 mM, about 50% inhibition
iodoacetic acid
-
10 mM, 35% inhibition
Mersalyl
-
5 mM, complete inhibition, inhibition can be very significantly prevented by GDP-fucose, GDP or GnGnGp
methyl (1Z)-N-[[5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)pentyl]sulfanyl]-3-[(beta-L-fucopyranosyl)oxy]propanimidate
analogue of guanosine 5'-diphospho-beta-L-fucose. 57% inhibition at 0.1 microM
methyl iodide
-
1 mM, about 70% inhibition
Mg2+
-
slight inhibition
N-ethylmaleimide
PCMB
-
5 mM, complete inhibition, inhibition can be very significantly prevented by GDP-fucose, GDP or GnGnGp
Phenylglyoxal
-
10 mM, 90% inhibition
pyridoxal 5'-phosphate
-
10 mM, about 85% inhibition
streptavidin
-
inhibition due to stereochemical blockage of the fucosylation site
-
additional information
-