2.4.1.68: glycoprotein 6-alpha-L-fucosyltransferase
This is an abbreviated version!
For detailed information about glycoprotein 6-alpha-L-fucosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.68
Reaction
+
=
+
Synonyms
6FucT, alfC, alpha(1,6)FT, alpha(1,6)fucosyltransferase, alpha-1,6-fucosyltransferase, alpha-6-fucosyltransferase, alpha1,6-fucosyltransferase, alpha1,6-FucT, alpha1,6FucT, alpha1-6,fucosyltransferase, alpha1-6FucT, alpha6FucT, BN194_28780, fucosyltransferase 8, fucosyltransferase, guanosine diphosphofucose-glycoprotein, FUT8, GDP-fucose glycoprotein fucosyltransferase, GDP-fucose-glycoprotein fucosyltransferase, GDP-L-fuc:N-acetyl-beta-D-glucosaminide alpha1-6fucosyltransferase, GDP-L-fucose-glycoprotein fucosyltransferase, GDP-L-fucose:2-acetamido-2-deoxy-beta-D-glucoside 6-alpha-L-fucosyltransferase, GDPfucose glycoprotein fucosyltransferase, glycoprotein fucosyltransferase, guanosine diphosphofucose-glycoprotein fucosyltransferase, NodZ, NodZ fucosyltransferase
ECTree
Inhibitors
Inhibitors on EC 2.4.1.68 - glycoprotein 6-alpha-L-fucosyltransferase
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2-mercaptoethanol
-
inactivation
diethyl dicarbonate
-
10 mM, about 90% inhibition
iodoacetamide
-
10 mM, about 50% inhibition
iodoacetic acid
-
10 mM, 35% inhibition
Mersalyl
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5 mM, complete inhibition, inhibition can be very significantly prevented by GDP-fucose, GDP or GnGnGp
methyl (1Z)-N-[[5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)pentyl]sulfanyl]-3-[(beta-L-fucopyranosyl)oxy]propanimidate
analogue of guanosine 5'-diphospho-beta-L-fucose. 57% inhibition at 0.1 microM
methyl iodide
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1 mM, about 70% inhibition
PCMB
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5 mM, complete inhibition, inhibition can be very significantly prevented by GDP-fucose, GDP or GnGnGp
Phenylglyoxal
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10 mM, 90% inhibition
pyridoxal 5'-phosphate
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10 mM, about 85% inhibition
streptavidin
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inhibition due to stereochemical blockage of the fucosylation site
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Cd2+
-
Co2+
-
Cu2+
-
complete inhibition
Cu2+
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complete inhibition
Cu2+
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complete inhibition
GDP
-
-
GMP
-
-
Mn2+
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slight inhibition
N-ethylmaleimide
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slight inhibition
N-ethylmaleimide
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slight inhibition
N-ethylmaleimide
-
not affected by
N-ethylmaleimide
-
not affected by
Ni2+
-
-
Zn2+
-
strong inhibition
additional information
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no effect of Ca2+, Co2+
-
additional information
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no inhibition by EDTA, Mg2+, Ca2+
-
additional information
no inhibition by EDTA, Mg2+, Ca2+
-
additional information
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-
-
additional information
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-
additional information
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no effect of EDTA, Ni2+
-
additional information
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no effect of EDTA, Ba2+
-
additional information
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no inhibition by EDTA, Mg2+, Ca2+
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additional information
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no inhibition by EDTA, Mg2+, Ca2+
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additional information
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-
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additional information
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-
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additional information
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