2.4.1.66: procollagen glucosyltransferase
This is an abbreviated version!
For detailed information about procollagen glucosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.66
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2.4.1.66
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prolyl
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gg
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4-hydroxylase
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galactosyltransferase
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propeptide
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soleus
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aminoterminal
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hyp
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tibialis
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4-hydroxyproline
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chick-embryo
- 2.4.1.66
-
prolyl
- gg
-
4-hydroxylase
-
galactosyltransferase
- propeptide
- soleus
-
aminoterminal
- hyp
- tibialis
- 4-hydroxyproline
-
chick-embryo
Reaction
Synonyms
collagen glucosyltransferase, collagen hydroxylysyl glucosyltransferase, galactosylhydroxylysine glucosyltransferase, galactosylhydroxylysyl glucosyltransferase, GGT, glucosyltransferase, uridine diphosphoglucose-collagen, LH3, LH3/PLOD3, lysyl hydroxylase, lysyl hydroxylase 3, More, multifunctional procollagen lysine hydroxylase and glycosyltransferase, PLOD3, UDP-glucose-collagen glucosyltransferase, UDP-glucose:galactosylhydroxylysine-collagen glucosyltransferase, uridine diphosphoglucose-collagen glucosyltransferase
ECTree
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Source Tissue
Source Tissue on EC 2.4.1.66 - procollagen glucosyltransferase
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fetal lung WI-38 and IMR-90 diploid fibroblasts, in cell suspension culture
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fetal lung WI-38 and IMR-90 diploid fibroblasts, in cell suspension culture
additional information
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fetal lung WI-38 and IMR-90 diploid fibroblasts, in cell suspension culture
additional information
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the reduction of the galactosylhydroxylysyl glucosyltransferase activity of LH3 disrupts the localization of type IV collagen, and thus the formation of basement membranes during mouse embryogenesis leading to lethality at embryonic day 9.5-14.5. Survival of hypomorphic embryos and the formation of the basement membrane are directly correlated with the level of galactosylhydroxylysyl glucosyltransferase activity. An LH3-knockout mouse lacks galactosylhydroxylysyl glucosyltransferase. Lysyl hydroxylase 3 is the main molecule responsible for galactosylhydroxylysyl glucosyltransferase activity. Galactosylhydroxylysyl glucosyltransferase is essential for the formation of the basement membrane