2.4.1.66: procollagen glucosyltransferase
This is an abbreviated version!
For detailed information about procollagen glucosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.66
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2.4.1.66
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prolyl
-
gg
-
4-hydroxylase
-
galactosyltransferase
-
propeptide
-
soleus
-
aminoterminal
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hyp
-
tibialis
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4-hydroxyproline
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chick-embryo
- 2.4.1.66
-
prolyl
- gg
-
4-hydroxylase
-
galactosyltransferase
- propeptide
- soleus
-
aminoterminal
- hyp
- tibialis
- 4-hydroxyproline
-
chick-embryo
Reaction
Synonyms
collagen glucosyltransferase, collagen hydroxylysyl glucosyltransferase, galactosylhydroxylysine glucosyltransferase, galactosylhydroxylysyl glucosyltransferase, GGT, glucosyltransferase, uridine diphosphoglucose-collagen, LH3, LH3/PLOD3, lysyl hydroxylase, lysyl hydroxylase 3, More, multifunctional procollagen lysine hydroxylase and glycosyltransferase, PLOD3, UDP-glucose-collagen glucosyltransferase, UDP-glucose:galactosylhydroxylysine-collagen glucosyltransferase, uridine diphosphoglucose-collagen glucosyltransferase
ECTree
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Metals Ions
Metals Ions on EC 2.4.1.66 - procollagen glucosyltransferase
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Ca2+
Co2+
Fe2+
Mg2+
Mn2+
additional information
Ca2+
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Mn2+ is the most effective metal cofactor, partial replacement with Co2+, Mg2+ and Ca2+
Co2+
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activates at low but inhibits at high concentrations, optimal concentration: 0.3 mM, 80% as effective as 0.01 mM Mn2+
Co2+
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Mn2+ is the most effective metal cofactor, partial replacement with Co2+, Mg2+ and Ca2+, optimal concentration: 2.5 mM
Fe2+
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optimal concentration: 0.03 mM, activates at low but inhibits at high concentrations
Fe2+
contributes to the overall enzyme stabilization, enzymatic activity peaks at 25 microM Fe2+
Mg2+
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Mn2+ is the most effective metal cofactor, partial replacement with Co2+, Mg2+ and Ca2+, optimal concentration: 30 mM
Mn2+
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partial replacement of Mn2+ with Co2+, Mg2+ and Ca2+, enzyme-Mn2+ is required for the binding of the substrate and co-substrate
Mn2+
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25-80 mM: optimal concentration for free galactosylhydroxylysine as acceptor, 2 mM: optimal concentration for galactosylhydroxylysine bound in purified alpha1-chain of chicken skin collagen as acceptor, soluble enzyme is inhibited above 50 mM