2.4.1.66: procollagen glucosyltransferase
This is an abbreviated version!
For detailed information about procollagen glucosyltransferase, go to the full flat file.
Word Map on EC 2.4.1.66
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2.4.1.66
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prolyl
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gg
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4-hydroxylase
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galactosyltransferase
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propeptide
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soleus
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aminoterminal
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hyp
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tibialis
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4-hydroxyproline
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chick-embryo
- 2.4.1.66
-
prolyl
- gg
-
4-hydroxylase
-
galactosyltransferase
- propeptide
- soleus
-
aminoterminal
- hyp
- tibialis
- 4-hydroxyproline
-
chick-embryo
Reaction
Synonyms
collagen glucosyltransferase, collagen hydroxylysyl glucosyltransferase, galactosylhydroxylysine glucosyltransferase, galactosylhydroxylysyl glucosyltransferase, GGT, glucosyltransferase, uridine diphosphoglucose-collagen, LH3, LH3/PLOD3, lysyl hydroxylase, lysyl hydroxylase 3, More, multifunctional procollagen lysine hydroxylase and glycosyltransferase, PLOD3, UDP-glucose-collagen glucosyltransferase, UDP-glucose:galactosylhydroxylysine-collagen glucosyltransferase, uridine diphosphoglucose-collagen glucosyltransferase
ECTree
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Engineering
Engineering on EC 2.4.1.66 - procollagen glucosyltransferase
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D187A/D189A/D190A/D191A
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the mutant shows unreduced lysyl hydroxylase 3 activity
additional information
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mutagenesis of aspartates of the DXD-like motif in LH3 eliminates GGT activity
additional information
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mutation of aspartates in the positions 187-191 significantly reduces GGT activity of LH3
additional information
A195G/A434G/C882T/A1011G, reduced amount of LH3 in humans with epidermolysis bullosa simplex, only 30% GGT activity in cell lysate, only 40% GGT activity in the culture medium
additional information
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A668G, higher apparent molecular mass, reduced collagen galctosyltransferase, EC 2.4.1.50, and about 80% reduced glucosyltransferase activity, about 50% decreased lysyl hydroxylase activity, EC 1.14.11.4
additional information
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delT2071, lower apparent molecular mass, reduced collagen galctosyltransferase, EC 2.4.1.50, and about 50% reduced glucosyltransferase activity, complete loss of lysyl hydroxylase activity, EC 1.14.11.4
additional information
LH-deficient mutant, deficiency of LH3 glycosyltransferase activity decreases cell growth and increases lethality
additional information
overexpression of LH3, increased hydroxylation of lysyl residues and increased galactosylation and glucosylation of hydroxylysyl residues
additional information
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MEF+/-, lysyl hydroxylase 3 knock-out mice, only 80% GGT activity in cell lysate, only 5% GGT activity in the culture medium