2.4.1.65: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

This is an abbreviated version!
For detailed information about 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.65

2.4.1.65

fucosylation

sialylated

fucts

selectins

e-selectin

gdp-fucose

n-acetyllactosamine

sialyl-lewis

lewisa

synthesis

lacto-n-neotetraose

lacto-n-tetraose

fuct-iv

alpha1,3fucosyltransferase

molecular biology

Reaction

beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-R

beta-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->4)]-N-acetyl-beta-D-glucosaminyl-R

Synonyms

(Lea)-dependent alpha-3/4-fucosyltransferase, alpha 1,3-fucosyltransferase VII, alpha 1,3/4 fucosyltransferase, alpha(1,3) fucosyltransferase, alpha(1,3/1,4) fucosyltransferase III, alpha(1,3/4) fucosyltransferase, alpha(1,3/4)-FUT, alpha-(1,3/1,4)-fucosyltransferase, alpha-(1,3/1,4)-FucT, alpha-(1-3/4)-fucosyltransferase, alpha-(1->4)-L-fucosyltransferase, alpha-1,3 fucosyltransferase, alpha-1,3-fucosyltransferase, alpha-1,3/4-fucosyltransferase, alpha-1,3fucosyltransferase, alpha-1,4 fucosyltransferase, alpha-3-FUT, alpha-3/4 fucosyltransferase, alpha-3/4 fucosyltransferase III, alpha-3/4-FUT, alpha-4-fucosyltransferase, alpha-4-L-fucosyltransferase, alpha1,3 fucosyltransferase, alpha1,3 fucosyltransferase VII, alpha1,3-fucosyltransferase, alpha1,3-fucosyltransferase IX, alpha1,3-fucosyltransferase VI, alpha1,3/1,4FucT III, alpha1,3/4-fucosyltransferase, alpha1,3/4-fucosyltransferase VI, alpha1,3/4-fucosyltransferases-V and -VI, alpha1,3/4-FUT, alpha1,3FucT IV, alpha1,3FucT IX, alpha1,3FucT V, alpha1,3FucT VI, alpha1,3FucT VII, alpha3/4 fucosyltransferase 3, alpha3/4 fucosyltransferases, alpha3/4FucT, alpha4-fucosyltransferase, alpha4-FucT, alphaFucT, beta-acetylglucosaminylsaccharide fucosyltransferase, blood group Lewis alpha-4-fucosyltransferase, blood-group substance Lea-dependent fucosyltransferase, FT-IV, FT-VII, FT3, FT6, FT7, Fuc-T, Fuc-TIII, fucosyltransferase, fucosyltransferase 3, fucosyltransferase 5, fucosyltransferase 6, fucosyltransferase 7, fucosyltransferase IV, fucosyltransferase V, fucosyltransferase VI, fucosyltransferase VII, fucosyltransferase, guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-, fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-alpha-, FucT, FucT III, FucT IV, FucT IX, FucT V, FucT VI, FucT VII, FucT-II, FucT-III, FucT-V, FucT-VI, FucT-VII, FucTIII, FUT III, FUT10, FUT11, Fut13, FUT3, FUT4, FUT5, FUT6, FUT7, Fut9, GDP-Fuc: beta-D-Galp-(1-3/4)-beta-D-GlcpNAc-(1-4'/3')-alpha-fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase, Lewis alpha-3-fucosyltransferase, Lewis alpha-3/4-fucosyltransferase, Lewis alpha1-3/4 fucosyltransferase, Lewis blood group alpha1-3/4 fucosyltransferase, Lewis(Le) blood group gene-dependent alpha-3/4-L-fucosyltransferase, SFT3, sFUT5, sperm fucosyltransferase-5, UA948FucT

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.65 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

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Results	in table
2	Activating Compound
28	AA Sequence
5	Application
1	CAS Registry Number
27	Cloned(Commentary)
286	Disease/ Diagnostics
5	Expression
14	General Information
11	IC50 Value
62	Inhibitors
26	Ki Value [mM]
121	KM Value [mM]
33	Localization
30	Metals/Ions
16	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
87	Organism
6	Pathway
8	pH Optimum
2	pH Range
3	pI Value
3	Posttranslational Modification
45	Protein Variants
13	Purification (Commentary)
1	Reaction
17	Reaction Type
77	Reference
71	Source Tissue
27	Specific Activity [micromol/min/mg]
6	Storage Stability
237	Substrates and Products (Substrate)
15	Subunits
176	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
3	Temperature Range [°C]
3	Temperature Stability [°C]
15	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 2.4.1.65 - 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase

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9-(5'-O-[(alpha,beta-L-fucopyranosyl)oxycarbonylaminosulfonyl]-beta-D-ribofuranosyl)-guanine

Homo sapiens

691644

0.049

dGDP

Homo sapiens

at pH 4.5 and 37°C

735774

710

Galbeta(1,4)(3-deoxy)GlcNAcbetaOallyl

Homo sapiens

IC50: 710 mM

637634

Galbeta(1,4)deoxynojirimycin

Homo sapiens

IC50: 8 mM

637634

0.059

GDP

Homo sapiens

at pH 4.5 and 37°C

735774

0.104

GDP-6-amino-beta-L-fucose

Homo sapiens

at pH 4.5 and 37°C

735774

GDP-Man

Homo sapiens

IC50: 2 mM

637634

0.094

GTP

Homo sapiens

at pH 4.5 and 37°C

735774

0.134

[1-(beta-D-fucopyranosyl)-1H-1,2,3-triazole-4-yl]methylguanosine diphosphate

Homo sapiens

at pH 4.5 and 37°C

735774

0.247

[1-(beta-D-galactopyranosyl)-1H-1,2,3-triazole-4-yl] methylguanosine diphosphate

Homo sapiens

at pH 4.5 and 37°C

735774

0.139

[1-(beta-L-fucopyranosyl)-1H-1,2,3-triazole-4-yl]methylguanosine diphosphate

Homo sapiens

at pH 4.5 and 37°C

735774