2.4.1.62: ganglioside galactosyltransferase

This is an abbreviated version!
For detailed information about ganglioside galactosyltransferase, go to the full flat file.

Word Map on EC 2.4.1.62

2.4.1.62

myelin

galactocerebroside

galactosylceramide

sulfatide

cerebroside

galactolipids

cgalt

beta1,3-galactosyltransferase

udp-glucose:ceramide

galcer

myelin-specific

2.4.1.45

galt-4

biotechnology

Reaction

an N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[alpha-N-acetylneuraminyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Synonyms

B3GALT4, beta 1,3-galactosyltransferase, beta3Gal-T, ceramide galactosyltransferase, ceramide galactosyltransferase UGT8, CGT, CgtB 11168, cgtBOH HS:10, cgtBOH4384, GA1/GM1/GD1b synthase, Gal-T2, galactosyltransferase, uridine diphosphogalactose-ceramide, GALT, GalT-3, GM1-synthase, UDP galactose-LAC Tet-ceramide alpha-galactosyltransferase, UDP-galactose-ceramide galactosyltransferase, UDP-galactose-GM2 galactosyltransferase, UDP-galactose-GM2 ganglioside galactosyltransferase, UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase, UDP-galactose:ceramide galactosyltransferase, UDP-galactose:GM2 ganglioside beta1-3 galactosyltransferase, UDP-galactose:N-acetylgalactosaminyl-(N-acetylneuraminyl) galactosyl-glucosyl-ceramide galactosyltransferase, uridine diphosphate D-galactose:glycolipid galactosyltransferase, uridine diphosphogalactose-ceramide galactosyltransferase, uridine diphosphogalactose-GM2 galactosyltransferase

ECTree

2 Transferases

2.4 Glycosyltransferases

2.4.1 Hexosyltransferases

2.4.1.62 ganglioside galactosyltransferase

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Results	in table
9	Activating Compound
12	AA Sequence
1	Application
1	CAS Registry Number
11	Cloned(Commentary)
55	Disease/ Diagnostics
3	Expression
3	General Information
1	General Stability
20	Inhibitors
15	KM Value [mM]
27	Localization
18	Metals/Ions
11	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
364	Organism
3	Pathway
5	pH Optimum
15	Posttranslational Modification
11	Protein Variants
3	Purification (Commentary)
1	Reaction
1	Reaction Type
31	Reference
33	Source Tissue
12	Specific Activity [micromol/min/mg]
1	Storage Stability
49	Substrates and Products (Substrate)
7	Subunits
45	Synonyms
1	Systematic Name
3	Temperature Optimum [°C]
3	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 2.4.1.62 - ganglioside galactosyltransferase

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Brij 56

cardiolipin

EDTA

Endogenous membrane protein

Rattus norvegicus

heat-stable, protease sensitive, non-dialyzable, also found in other species

489309

Gangliosides and ganglioside components

Lithobates pipiens

most active: disialoganglioside

489306

GM2

2 entries

N-acetylneuraminic acid

Lithobates pipiens

with or without tetrahexosylceramide

489306

N-acetylneuraminyllactose

Lithobates pipiens

weak

489306

ovine-asialo-agalacto submaxillary mucin

Gallus gallus

489312

PP55B

Mus musculus

i.e. isopropylidene derivative of 5'-O-[[(2-decanoylamino-3-phenylpropylloxycarbonyl)amino]sulfonyl]uridine, 21% inhibition at 0.2 mM

SDS

Triton X-100

in excess, phospholipids protect

Tween 80

UDP-galactose

above 0.2 mM

additional information

Lithobates pipiens

no inhibition by fetuin, glucosylceramide, lactosylceramide or trihexosylceramide

489306